{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:54:24Z","timestamp":1786964064423,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Urogenital schistosomiasis (UGS) causes inflammation and fibrosis of the urinary tract. In resource-limited settings, affordable tools for morbidity assessment in clinical care are needed. Point-of-care ultrasound has not yet been validated for UGS-related pathology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We developed a protocol for Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS), assessing pathology of the bladder wall, ureters and kidneys. Following standardized training, two clinicians performed FASUS on children and adults with hematuria in Lambar\u00e9n\u00e9, Gabon. Recorded ultrasound clips were remotely reviewed by two ultrasound experts as a diagnostic reference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 2015 and 2016, scans were performed in 118 patients. The image quality was sufficient in 90% of bladder views and more than 97% of kidney views. UGS-compatible pathology was detected in 51\/118 (43%) by the operator and in 46\/107 (43%) by the experts among baseline scans of sufficient quality. Inter-rater agreement between operators and experts was very good (\u03ba\u00a0&gt;\u00a00.8) for hydronephrosis and good (\u03ba\u00a0&gt;\u00a00.6) for bladder wall thickening.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FASUS is a promising clinical, point-of-care tool for detecting UGS-related urinary tract morbidity in symptomatic patients. Based on larger validation studies, appropriate diagnostic and therapeutic algorithms for the use of FASUS should be established.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trz101","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T11:38:07Z","timestamp":1567769887000},"source":"Crossref","is-referenced-by-count":7,"title":["Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)\u2014pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings"],"prefix":"10.1093","author":[{"given":"J","family":"Remppis","sequence":"first","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Haematology and Oncology, Children's University Hospital, Hoppe-Seyler-Stra\u00dfe 1, 72076 T\u00fcbingen, Germany"},{"name":"Institute of Tropical Medicine, University of T\u00fcbingen, Wilhelmstra\u00dfe 27, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Verheyden","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Bustinduy","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Heller","sequence":"additional","affiliation":[{"name":"Lighthouse Clinic, Kamuzu Central Hospital, Area 33 Mzimba Street. P.O. Box 106, Lilongwe, Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Garc\u00eda-Tard\u00f3n","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Clinical Chemistry Laboratory, Isala, Dr. van Heesweg 2, 8025 AB Zwolle, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Manouana","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, University of T\u00fcbingen, Wilhelmstra\u00dfe 27, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Obiang","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Adegnika","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, University of T\u00fcbingen, Wilhelmstra\u00dfe 27, 72074 T\u00fcbingen, Germany"},{"name":"German Center for Infection Research, Wilhelmstra\u00dfe 27, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Grobusch","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, University of T\u00fcbingen, Wilhelmstra\u00dfe 27, 72074 T\u00fcbingen, Germany"},{"name":"Center of Tropical Medicine and Travel Medicine, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ramharter","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I Department of Medicine University Medical Center Hamburg-Eppendorf, Bernhard-Nocht-Stra\u00dfe 74, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Joekes","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine, Pembroke Pl, Liverpool L3 5QA, UK"},{"name":"Department of Radiology, Royal Liverpool University Hospital NHS Trust, Prescot St, Liverpool L7 8XP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"B\u00e9lard","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 (CERMEL), B.P: 242 Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Paediatric Pulmonology, Immunology and Intensive Care Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Augustenburgerplatz 1, 10117 Berlin, Germany"},{"name":"Berlin Institute of Health, Anna-Louisa-Karsch-Stra\u00dfe 2, 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,16]]},"reference":[{"key":"2019112005414545700_ref1","author":"WHO. 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