{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:00:07Z","timestamp":1768888807711,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study adds to the body of knowledge on differences that exist between different age groups in ATL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trz095","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:14:59Z","timestamp":1565378099000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro"],"prefix":"10.1093","author":[{"given":"Tatiana C R","family":"Senna","sequence":"first","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria In\u00eas F","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane F A","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo R","family":"Lyra","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio N","family":"Saheki","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza M","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia M","family":"Valete-Rosalino","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina C","family":"Martins","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando O","family":"Schubach","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro J","family":"Bedoya-Pacheco","sequence":"additional","affiliation":[{"name":"Avenida Leopoldo Bulh\u00f5es 1480, Manguinhos, Rio de Janeiro, RJ, CEP 21041210"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"2019111507002527200_ref1","volume-title":"Plan of action to strengthen the surveillance and control of leishmaniasis in the Americas 2017\u20132022","author":"Pan-American Health Organization","year":"2017"},{"key":"2019111507002527200_ref2","volume-title":"Manual de vigil\u00e2ncia da leishmaniose tegumentar","author":"Sa\u00fade","year":"2017"},{"issue":"Suppl 2","key":"2019111507002527200_ref3","first-page":"359","article-title":"Tegumentary and visceral leishmaniases in Brazil: Emerging anthropozoonosis and possibilities for their control","volume":"10","author":"Marzochi","year":"1994"},{"issue":"4","key":"2019111507002527200_ref4","first-page":"317","article-title":"Leishmania (Viannia) braziliensis genotypes identified in lesions of patients with atypical or typical 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(Psychodidae: Phlebotominae)","volume":"47","author":"Peterson","year":"2017"},{"issue":"6","key":"2019111507002527200_ref23","first-page":"1018","article-title":"Persistence of leishmania parasites in scars after clinical cure of American cutaneous leishmaniasis: Is there a sterile cure?","volume":"189","author":"Mendon\u00e7a","year":"2004"},{"issue":"5","key":"2019111507002527200_ref24","first-page":"593","article-title":"Clinical, laboratory, and therapeutic characteristics of American tegumentary leishmaniasis in the 15th state health division, Northwest Paran\u00e1 state, southern Brazil","volume":"49","author":"Nassif","year":"2016"},{"key":"2019111507002527200_ref25","first-page":"71","article-title":"Status of the american tegumentary leishmaniasis in the state of Rio de Janeiro, Brazil, from 2004 to 2013","volume":"58","author":"Vita","year":"2016"},{"key":"2019111507002527200_ref26","first-page":"709","article-title":"Epidemiology of cutaneous leishmaniasis in Colombia:Environmental and behavioral risk factors for infection, clinical manifestations, and pathogenicity","volume":"168","author":"Weigle","year":"1993"},{"key":"2019111507002527200_ref27","first-page":"171","article-title":"Gender and cutaneous leishmaniasis in Colombia","volume":"17","author":"Velez","year":"2001"},{"issue":"3","key":"2019111507002527200_ref28","first-page":"489","article-title":"Social and economic burden of human leishmaniasis","volume":"94","author":"Okwor","year":"2016"},{"issue":"5","key":"2019111507002527200_ref29","first-page":"445","article-title":"Estudo das caracter\u00edsticas epidemiol\u00f3gicas e cl\u00ednicas de 332 casos de leishmaniose tegumentar notificados na regi\u00e3o norte do Estado do Paran\u00e1 de 1993 a 1998","volume":"35","author":"Castro","year":"2002"},{"issue":"6","key":"2019111507002527200_ref30","first-page":"1291","article-title":"Distribui\u00e7\u00e3o geogr\u00e1fica e caracter\u00edsticas epidemiol\u00f3gicas da leishmaniose tegumentar Americana em \u00e1reas de coloniza\u00e7\u00e3o antiga do Estado do Paran\u00e1, Sul do Brasil","volume":"24","author":"Monteiro","year":"2008"}],"container-title":["Transactions of The Royal Society of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/trstmh\/advance-article-pdf\/doi\/10.1093\/trstmh\/trz095\/30795160\/trz095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/trstmh\/advance-article-pdf\/doi\/10.1093\/trstmh\/trz095\/30795160\/trz095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T12:00:43Z","timestamp":1573819243000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/trstmh\/advance-article\/doi\/10.1093\/trstmh\/trz095\/5614969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1093\/trstmh\/trz095","relation":{},"ISSN":["0035-9203","1878-3503"],"issn-type":[{"value":"0035-9203","type":"print"},{"value":"1878-3503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]},"article-number":"trz095"}}