{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:06:03Z","timestamp":1770566763153,"version":"3.49.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41421001"],"award-info":[{"award-number":["41421001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41531179"],"award-info":[{"award-number":["41531179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology of China","award":["2016YFC1302504"],"award-info":[{"award-number":["2016YFC1302504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Enterovirus 71 (EV71) can cause large outbreaks of hand, foot, and mouth disease (HFMD) and severe neurological diseases, which is regarded as a major threat to public health, especially in Asia-Pacific regions. However, the global spatiotemporal spread of this virus has not been identified. In this study, we used large sequence datasets and a Bayesian phylogenetic approach to compare the molecular epidemiology and geographical spread patterns of different EV71 subgroups globally. The study found that subgroups of HFMD presented global spatiotemporal variation, subgroups B0, B1, and B2 have caused early infections in Europe and America, and then subgroups C1, C2, C3, and C4 replaced B0-B2 as the predominant genotypes, especially in Asia-Pacific countries. The dispersal patterns of genotype B and subgroup C4 showed the complicated routes in Asia and the source might in some Asian countries, while subgroups C1 and C2 displayed more strongly supported pathways globally, especially in Europe. This study found the predominant subgroup of EV71 and its global spatiotemporal transmission patterns, which may be beneficial to reveal the long-term global spatiotemporal transmission patterns of human EV71 and carry out the HFMD vaccine development.<\/jats:p>","DOI":"10.1093\/ve\/veab071","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T09:12:10Z","timestamp":1628845930000},"source":"Crossref","is-referenced-by-count":6,"title":["Global spatiotemporal transmission patterns of human enterovirus 71 from 1963 to 2019"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-3993","authenticated-orcid":false,"given":"Bing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Xi\u2019an Jiaotong University , 277, Yanta West Road, Xi\u2019an, 710061, China"},{"name":"The State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences , 11A, Datun Road, Chaoyang District, Beijing, 100101, China"},{"name":"Sino-Danish College, University of Chinese Academy of Sciences , 19A, Yuquan Road, Beijing, 100190, China"},{"name":"Key Clinical Discipline by National Health Commission , 277, Yanta West Road, Xi\u2019an, 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-9420","authenticated-orcid":false,"given":"Jinfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences , 11A, Datun Road, Chaoyang District, Beijing, 100101, China"},{"name":"Sino-Danish College, University of Chinese Academy of Sciences , 19A, Yuquan Road, Beijing, 100190, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences , 11A, Datun Road, Chaoyang District, Beijing, 100101, China"},{"name":"Sino-Danish College, University of Chinese Academy of Sciences , 19A, Yuquan Road, Beijing, 100190, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengdong","family":"Xu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences , 11A, Datun Road, Chaoyang District, Beijing, 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yin","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences , 11A, Datun Road, Chaoyang District, Beijing, 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Oceanography and Space Informatics, China University of Petroleum , 66 Changjiangxi Road, Huangdao District, Qingdao, 266580, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"2024051502212269100_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(99)00019-2","article-title":"Identification of Enterovirus 71 Isolates from an Outbreak of Hand, Foot and Mouth Disease (HFMD) with Fatal Cases of Encephalomyelitis in Malaysia","volume":"61","author":"AbuBakar","year":"1999","journal-title":"Virus Research"},{"key":"2024051502212269100_R2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3201\/eid1501.080264","article-title":"Enterovirus 71 Outbreak, Brunei","volume":"15","year":"2009","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/infdis\/169.4.905","article-title":"Enterovirus 71 Infections and Neurologic Disease\u2014United States, 1977\u20131991","volume":"169","author":"Alexander","year":"1997","journal-title":"The Journal of Infectious Diseases"},{"key":"2024051502212269100_R4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090624","article-title":"Molecular Comparison and Evolutionary Analyses of VP1 Nucleotide Sequences of New African Human Enterovirus 71 Isolates Reveal a Wide Genetic Diversity","volume":"9","author":"Bessaud","year":"2014","journal-title":"PLoS One"},{"key":"2024051502212269100_R5","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1093\/bioinformatics\/btr481","article-title":"SPREAD: Spatial Phylogenetic Reconstruction of Evolutionary Dynamics","volume":"27","author":"Bielejec","year":"2011","journal-title":"Bioinformatics"},{"key":"2024051502212269100_R6","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular Epidemiology and Evolution of Enterovirus 71 Strains Isolated from 1970 to 1998","volume":"73","author":"Brown","year":"1999","journal-title":"Journal of Virology"},{"key":"2024051502212269100_R7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0168-1702(95)00087-9","article-title":"Complete Nucleotide Sequence of Enterovirus 71 Is Distinct from Poliovirus","volume":"39","author":"Brown","year":"1995","journal-title":"Virus