{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:14:20Z","timestamp":1775646860524,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/trstmh\/trx066","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T15:28:46Z","timestamp":1508858926000},"page":"336-344","source":"Crossref","is-referenced-by-count":33,"title":["Drug treatment of scrub typhus: a systematic review and meta-analysis of controlled clinical trials"],"prefix":"10.1093","volume":"111","author":[{"given":"Ian","family":"Wee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaturaka","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"issue":"6","key":"key\n\t\t\t\t20171222094531_trx066C1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.7883\/yoken.67.458","article-title":"Epidemiology of scrub typhus and the eschars patterns in South Korea from 2008 to 2012","volume":"67","year":"2014","journal-title":"Jpn J Infect Dis"},{"issue":"1","key":"key\n\t\t\t\t20171222094531_trx066C2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1286-4579(00)01352-6","article-title":"Orientia tsutsugamushi infection: overview and immune responses","volume":"3","year":"2001","journal-title":"Microbes Infect"},{"issue":"7","key":"key\n\t\t\t\t20171222094531_trx066C3","doi-asserted-by":"crossref","first-page":"e101976","DOI":"10.1371\/journal.pone.0101976","article-title":"Rapid increase of scrub typhus: an epidemiology and spatial-temporal cluster analysis in Guangzhou City, Southern China, 2006\u20132012","volume":"9","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"key\n\t\t\t\t20171222094531_trx066C4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/trstmh\/trx022","article-title":"The genotypes of Orientia tsutsugamushi, identified in scrub typhus patients in northern Vietnam","volume":"111","year":"2017","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6","key":"key\n\t\t\t\t20171222094531_trx066C5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12098-014-1664-4","article-title":"Scrub typhus: audit of an outbreak","volume":"82","year":"2015","journal-title":"Indian J Pediatr"},{"issue":"1","key":"key\n\t\t\t\t20171222094531_trx066C6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3201\/eid2101.140580","article-title":"Molecular epidemiology and genetic diversity of Orientia tsutsugamushi from patients with scrub typhus in 3 regions of India","volume":"21","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20171222094531_trx066C7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1186\/1756-0500-7-719","article-title":"Emerging scrub typhus infection in the northern region of Sri Lanka","volume":"7","year":"2014","journal-title":"BMC Res Notes"},{"issue":"2","key":"key\n\t\t\t\t20171222094531_trx066C8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/2224-3151.206248","article-title":"Scrub typhus in Bhutan: a synthesis of data from 2009 to 2014","volume":"5","year":"2016","journal-title":"WHO South East Asia J Public Health"},{"key":"key\n\t\t\t\t20171222094531_trx066C9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.actatropica.2014.10.012","article-title":"Distribution of rickettsioses in Oceania: past patterns and implications for the future","volume":"143","year":"2015","journal-title":"Acta Trop"},{"issue":"10","key":"key\n\t\t\t\t20171222094531_trx066C10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1348-0421.1999.tb03358.x","article-title":"Decreased prevalence of Orientia tsutsugamushi in trombiculid mites and wild rodents in the Primorye region, Far East Russia","volume":"43","year":"1999","journal-title":"Microbiol Immunol"},{"issue":"10","key":"key\n\t\t\t\t20171222094531_trx066C11","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMoa1603657","article-title":"Endemic scrub typhus in South America","volume":"375","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"key\n\t\t\t\t20171222094531_trx066C12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00001432-200310000-00009","article-title":"Scrub typhus and tropical rickettsioses","volume":"16","year":"2003","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"key\n\t\t\t\t20171222094531_trx066C13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12879-016-2153-3","article-title":"Rapid increase of scrub typhus incidence in Guangzhou, southern China, 2006\u20132014","volume":"17","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"8","key":"key\n\t\t\t\t20171222094531_trx066C14","doi-asserted-by":"crossref","first-page":"e0003971","DOI":"10.1371\/journal.pntd.0003971","article-title":"A systematic review of mortality from untreated scrub typhus (Orientia tsutsugamushi)","volume":"9","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"9020","key":"key\n\t\t\t\t20171222094531_trx066C15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(96)02501-9","article-title":"Scrub typhus infections poorly responsive to antibiotics in northern Thailand","volume":"348","year":"1996","journal-title":"Lancet"},{"issue":"17","key":"key\n\t\t\t\t20171222094531_trx066C16","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2169\/internalmedicine.51.7816","article-title":"Meta-analysis of drug treatment for scrub typhus in Asia","volume":"51","year":"2012","journal-title":"Intern Med"},{"issue":"3","key":"key\n\t\t\t\t20171222094531_trx066C17","first-page":"CD002150","article-title":"Antibiotics for treating scrub typhus","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"key\n\t\t\t\t20171222094531_trx066C18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/td.2010.100311","article-title":"Drug treatment of scrub typhus","volume":"41","year":"2011","journal-title":"Trop Doct"},{"key":"key\n\t\t\t\t20171222094531_trx066C19","volume-title":"Cochrane handbook for systematic reviews of interventions","year":"2008"},{"issue":"5","key":"key\n\t\t\t\t20171222094531_trx066C20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","year":"2010","journal-title":"Int J