{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:39:16Z","timestamp":1787751556170,"version":"build-2784847793"},"reference-count":23,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cystic echinococcosis (CE) is a chronic, complex and neglected zoonotic disease caused by Echinococcus granulosus. Eosinophilia in CE is a classic analytic alteration, although its presentation and importance is very variable and not well established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective observational study of inpatients diagnosed with CE and eosinophilia from January 1998 to December 2017 in the Complejo Asistencial Universitario de Salamanca in western Spain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, 475 patients with a CE diagnosis underwent a haemogram and 118 (24.8%) patients had eosinophilia. Eighty-two (69.5%) were male and the mean age was 52.1\u00b120.8\u00a0y, which was younger in the group with eosinophilia (p&lt;0.001). The patients with eosinophilia had less comorbidity (33.1% vs 52.9%; p&lt;0.001) and they were diagnosed with more complications (60.2% vs 39.8% asymptomatic; p&lt;0.001). Clinical manifestations appeared in 71 cases (60.2%). The eosinophilia was related to the presence of pre-surgical fistulas (p=0.005). We observed significant differences when considering whether eosinophilia is a marker of the type of treatment (p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Eosinophilia can be an indicator for an active search in CE because as much as 40% of cases are asymptomatic at diagnosis. In patients with eosinophilia, management is usually more aggressive and is usually a combined treatment. Our work shows the importance of eosinophilia in our patients with CE and raises unresolved questions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/trstmh\/trz105","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T11:38:07Z","timestamp":1567769887000},"source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilia and cystic echinococcosis: what is the relationship?"],"prefix":"10.1093","author":[{"given":"Javier","family":"Collado-Aliaga","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Romero-Alegr\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alonso-Sard\u00f3n","sequence":"additional","affiliation":[{"name":"\u00c1rea de Medicina Preventiva y Salud P\u00fablica, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"L\u00f3pez-Bernus","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Secci\u00f3n de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Galindo-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n Primaria, Puente San Miguel, Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Muro","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Parasitaria y Molecular, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Velasco-Tirado","sequence":"additional","affiliation":[{"name":"Servicio de Dermatolog\u00eda, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Mu\u00f1oz Bellido","sequence":"additional","affiliation":[{"name":"Servicio de Microbiologia, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Belhassen-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Secci\u00f3n de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Paseo San Vicente 58-182, 37007, Salamanca, 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