Research"},{"key":"2024051502212269100_R8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes","volume":"9","author":"Cardosa","year":"2003","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R9","first-page":"451","article-title":"Comparative Genetic Analysis of VP4, VP1 and 3D Gene Regions of Enterovirus 71 and Coxsackievirus A16 Circulating in Malaysia between 1997\u20132008","volume":"29","author":"Chan","year":"2012","journal-title":"Tropical Biomedicine"},{"key":"2024051502212269100_R10","doi-asserted-by":"crossref","DOI":"10.1590\/s1678-9946201860070","article-title":"Hand, Foot and Mouth Disease and Herpangina Caused by Enterovirus A71 Infections: A Review of Enterovirus A71 Molecular Epidemiology, Pathogenesis, and Current Vaccine Development","volume":"60","author":"Chang","year":"2018","journal-title":"Revista Do Instituto De Medicina Tropical De Sao Paulo"},{"key":"2024051502212269100_R11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7883\/yoken.63.229","article-title":"Clinical and Molecular Characterization of Hand-foot-and-mouth Disease in Thailand, 2008\u20132009","volume":"63","author":"Chatproedprai","year":"2010","journal-title":"Japanese Journal of Infectious Diseases"},{"key":"2024051502212269100_R12","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00316-16","article-title":"Full-Genome Sequences of Seven Fatal Enterovirus 71 Strains Isolated in Shenzhen, China, in 2014","volume":"4","author":"Chen","year":"2016","journal-title":"Genome Announcements"},{"key":"2024051502212269100_R13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s007050170164","article-title":"Molecular Epidemiology of Enterovirus 71 in Taiwan","volume":"146","author":"Chu","year":"2001","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00705-011-0929-8","article-title":"A Large Outbreak of Hand, Foot, and Mouth Disease Caused by EV71 and CAV16 in Guangdong, China, 2009","volume":"156","author":"De","year":"2011","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R15","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00705-009-0413-x","article-title":"Seroprevalence and Molecular Epidemiology of Enterovirus 71 in Germany","volume":"154","author":"Diedrich","year":"2009","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.virusres.2009.06.006","article-title":"Appearance of Mosaic Enterovirus 71 in the 2008 Outbreak of China","volume":"145","author":"Ding","year":"2009","journal-title":"Virus Research"},{"key":"2024051502212269100_R17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1371\/journal.pbio.0040088","article-title":"Relaxed Phylogenetics and Dating with Confidence","volume":"4","author":"Drummond","year":"2006","journal-title":"PLoS Biology"},{"key":"2024051502212269100_R18","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2016.101","article-title":"Molecular Epidemiology of Human Enterovirus 71 at the Origin of an Epidemic of Fatal Hand, Foot and Mouth Disease Cases in Cambodia","volume":"5","author":"Duong","year":"2016","journal-title":"Emerging Microbes and Infections"},{"key":"2024051502212269100_R19","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-017-2427-4","article-title":"Valine\/isoleucine Variants Drive Selective Pressure in the VP1 Sequence of EV-A71 Enteroviruses","volume":"17","author":"Duy","year":"2017","journal-title":"BMC Infectious Diseases"},{"key":"2024051502212269100_R20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3201\/eid2204.151588","article-title":"Enterovirus A71 Genogroups C and E in Children with Acute Flaccid Paralysis, West Africa","volume":"22","author":"Fernandez-Garcia","year":"2016","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R21","article-title":"National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016","author":"Fu","year":"2019","journal-title":"Virologica Sinica"},{"key":"2024051502212269100_R22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00006454-198807000-00007","article-title":"Outbreak of Enterovirus 71 Infection in Victoria, Australia, with a High Incidence of Neurologic Involvement","volume":"7","author":"Gilbert","year":"1988","journal-title":"Pediatric Infectious Disease"},{"key":"2024051502212269100_R23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1348-0421.1977.tb00282.x","article-title":"Properties of Virus Isolated from an Epidemic of Hand-Foot-and-Mouth Disease in 1973 in the City of Matsue","volume":"21","author":"Gobara","year":"1977","journal-title":"Microbiology and Immunology"},{"key":"2024051502212269100_R24","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1073\/pnas.1401884111","article-title":"The Irish Potato Famine Pathogen Phytophthora Infestans Originated in Central Mexico Rather than the Andes","volume":"111","author":"Goss","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2024051502212269100_R25","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2015.20.34.30005","article-title":"Transmission Patterns of Human Enterovirus 71 To, from and among European Countries, 2003 to 2013","volume":"20","author":"Hassel","year":"2015","journal-title":"Eurosurveillance"},{"key":"2024051502212269100_R26","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00705-003-0100-2","article-title":"Molecular Epidemiology of Enterovirus 71 in Peninsular Malaysia, 1997\u20132000","volume":"148","author":"Herrero","year":"2003","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An Epidemic of Enterovirus 71 Infection in Taiwan","volume":"341","author":"Ho","year":"1999","journal-title":"The New England Journal of Medicine"},{"key":"2024051502212269100_R28","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/infdis\/jiv094","article-title":"A Potent Virus-Specific Antibody-Secreting Cell Response to Acute Enterovirus 71 Infection in Children","volume":"212","author":"Huang","year":"2015","journal-title":"The