{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:52:08Z","timestamp":1791190328737,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009087","name":"Universidad Industrial de Santander","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009087","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Retos y Agendas de Investigaci\u00f3n UIS"},{"name":"Programa estrat\u00e9gico de investigaci\u00f3n aplicada interdisciplinar","award":["4259"],"award-info":[{"award-number":["4259"]}]},{"DOI":"10.13039\/501100000683","name":"Royal Society of Tropical Medicine and Hygiene","doi-asserted-by":"publisher","award":["978"],"award-info":[{"award-number":["978"]}],"id":[{"id":"10.13039\/501100000683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chagas disease (CD), caused by Trypanosoma cruzi, is a leading cause of cardiomyopathy in Latin America. Community-based prospective data on the CD\u2013mortality association remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed the ANTORCHA prospective cohort, enrolling individuals from T. cruzi-endemic communities in Santander, Colombia (2015\u20132025). The primary exposure was serologically confirmed CD; the primary outcome was all-cause mortality. Cox proportional hazards models with hierarchical adjustment and restricted mean survival time (RMST) were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1509 participants (314 Chagas positive), 81 deaths occurred over a median follow-up of 5.6 y. After full multivariate adjustment, CD was not associated with overall mortality (hazard ratio [HR] 1.02 [95% confidence interval {CI} 0.61 to 1.72]). A significant age-dependent interaction was identified (p=0.007): CD was independently associated with increased mortality among participants &amp;lt;60 y of age (HR 4.96 [95% CI 1.80 to 13.71]) but not among those \u226560 y of age (HR 0.73 [95% CI 0.43 to 1.22]). RMST analysis confirmed an absolute survival loss of 121 d at approximately 10 y of follow-up in the younger subgroup (p=0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this community-based cohort, CD was independently associated with markedly elevated mortality among adults &amp;lt;60\u00a0y of age. Younger T. cruzi-positive individuals warrant intensified cardiovascular surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag074","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:52:17Z","timestamp":1783687937000},"page":"1058-1067","source":"Crossref","is-referenced-by-count":0,"title":["Chagas disease and mortality in a community-based cohort in Colombia: evidence for age-dependent effect modification"],"prefix":"10.1093","volume":"120","author":[{"given":"Martha Luc\u00eda","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Grupo de Inmunolog\u00eda y Epidemiolog\u00eda Molecular, Universidad Industrial de Santander , Carrera 32 #29-31, 680002 Bucaramanga ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyda Z","family":"Rojas","sequence":"additional","affiliation":[{"name":"Research Center, Fundaci\u00f3n Cardiovascular de Colombia , Calle 155A No. 23-58 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