{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:07:43Z","timestamp":1789970863539,"version":"4.0.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malaria and human immunodeficiency virus (HIV) infections in pregnancy are important and major contributing factors to maternal morbidity and mortality in sub-Saharan Africa. Prevention of malaria in HIV-positive pregnant woman will reduce the burden of malaria\u2013HIV comorbidity. The objective of this study was to compare effects and safety of azithromycin (AZ) with sulphadoxine\u2013pyrimethamine (SP) for intermittent preventive therapy for malaria in HIV-positive pregnant women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a randomized, controlled, open-label pregnancy trial of 140 HIV-positive pregnant patients attending antenatal clinics at the University College Hospital and Adeoyo Maternity Teaching Hospital, Ibadan, Nigeria. Participants were enrolled from a gestational age of 16 weeks and randomized to receive AZ or SP. The primary outcome was peripheral parasitaemia at delivery. Secondary outcomes were drug tolerability, foetal outcome and birthweight. The \u03c72 test (or Fisher\u2019s exact test, as appropriate) and Student\u2019s t test were used in the per-protocol analysis. The level of statistical significance was p&lt;0.05.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 123 participants (87.9%) completed the study: 60 participants received AZ and 63 received SP. The incidence of malaria parasitaemia at delivery in the AZ group was 6 (10.0%), compared with 7 (11.1%) in the SP group (relative risk 0.89 [95% confidence interval 0.28 to 2.82], p=0.84). Placental parasitization was demonstrated in 1 (1.6%) participant in the SP group compared with 3 (5.0%) in the AZ group (p=0.36).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The findings suggest that AZ is comparable to SP in malaria prevention and safety in HIV-positive pregnant women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trz028","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T11:08:24Z","timestamp":1555931304000},"page":"463-470","source":"Crossref","is-referenced-by-count":13,"title":["A randomized controlled trial of azithromycin and sulphadoxine\u2013pyrimethamine as prophylaxis against malaria in pregnancy among human immunodeficiency virus\u2013positive women"],"prefix":"10.1093","volume":"113","author":[{"given":"Oriyomi","family":"Akinyotu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folasade","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukiyat","family":"Abdus-Salam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"},{"name":"Adeoyo Maternity Teaching Hospital, Yemetu, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodele","family":"Arowojolu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"issue":"1","key":"2019072701401618800_trz028C1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1475-2875-10-206","article-title":"Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical Africa","volume":"10","author":"Rizzo","year":"2011","journal-title":"Malar J"},{"issue":"2","key":"2019072701401618800_trz028C2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1086\/524889","article-title":"Plasmodium knowlesi: the fifth human malaria parasite","volume":"46","author":"White","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2019072701401618800_trz028C3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2019072701401618800_trz028C4","author":"World Health Organization"},{"key":"2019072701401618800_trz028C5","author":"World Health Organization"},{"issue":"12","key":"2019072701401618800_trz028C6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/JAMMR\/2018\/39620","article-title":"Prevalence of malaria in pregnant women attending antenatal clinic in primary health centres in Lagos. 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