{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:09:11Z","timestamp":1792786151746,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Secretar\u00eda de Ciencia, Arte y Tecnolog\u00eda"},{"DOI":"10.13039\/501100006284","name":"Universidad Nacional del Centro de la Provincia de Buenos Aires","doi-asserted-by":"publisher","award":["03-PIO-113H"],"award-info":[{"award-number":["03-PIO-113H"]}],"id":[{"id":"10.13039\/501100006284","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretar\u00eda de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","award":["CONVE-2023-100734805-APN-MCT"],"award-info":[{"award-number":["CONVE-2023-100734805-APN-MCT"]}],"id":[{"id":"https:\/\/ror.org\/03yw9pr65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Rural populations and pig production systems in Argentina may be at increased risk of HEV exposure; however, epidemiological data from these settings remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among residents of a rural community. Serum samples from 90 residents were tested for anti-HEV immunoglobulin G. Participants completed structured questionnaires and residential addresses were georeferenced to evaluate exposures and spatial distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rural residents reported greater exposure to homemade pork and wild boar sausages, wastewater, untreated well water, agricultural settings, livestock, rodents and flood-prone areas compared with levels previously documented in the urban population of the same region. The overall seroprevalence was 23.3% (95% confidence interval 14.0 to 32.6). Age and history of constipation were related with seropositivity. Rodent presence was more frequent in households of seropositive individuals, while feline contact coincided with reduced rodent occurrence. Spatial analysis identified one high-risk cluster (71.4% [5\/7], p&amp;gt;0.05) of seropositivity and one low-risk cluster (0% [0\/14], p&amp;gt;0.05), the latter corresponding to areas where contact with felines is greater.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HEV exposure may be substantial in this Argentine rural community, supporting the need for integrated One Health surveillance targeting sanitation, reservoirs and food safety. Larger studies are warranted to validate these findings and better define transmission pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/trstmh\/trag125","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:19:42Z","timestamp":1790335182000},"source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence and risk factors of hepatitis E virus infection in a rural Argentine community: a cross-sectional study"],"prefix":"10.1093","author":[{"given":"M A","family":"Rivero","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L P","family":"Arce","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de las Infecciones, Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO), CONICET\u2013Universidad Nacional de Tucum\u00e1n (UNT) , Tucum\u00e1n 4000 ,","place":["Argentina"]},{"name":"Instituto de Microbiolog\u00eda Dr. Luis C. Verna, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n (UNT) , Tucum\u00e1n 4000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tisn\u00e9s","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Humanas, Centro de Investigaciones Geogr\u00e1ficas (CIG), Instituto de Geograf\u00eda, Historia y Ciencias Sociales (IGEHCS), CONICET\u2013Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Silva","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Alegretti","sequence":"additional","affiliation":[{"name":"Hospital Enrique Rodr\u00edguez Larreta, Sistema Integrado de Salud P\u00fablica (SISP) , Municipio de Tandil, Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bar\u00f3n\u00a0Prato","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Humanas, Centro de Investigaciones Geogr\u00e1ficas (CIG), Instituto de Geograf\u00eda, Historia y Ciencias Sociales (IGEHCS), CONICET\u2013Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Estein","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN) , Buenos Aires, Tandil 7000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Vizoso\u00a0Pinto","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de las Infecciones, Instituto Superior de Investigaciones Biol\u00f3gicas (INSIBIO), CONICET\u2013Universidad Nacional de Tucum\u00e1n (UNT) , Tucum\u00e1n 4000 ,","place":["Argentina"]},{"name":"Instituto de Microbiolog\u00eda Dr. Luis C. Verna, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n (UNT) , Tucum\u00e1n 4000 ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101404583903700_bib1","volume-title":"One Health Joint Plan of Action (2022\u20132026): Working Together for the Health of Humans, Animals, Plants and the Environment","author":"Food and Agriculture Organization of the United Nations, United Nations Environment Programme, World Health Organization","year":"2022"},{"key":"2026101404583903700_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.sjbs.2021.09.003","article-title":"Hepatitis E virus: an emerging enigmatic and underestimated pathogen","volume":"29","author":"Raji","year":"2022","journal-title":"Saudi J Biol Sci"},{"key":"2026101404583903700_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s40506-020-00235-4","article-title":"A review of the diagnosis and management of hepatitis E","volume":"12","author":"Kar","year":"2020","journal-title":"Curr Treat Options Infect Dis"},{"key":"2026101404583903700_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3390\/healthcare9020133","article-title":"Towards the improved accuracy of hepatitis E diagnosis in vulnerable and target groups: a global perspective on the current state of knowledge and the implications for practice","volume":"9","author":"Talapko","year":"2021","journal-title":"Healthcare (Basel)"},{"key":"2026101404583903700_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mib.2020.07.004","article-title":"Hepatitis E virus: host tropism and zoonotic infection","volume":"59","author":"Wang","year":"2021","journal-title":"Curr Opin Microbiol"},{"key":"2026101404583903700_bib6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/pathogens14070704","article-title":"Hepatitis E virus (HEV) infection in the context of the One Health approach: a systematic review","volume":"14","author":"Tene","year":"2025","journal-title":"Pathogens"},{"key":"2026101404583903700_bib7","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/v15071558","article-title":"The