{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:58:59Z","timestamp":1790690339603,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/trstmh\/trz002","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T12:09:41Z","timestamp":1547294981000},"page":"163-168","source":"Crossref","is-referenced-by-count":12,"title":["The rise and fall of long-latency <i>Plasmodium vivax<\/i>"],"prefix":"10.1093","volume":"113","author":[{"given":"N J","family":"White","sequence":"first","affiliation":[{"name":"Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"issue":"1\u20132","key":"key\n\t\t\t\t2019032508395671700_trz002C1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0035-9203(24)90664-X","article-title":"Observations on malaria made during the treatment of general paralysis","volume":"18","author":"Yorke","year":"1924","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C2","first-page":"1105","article-title":"Die Behandlung der progressiven Paralyse und Tabes","volume":"71","author":"Wagner-Jauregg","year":"1921","journal-title":"Wien Med Wochenschr"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-407826-0.00006-0","article-title":"Malariotherapy\u2014insanity at the service of malariology","volume":"81","author":"Snounou","year":"2013","journal-title":"Adv Parasitol"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0035-9203(26)80002-1","article-title":"Further observations on malaria made during the treatment of general paralysis","volume":"19","author":"Yorke","year":"1926","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C5","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/bmj.2.2074.949","article-title":"Experimental proof of the mosquito-malaria theory","volume":"2","author":"Manson","year":"1900","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/bmj.2.2115.77","article-title":"Experimental malaria: recurrence after nine months","volume":"2","author":"Manson","year":"1901","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C7","volume-title":"Hereinneringsbundel voor Prof SS Rosenstein","author":"Korteweg","year":"1902"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C8","volume-title":"Malaria in the Netherlands","author":"Swellengrebel","year":"1938"},{"issue":"4","key":"key\n\t\t\t\t2019032508395671700_trz002C9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4269\/ajtmh.1944.s1-24.221","article-title":"Renewed clinical activity in vivax malaria","volume":"24","author":"Boyd","year":"1944","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"key\n\t\t\t\t2019032508395671700_trz002C10","first-page":"141","article-title":"Studies in human malaria. V. homologous strain superinfection during latency in subjects with sporozoite-induced vivax malaria (St. Elizabeth strain)","volume":"46","author":"Cooper","year":"1947","journal-title":"Am J Hyg"},{"issue":"2","key":"key\n\t\t\t\t2019032508395671700_trz002C11","first-page":"200","article-title":"Studies in human malaria. XVIII. The life pattern of sporozoite-induced St. Elizabeth strain vivax malaria","volume":"51","author":"Coatney","year":"1950","journal-title":"Am J Hyg"},{"issue":"2","key":"key\n\t\t\t\t2019032508395671700_trz002C12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/096777209400200207","article-title":"The Horton Malaria Laboratory, Epsom, Surrey (1925\u20131975)","volume":"2","author":"Rollin","year":"1994","journal-title":"J Med Biogr"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C13","first-page":"187","article-title":"Swellengrebel lecture. Hypnozoites and \u2018relapses\u2019 in Plasmodium vivax and in vivax-like malaria","volume":"40","author":"Garnham","year":"1988","journal-title":"Trop Geogr Med"},{"issue":"5","key":"key\n\t\t\t\t2019032508395671700_trz002C14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0035-9203(31)90068-0","article-title":"Some general results of a study of induced malaria in England","volume":"24","author":"James","year":"1931","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"8","key":"key\n\t\t\t\t2019032508395671700_trz002C15","first-page":"27","article-title":"Clinical and parasitological observations on induced malaria","volume":"29","author":"James","year":"1936","journal-title":"Proc R Soc Med"},{"issue":"11","key":"key\n\t\t\t\t2019032508395671700_trz002C16","first-page":"603","article-title":"A suggested standard treatment of malaria based on the results of controlled investigation of over 3700 cases","volume":"65","author":"Sinton","year":"1930","journal-title":"Indian Med Gaz"},{"issue":"1","key":"key\n\t\t\t\t2019032508395671700_trz002C17","first-page":"159","article-title":"Studies