{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:50:31Z","timestamp":1740138631381,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","award":["R025"],"award-info":[{"award-number":["R025"]}],"id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Namibia has made significant gains in the fight against malaria, with a target of elimination by 2023. We examined the genotype and allele frequencies of glucose-6-phosphate dehydrogenase (G6PD) deficiency to inform decisions on primaquine use, as we recently detected clusters of Plasmodium ovale curtisi in Kavango.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multistaged cross-sectional sampling method was used to enrol 212 children 2\u20139 y of age from schools and clinics in the Okavango and Zambezi regions of northern Namibia. Genotypes for the 202 G\u2192A and 376 A\u2192G mutations were assigned by polymerase chain reaction restriction fragment length polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 212 subjects enrolled, genotypes were available for 210, made up of 61 males and 149 females. G6PD-deficient males (hemizygotes) and females (homozygotes) constituted 3.27% (2\/61) and 0.0% (0\/149), respectively. Female heterozygotes (AA\u2212 and BA\u2212) constituted 10.07% (15\/149), while G6PD wild-type males (with A or B haplotype) and females (with AA, BB or AB haplotypes) consisted of 96.72% (59\/61) and 89.93% (134\/149), respectively. The A\u2212, A and B allele frequencies were 0.0474, 0.3036 and 0.6490, respectively. Hardy\u2013Weinberg equilibrium tests for female genotype frequencies did not show deviation (p=0.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The frequency of G6PD deficiency alleles in males in the Kavango and Zambezi regions of northern Namibia constitute 3.27%, a first report to inform policy on primaquine role out.<\/jats:p><\/jats:sec>","DOI":"10.1093\/trstmh\/trz035","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T15:51:58Z","timestamp":1554825118000},"page":"483-488","source":"Crossref","is-referenced-by-count":0,"title":["Glucose-6-phosphate dehydrogenase deficiency genotypes and allele frequencies in the Kavango and Zambezi regions of northern Namibia"],"prefix":"10.1093","volume":"113","author":[{"given":"Daniel H","family":"Haiyambo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Namibia School of Medicine, Windhoek, Namibia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Ilunga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Namibia School of Medicine, Windhoek, Namibia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Nangombe","sequence":"additional","affiliation":[{"name":"School of Nursing, Welwitchia University, Nkurenkuru, Namibia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Ababio","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toini","family":"Hatuikulipi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Namibia School of Medicine, Windhoek, 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