{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:14:34Z","timestamp":1778786074088,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01-NS39403"],"award-info":[{"award-number":["R01-NS39403"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-NS39403"],"award-info":[{"award-number":["R01-NS39403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Service Award","award":["5F31NS051946"],"award-info":[{"award-number":["5F31NS051946"]}]},{"DOI":"10.13039\/100006462","name":"City University of New York","doi-asserted-by":"publisher","award":["PSC-CUNY ENHC 47"],"award-info":[{"award-number":["PSC-CUNY ENHC 47"]}],"id":[{"id":"10.13039\/100006462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In neurocysticercosis, the larval form of the pork tapeworm Taenia solium appears to evolve through three phases\u2014active, degenerative and sometimes calcification\u2014before disappearance. The antihelmintic drug, albendazole, has been shown to hasten the resolution of active cysts in neurocysticercosis. Little is known about the time cysts take to progress through each phase, with or without treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reconfigured brain imaging data from patient level to cyst level for 117 patients in a randomized clinical trial of albendazole in which images were taken at baseline, 1, 6, 12 and 24 mo. Applying a multistate model, we modelled the hazard of a cyst evolving to subsequent cyst phases before the next imaging (vs no change). We examined the impact of albendazole treatment overall and by patient and cyst characteristics on the hazard.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Albendazole accelerated the evolution from the active to degenerative phase (HR=2.7, 95% CI 1.3 to 6.5) and from the degenerative phase to disappearance (HR=1.9, 95% CI 1.1 to 3.9). Albendazole\u2019s impact was stronger for patients who were male, did not have calcified cysts at baseline and who had multiple cysts in different locations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This research provides a better understanding of where in the cyst trajectory albendazole has the greatest impact.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trz073","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T07:10:21Z","timestamp":1562569821000},"page":"781-788","source":"Crossref","is-referenced-by-count":15,"title":["A longitudinal analysis of albendazole treatment effect on neurocysticercosis cyst evolution using multistate models"],"prefix":"10.1093","volume":"113","author":[{"given":"Michelle A","family":"Montgomery","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, CUNY Graduate School of Public Health and Health Policy, City University of New York, 55 West 125th Street, New York, New York 10027, USA"},{"name":"CUNY Institute for Implementation Science in Population Health, City University of New York, 55 West 125th Street, New York, New York 10027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, CUNY Graduate School of Public Health and Health Policy, City University of New York, 55 West 125th Street, New York, New York 10027, USA"},{"name":"CUNY Institute for Implementation Science in Population Health, City University of New York, 55 West 125th Street, New York, New York 10027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Kelvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, CUNY Graduate School of Public Health and Health Policy, City University of New York, 55 West 125th Street, New York, New York 10027, USA"},{"name":"CUNY Institute for Implementation Science in Population Health, City University of New York, 55 West 125th Street, New York, New York 10027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Carpio","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Cuenca, Av 12 de Abril s\/n Ciudadela Universitaria, 010201 Cuenca, Ecuador"},{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, 630 168th Street, Columbia University, New York, New York 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Instituto de Diagn\u00f3stico por Im\u00e1genes, In\u00e9s Salcedo 1-99, Cuenca, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Allen","family":"Hauser","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, 630 168th Street, Columbia University, New York, New York 10032, USA"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, New York 10032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, CUNY Graduate School of Public Health and Health Policy, City University of New York, 55 West 125th Street, New York, New York 10027, USA"},{"name":"CUNY Institute for Implementation Science in Population Health, City University of New York, 55 West 125th Street, New York, New York 10027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"2019121207372952400_ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40249-017-0245-y","article-title":"The causal relationship between neurocysticercosis infection and the development of epilepsy - a systematic review","volume":"6","author":"Gripper","year":"2017","journal-title":"Infect Dis Poverty."},{"key":"2019121207372952400_ref2"},{"key":"2019121207372952400_ref3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S0317167100048757","article-title":"A proposal for classification of neurocysticercosis","volume":"21","author":"Carpio","year":"1994","journal-title":"Can J Neurol Sci."},{"key":"2019121207372952400_ref4","first-page":"27","volume-title":"Cysticercosis of the Central Nervous 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Parasitol."},{"key":"2019121207372952400_ref29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.nic.2012.05.004","article-title":"Imaging of neurocysticercosis","volume":"22","author":"Lerner","year":"2012","journal-title":"Neuroimaging Clin N Am."},{"key":"2019121207372952400_ref30","doi-asserted-by":"crossref","DOI":"10.1201\/9781315374321","volume-title":"Multistate Survival Models for Interval-Censored Data","author":"Hout","year":"2016"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and 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