re-emergence of hepatitis E virus in Europe and vaccine development","volume":"15","author":"Zahmanova","year":"2023","journal-title":"Viruses"},{"key":"2026101404583903700_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-981-99-1304-6_3","article-title":"Epidemiology of hepatitis E","volume-title":"Hepatitis E Virus. Advances in Experimental Medicine and Biology","author":"Geng","year":"2023"},{"key":"2026101404583903700_bib9","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1111\/liv.13881","article-title":"Hepatitis E virus in South America: the current scenario","volume":"38","author":"Pisano","year":"2018","journal-title":"Liver Int"},{"key":"2026101404583903700_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1708-8305.1997.tb00788.x","article-title":"Prevalence of IgG anti-HEV in Buenos Aires, a nonendemic area for hepatitis E","volume":"4","author":"Rey","year":"1997","journal-title":"J Travel Med"},{"key":"2026101404583903700_bib11","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.3389\/fmicb.2019.02481","article-title":"A novel in-house enzyme-linked immunosorbent assay for genotype 3 hepatitis E virus reveals high seroprevalence in blood donors in northern Argentina","volume":"10","author":"Arce","year":"2019","journal-title":"Front Microbiol"},{"key":"2026101404583903700_bib12","first-page":"314","article-title":"Serologic evidence of the circulation of the hepatitis E virus and the prevalence of antibodies against hepatitis A in an indigenous population in northern Argentina","volume":"53","author":"Remondegui","year":"2021","journal-title":"Rev Argent Microbiol"},{"key":"2026101404583903700_bib13","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/MEG.0000000000001853","article-title":"Seroprevalence of hepatitis E virus in Argentinean blood donors","volume":"33","author":"Di\u00a0Lello","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2026101404583903700_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/trstmh\/try048","article-title":"Environmental hepatitis E virus detection supported by serological evidence in the northwest of Argentina","volume":"112","author":"Pisano","year":"2018","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2026101404583903700_bib15","doi-asserted-by":"crossref","first-page":"105000","DOI":"10.1016\/j.rvsc.2023.105000","article-title":"High circulation of hepatitis E virus (HEV) in pigs from the central region of Argentina without evidence of virus occurrence in pork meat and derived products","volume":"164","author":"Di\u00a0Cola","year":"2023","journal-title":"Res Vet Sci"},{"key":"2026101404583903700_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3201\/eid3201.251218","article-title":"Evidence of rat hepatitis E virus circulation through wastewater surveillance, central Argentina","volume":"32","author":"Filoni","year":"2026","journal-title":"Emerg Infect Dis"},{"key":"2026101404583903700_bib17","doi-asserted-by":"crossref","first-page":"1257754","DOI":"10.3389\/fpubh.2023.1257754","article-title":"Exploring hepatitis E virus seroprevalence and associated risk factors among the human population in Tandil, Buenos Aires, Argentina","volume":"11","author":"Rivero","year":"2023","journal-title":"Front Public Health"},{"key":"2026101404583903700_bib18","doi-asserted-by":"crossref","first-page":"102082","DOI":"10.1016\/j.cimid.2023.102082","article-title":"Unraveling swine hepatitis E in the central region of Argentina through ELISA development and epidemiological insights","volume":"103","author":"Guti\u00e9rrez","year":"2023","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"2026101404583903700_bib19","first-page":"46","article-title":"Is the hepatitis E virus a silent zoonotic threat in backyard pig farms of Tandil county?","volume-title":"II Jornadas Integradas en Investigaci\u00f3n y Salud","author":"Guti\u00e9rrez","year":"2024"},{"key":"2026101404583903700_bib20","volume-title":"Censo Nacional de Poblaci\u00f3n, Hogares y Viviendas 2022: Resultados definitivos","author":"Instituto Nacional de Estad\u00edsticas y Censos","year":"2024"},{"key":"2026101404583903700_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.prevetmed.2015.05.012","article-title":"Spatial and temporal epidemiological analysis in the Big Data era","volume":"122","author":"Pfeiffer","year":"2015","journal-title":"Prev Vet Med"},{"key":"2026101404583903700_bib22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1128\/CMR.00057-13","article-title":"Hepatitis E virus infection","volume":"27","author":"Kamar","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2026101404583903700_bib23","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/microorganisms11071849","article-title":"The role of gut dysbiosis in the loss of intestinal immune cell functions and viral pathogenesis","volume":"11","author":"Fakharian","year":"2023","journal-title":"Microorganisms"},{"key":"2026101404583903700_bib24","doi-asserted-by":"crossref","first-page":"1098386","DOI":"10.3389\/fmicb.2023.1098386","article-title":"Role of gut microbiota in infectious and inflammatory diseases","volume":"14","author":"Maciel-Fiuza","year":"2023","journal-title":"Front Microbiol"},{"key":"2026101404583903700_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1890\/1540-9295(2004)002[0013:APGFYH]2.0.CO;2","article-title":"Are predators good for your health? Evaluating evidence for top-down regulation of zoonotic disease reservoirs","volume":"2","author":"Ostfeld","year":"2004","journal-title":"Front Ecol Environ"},{"key":"2026101404583903700_bib26","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s11259-024-10293-4","article-title":"Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal","volume":"48","author":"Santos-Silva","year":"2024","journal-title":"Vet Res Commun"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/trstmh\/advance-article-pdf\/doi\/10.1093\/trstmh\/trag125\/71929142\/trag125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/trstmh\/advance-article-pdf\/doi\/10.1093\/trstmh\/trag125\/71929142\/trag125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:58:46Z","timestamp":1791968326000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/advance-article\/doi\/10.1093\/trstmh\/trag125\/8915875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trag125","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"trag125"}}