in malaria with special reference to treatment; plasmoquine in treatment of malaria","volume":"16","author":"Sinton","year":"1928","journal-title":"Indian J Med Res"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C18","first-page":"793","article-title":"Studies in malaria, with special reference to treatment. XII. Further researches into treatment of chronic benign tertian malaria with plasmoquine and quinine","volume":"17","author":"Sinton","year":"1930","journal-title":"Indian J Med Res"},{"issue":"4","key":"key\n\t\t\t\t2019032508395671700_trz002C19","first-page":"643","article-title":"A discussion of some points contained in the \u2018Third general report of the malaria commission on the therapeutics of malaria\u2019","volume":"4","author":"Sinton","year":"1935","journal-title":"Q Bull Health Org League Nations"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C20","first-page":"181","article-title":"The therapeutics of malaria: third general report of the Malaria Commission","volume":"2","author":"Malaria Commission","year":"1933","journal-title":"Q Bull Health Org League Nations"},{"issue":"4","key":"key\n\t\t\t\t2019032508395671700_trz002C21","first-page":"307","article-title":"The pharmacological basis for the rational use of atabrine in the treatment of malaria","volume":"81","author":"Shannon","year":"1944","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"key\n\t\t\t\t2019032508395671700_trz002C22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.7326\/0003-4819-25-1-103","article-title":"Plasmochin toxicity: analysis of 258 cases","volume":"25","author":"Hardgrove","year":"1946","journal-title":"Ann Intern Med"},{"issue":"5","key":"key\n\t\t\t\t2019032508395671700_trz002C23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0035-9203(45)90038-1","article-title":"Chemotherapeutic suppression and prophylaxis in malaria. An experimental investigation undertaken by medical research teams in Australia","volume":"38","author":"Fairley","year":"1945","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/infdis\/80.3.237","article-title":"The Chesson strain of Plasmodium vivax malaria; clinical aspects","volume":"80","author":"Whorton","year":"1947","journal-title":"J Infect Dis"},{"issue":"6","key":"key\n\t\t\t\t2019032508395671700_trz002C25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4269\/ajtmh.1986.35.1077","article-title":"Compatibility of relapse patterns of Plasmodium cynomolgi infections in rhesus monkeys with continuous cyclical development and hypnozoite concepts of relapse","volume":"35","author":"Schmidt","year":"1986","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"key\n\t\t\t\t2019032508395671700_trz002C26","first-page":"381","article-title":"Studies in human malaria. XXX. A summary of 204 sporozoite-induced infections with the Chesson strain of Plasmodium vivax","volume":"9","author":"Coatney","year":"1950","journal-title":"J Natl Malar Soc"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C27","first-page":"292","article-title":"Long latency in Plasmodium vivax infections in a temperate zone","volume":"7","author":"Winckel","year":"1955","journal-title":"Doc Med Geogr Trop"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C28","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/infdis\/80.3.228","article-title":"The Chesson strain of Plasmodium vivax malaria. I. Relationship between prepatent period, latent period and relapse rate","volume":"80","author":"Craige","year":"1947","journal-title":"J Infect Dis"},{"issue":"4","key":"key\n\t\t\t\t2019032508395671700_trz002C29","first-page":"285","article-title":"Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report","volume":"9","author":"Edgcomb","year":"1950","journal-title":"J Natl Malar Soc"},{"issue":"6","key":"key\n\t\t\t\t2019032508395671700_trz002C30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4269\/ajtmh.1953.2.958","article-title":"Korean vivax malaria. I. Natural history and response to chloroquine","volume":"2","author":"Hankey","year":"1953","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"key\n\t\t\t\t2019032508395671700_trz002C31","first-page":"723","article-title":"Natural history of Korean vivax malaria after deliberate inoculation of human volunteers","volume":"44","author":"Arnold","year":"1954","journal-title":"J Lab Clin Med"},{"issue":"6","key":"key\n\t\t\t\t2019032508395671700_trz002C32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4269\/ajtmh.1953.2.985","article-title":"Korean vivax malaria. V. Cure of