{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:20:35Z","timestamp":1788254435268,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the predictive value of admission platelet-related indices for in-hospital mortality in Crimean\u2013Congo haemorrhagic fever (CCHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-centre study included adults with laboratory-confirmed CCHF between May 2022 and May 2023. The primary outcome was in-hospital mortality. Admission laboratory parameters and platelet-related indices were analysed using receiver operating characteristics analysis, DeLong comparisons, 2000-replicate bootstrap internal validation and reduced Firth logistic regression adjusted for age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 167 patients (median age 47\u00a0y [interquartile range 34\u201362], 61.7% male) were included; 14 (8.4%) died. Non-survivors were older. Platelet count, platelet count multiplied by lymphocyte count (PLT\u00d7LYM) and plateletcrit were lower, whereas mean platelet volume:lymphocyte ratio, platelet distribution width:lymphocyte ratio and mean platelet volume:platelet count ratio were higher in non-survivors. Median PLT\u00d7LYM was lower in non-survivors than survivors (15.35 vs 49.56; p&amp;lt;0.001). PLT\u00d7LYM had the highest discriminatory performance (area under the curve 0.882, cut-off 39.33, sensitivity 100%, specificity 66.7%, positive predictive value 21.5%, negative predictive value 100.0%). In the logistic regression model, each 10-unit increase in PLT\u00d7LYM was associated with an adjusted odds ratio of 0.50 (95% confidence interval 0.30 to 0.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Admission PLT\u00d7LYM may serve as practical early marker for mortality risk stratification in CCHF; external validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag103","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:23:22Z","timestamp":1786361002000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of platelet indices as early markers of mortality in patients with Crimean\u2013Congo haemorrhagic fever: a retrospective observational study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-6288","authenticated-orcid":false,"given":"Rukiye","family":"\u0130nan\u00a0Sar\u0131kaya","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bal\u0131kesir University , \u00c7a\u011f\u0131\u015f Campus, Bigadi\u00e7 Road 17th km, 10145 Alt\u0131eyl\u00fcl, Bal\u0131kesir ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayten","family":"Yan\u0131k","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Erzurum City Hospital , \u00c7at Yolu Street No:2, 25240 Yakutiye, Erzurum ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Kara\u015fahin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical 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