Surg"},{"key":"key\n\t\t\t\t20171222094531_trx066C21","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","year":"2011","journal-title":"BMJ"},{"issue":"3","key":"key\n\t\t\t\t20171222094531_trx066C22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/oxfordjournals.aje.a117250","article-title":"Quality scores are useless and potentially misleading: Reply to \u2018Re: A critical look at some popular analytic methods\u2019","volume":"140","year":"1994","journal-title":"Am J Epidemiol"},{"issue":"7414","key":"key\n\t\t\t\t20171222094531_trx066C23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","year":"2003","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20171222094531_trx066C24","first-page":"783","article-title":"Treatment of scrub typhus with macrolide antibiotic [in Chinese]","volume":"7","year":"2007","journal-title":"J Trop Med"},{"key":"key\n\t\t\t\t20171222094531_trx066C25","first-page":"59","article-title":"Effect of antibiotics in the treatment of scrub typhus in South China Sea area [in Chinese]","volume":"26","year":"2008","journal-title":"J Pre Med Chin PLA"},{"key":"key\n\t\t\t\t20171222094531_trx066C26","first-page":"163","article-title":"The third generation of quinolones therapy for scrub typhus [in Chinese]","volume":"2","year":"2002","journal-title":"J Trop Med"},{"issue":"4","key":"key\n\t\t\t\t20171222094531_trx066C27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0035-9203(78)90138-4","article-title":"Single dose doxycycline therapy for scrub typhus","volume":"72","year":"1978","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t20171222094531_trx066C28","first-page":"1936","article-title":"Effect of antibiotics in the treatment of scrub typhus [in Chinese]","volume":"23","year":"2007","journal-title":"Mod Med Health"},{"key":"key\n\t\t\t\t20171222094531_trx066C29","first-page":"66","article-title":"A comparison of azithromycin versus chloramphenicol for treatment of paediatric scrub typhus [in Chinese]","volume":"19","year":"2004","journal-title":"J Appl Clin Pediatr"},{"key":"key\n\t\t\t\t20171222094531_trx066C30","first-page":"32","article-title":"Effect of roxithromycin in the treatment of scrub typhus [in Chinese]","volume":"11","year":"2005","journal-title":"J Pediatr Pharm"},{"issue":"8","key":"key\n\t\t\t\t20171222094531_trx066C31","first-page":"756","article-title":"Randomized controlled trial of azithromycin versus doxycycline or chloramphenicol for treatment of uncomplicated pediatric scrub typhus","volume":"98","year":"2015","journal-title":"J Med Assoc Thai"},{"issue":"6","key":"key\n\t\t\t\t20171222094531_trx066C32","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/AAC.01460-06","article-title":"Controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus","volume":"51","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"key\n\t\t\t\t20171222094531_trx066C33","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1086\/425008","article-title":"A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus","volume":"39","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"9","key":"key\n\t\t\t\t20171222094531_trx066C34","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1128\/AAC.00508-07","article-title":"Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus","volume":"51","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"9235","key":"key\n\t\t\t\t20171222094531_trx066C35","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(00)02728-8","article-title":"Doxycycline and rifampicin for mild scrub-typhus infections in northern Thailand: a randomised trial","volume":"356","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"key\n\t\t\t\t20171222094531_trx066C36","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/clinids\/21.3.506","article-title":"Short-course doxycycline treatment versus conventional tetracycline therapy for scrub typhus: a multicenter randomized trial","volume":"21","year":"1995","journal-title":"Clin Infect Dis"},{"issue":"1","key":"key\n\t\t\t\t20171222094531_trx066C37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/archinte.1973.03650070069010","article-title":"Scrub typhus. A comparison of chloramphenicol and tetracycline in its treatment","volume":"132","year":"1973","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t20171222094531_trx066C38","first-page":"354","article-title":"Scrub typhus. A comparison of doxycycline and chloramphenicol in its treatment [in Chinese]","volume":"14","year":"1996","journal-title":"J Guangdong Med Coll"},{"key":"key\n\t\t\t\t20171222094531_trx066C39","first-page":"526","article-title":"Treatment of scrub typhus with several antibiotics [in Chinese]","volume":"25","year":"2009","journal-title":"J Pract Med"},{"key":"key\n\t\t\t\t20171222094531_trx066C40","first-page":"36","article-title":"Macrolide antibiotic to cure child scrub typhus [in Chinese]","volume":"10","year":"2004","journal-title":"J Pediatr Pharm"},{"issue":"4","key":"key\n\t\t\t\t20171222094531_trx066C41","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ijantimicag.2009.11.019","article-title":"Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi","volume":"35","year":"2010","journal-title":"Int J Antimicrob Agents"},{"issue":"5","key":"key\n\t\t\t\t20171222094531_trx066C42","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3346\/jkms.2013.28.5.667","article-title":"Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain","volume":"28","year":"2013","journal-title":"J Korean Med Sci"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/111\/8\/336\/23035616\/trx066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:50:20Z","timestamp":1513961420000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/trstmh\/article\/111\/8\/336\/4746672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,12,15]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trx066","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,8,1]]}}}