the infection by primaquine administered during long-term latency","volume":"2","author":"Coatney","year":"1953","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"key\n\t\t\t\t2019032508395671700_trz002C33","doi-asserted-by":"crossref","first-page":"983","DOI":"10.4269\/ajtmh.1953.2.983","article-title":"Korean vivax malaria. IV. Curative effect of 15 milligrams of primaquine daily for 7 days","volume":"2","author":"Di Lorenzo","year":"1953","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C34","first-page":"201","article-title":"Subspecies of the parasite of tertian malaria (Plasmodium vivax)","volume":"67","author":"Nikolaiev","year":"1949","journal-title":"Dokl Akad Navk USSR"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C35","first-page":"446","article-title":"Features specific to the Moscow strain of P. vivax","volume":"30(4)","author":"Tiburskaya","year":"1961","journal-title":"Med Parazitol (Mosk)"},{"issue":"3","key":"key\n\t\t\t\t2019032508395671700_trz002C36","first-page":"447","article-title":"Dates of onset of relapses and the duration of infection in induced tertian malaria with short and long incubation periods","volume":"38","author":"Tiburskaja","year":"1968","journal-title":"Bull World Health Org"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C37","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12936-018-2495-y","article-title":"On the epidemiology of Plasmodium vivax malaria: past and present with special reference to the former USSR","volume":"17","author":"Kondrashin","year":"2018","journal-title":"Malar J"},{"issue":"1","key":"key\n\t\t\t\t2019032508395671700_trz002C38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4269\/ajtmh.1998.59.175","article-title":"Studies on the Plasmodium vivax relapse pattern in Delhi, India","volume":"59","author":"Adak","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C39","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/1475-2875-10-297","article-title":"Determinants of relapse periodicity in Plasmodium vivax malaria","volume":"10","author":"White","year":"2011","journal-title":"Malar J"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2875-13-144","article-title":"Geographical variation in Plasmodium vivax relapse","volume":"13","author":"Battle","year":"2012","journal-title":"Malar J"},{"issue":"7","key":"key\n\t\t\t\t2019032508395671700_trz002C41","doi-asserted-by":"crossref","first-page":"e39645","DOI":"10.1371\/journal.pone.0039645","article-title":"Genotyping of Plasmodium vivax reveals both short and long latency relapse patterns in Kolkata","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019032508395671700_trz002C42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/bmj.1.4550.547","article-title":"The pre-erythrocytic stage of human malaria, Plasmodium vivax","volume":"1","author":"Shortt","year":"1948","journal-title":"Br Med J"},{"issue":"7214","key":"key\n\t\t\t\t2019032508395671700_trz002C43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature07327","article-title":"Comparative genomics of the neglected human malaria parasite Plasmodium vivax","volume":"455","author":"Carlton","year":"2008","journal-title":"Nature"},{"issue":"5","key":"key\n\t\t\t\t2019032508395671700_trz002C44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4269\/ajtmh.1972.21.707","article-title":"Studies on the characterization of Plasmodium vivax strains from Central America","volume":"21","author":"Contacos","year":"1972","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"key\n\t\t\t\t2019032508395671700_trz002C45","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4269\/ajtmh.1982.31.1291","article-title":"Demonstration of hypnozoites in sporozoite-transmitted Plasmodium vivax infection","volume":"31","author":"Krotoski","year":"1982","journal-title":"Am J Trop Med Hyg"},{"issue":"9","key":"key\n\t\t\t\t2019032508395671700_trz002C46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1473-3099(09)70177-X","article-title":"Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite","volume":"9","author":"Mueller","year":"2009","journal-title":"Lancet Infect Dis"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/article-pdf\/113\/4\/163\/28215862\/trz002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T12:43:11Z","timestamp":1553517791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/article\/113\/4\/163\/5365537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,2,27]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trz002","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,2,27]]}}}