{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:51:48Z","timestamp":1791190308282,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010409","name":"Children's Investment Fund Foundation","doi-asserted-by":"publisher","award":["R-1805-02741"],"award-info":[{"award-number":["R-1805-02741"]}],"id":[{"id":"10.13039\/100010409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Predisposition to reinfection is characterized by certain individuals repeatedly acquiring infection at higher rates than others in the population despite treatment. As endemic regions approach low prevalence levels, such individuals will act as reservoirs of infection and contribute to sustaining transmission cycles in communities. This study investigated evidence for individual-level predisposition to Ascaris lumbricoides infections using longitudinal data from the Geshiyaro project in southern Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal parasitological data collected over 7 years were analysed. Kendall\u2019s tau (\u03c4) correlation coefficient was used to assess temporal persistence of infection between successive survey rounds, and Kendall\u2019s coefficient of concordance (W) was used to evaluate long-term stability in individuals\u2019 relative infection risk over many years of survey rounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Positive correlations in infection status between survey rounds were observed (\u03c4 = 0.10\u20130.30, P &amp;lt; .001). Moderate concordance in infection ranking across the study period was also detected (W = 0.43, 95% CI: 0.42\u20130.45; P &amp;lt; .001), indicating persistent individual-level predisposition over many years of treatment and reinfection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate sustained heterogeneity in infection risk within endemic communities. As transmission declines, identifying individuals predisposed to reinfection may help inform targeted or complementary \u2018test-and-treat\u2019 strategies to support interruption of A. lumbricoides transmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag075","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:00:11Z","timestamp":1783328411000},"page":"1068-1077","source":"Crossref","is-referenced-by-count":0,"title":["Predisposition to\n                    <i>Ascaris lumbricoides<\/i>\n                    reinfection in the Geshiyaro project in southern Ethiopia"],"prefix":"10.1093","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3508-3320","authenticated-orcid":false,"given":"Olivia","family":"Simmonds","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London , 90 Wood Lane, London W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-3103","authenticated-orcid":false,"given":"Rosie","family":"Maddren","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London , 90 Wood Lane, London W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Collyer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London , 90 Wood Lane, London W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birhan","family":"Abtew","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London , 90 Wood Lane, London W12 0BZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewnetu Firdawek","family":"Liyew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melkie","family":"Chernet","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew","family":"Tollera","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremew","family":"Tasew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esayas","family":"Knife","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahlet","family":"Belachew","sequence":"additional","affiliation":[{"name":"Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute , Swaziland Street, 2PWJ P8C, Addis Ababa 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