Journal of Infectious Diseases"},{"key":"2024051502212269100_R29","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0574-1","article-title":"Enterovirus A71: Virulence, Antigenicity, and Genetic Evolution over the Years","volume":"26","author":"Huang","year":"2019","journal-title":"Journal of Biomedical Science"},{"key":"2024051502212269100_R30","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1128\/JCM.00630-09","article-title":"Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008","volume":"47","author":"Huang","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"key":"2024051502212269100_R31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.virusres.2008.07.015","article-title":"The Circulation of Subgenogroups B5 and C5 of Enterovirus 71 in Taiwan from 2006 to 2007","volume":"137","author":"Huang","year":"2008","journal-title":"Virus Research"},{"key":"2024051502212269100_R32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/adc.55.8.583","article-title":"Outbreaks of Hand, Foot, and Mouth Disease by Enterovirus 71. High Incidence of Complication Disorders of Central Nervous System","volume":"55","author":"Ishimaru","year":"1980","journal-title":"Archives of Disease in Childhood"},{"key":"2024051502212269100_R33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7883\/yoken.JJID.2009.254","article-title":"Genetic Changes of Coxsackievirus A16 and Enterovirus 71 Isolated from Hand, Foot, and Mouth Disease Patients in Toyama, Japan between 1981 and 2007","volume":"62","author":"Iwai","year":"2009","journal-title":"Japanese Journal of Infectious Diseases"},{"key":"2024051502212269100_R34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00705-003-0133-6","article-title":"Genetic Analysis of the VP1 Region of Human Enterovirus 71 Strains Isolated in Korea during 2000","volume":"148","author":"Jee","year":"2003","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R35","first-page":"609","article-title":"Enterovirus Type 71 Infection in Melbourne","volume":"51","author":"Kennett","year":"1973","journal-title":"Bulletin of the World Health Organization"},{"key":"2024051502212269100_R36","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Molecular Biology and Evolution"},{"key":"2024051502212269100_R37","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1469-0691.2007.01745.x","article-title":"Genetic and Antigenic Analyses of Enterovirus 71 Isolates in Taiwan during 1998\u20132005","volume":"13","author":"Kung","year":"2007","journal-title":"Clinical Microbiology and Infection"},{"key":"2024051502212269100_R38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001737","article-title":"Challenges to Licensure of Enterovirus 71 Vaccines","volume":"6","author":"Lee","year":"2012","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"2024051502212269100_R39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000520","article-title":"Bayesian Phylogeography Finds Its Roots","volume":"5","author":"Lemey","year":"2009","journal-title":"PLoS Computational Biology"},{"key":"2024051502212269100_R40","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01375-14","article-title":"Complete Genome Sequence of Human Enterovirus Strain 71 (Ev71\/taipei\/3118\/2011), Isolated from a Patient in Taiwan","volume":"3","author":"Lin","year":"2015","journal-title":"Genome Announcements"},{"key":"2024051502212269100_R41","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jmv.20534","article-title":"Evolution of EV71 Genogroup in Taiwan from 1998 to 2005: An Emerging of Subgenogroup C4 of EV71","volume":"78","author":"Lin","year":"2006","journal-title":"Journal of Medical Virology"},{"key":"2024051502212269100_R42","doi-asserted-by":"crossref","DOI":"10.1186\/1423-0127-21-16","article-title":"Epidemiology and Seroepidemiology of Human Enterovirus 71 among Thai Populations","volume":"21","author":"Linsuwanon","year":"2014","journal-title":"Journal of Biomedical Science"},{"key":"2024051502212269100_R43","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1016\/j.vaccine.2011.04.010","article-title":"Identification and Characterization of a Cross-neutralization Epitope of Enterovirus 71","volume":"29","author":"Liu","year":"2011","journal-title":"Vaccine"},{"key":"2024051502212269100_R44","article-title":"Characterization of an Outbreak of Hand, Foot, and Mouth Disease in Nanchang, China in 2010","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"2024051502212269100_R45","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1099\/vir.0.060004-0","article-title":"Recombination Strategies and Evolutionary Dynamics of the Human Enterovirus A Global Gene Pool","volume":"95","author":"Lukashev","year":"2014","journal-title":"The Journal of General Virology"},{"key":"2024051502212269100_R46","doi-asserted-by":"crossref","DOI":"10.1145\/2818302","article-title":"Reemergence of Enterovirus 71 Epidemic in Northern Taiwan, 2012","volume":"10","author":"Luo","year":"2015","journal-title":"PLoS One"},{"key":"2024051502212269100_R47","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy250","article-title":"Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations","volume":"5","author":"Majumdar","year":"2018","journal-title":"Open Forum Infectious Diseases"},{"key":"2024051502212269100_R48","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jcv.2010.07.009","article-title":"Epidemiology of Hand, Foot, and Mouth Disease and Genotype Characterization of Enterovirus 71 in Jiangsu, China","volume":"49","author":"Mao","year":"2010","journal-title":"Journal of Clinical Virology"},{"key":"2024051502212269100_R49","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic Analysis of Enterovirus 71 Strains Isolated during Linked Epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"McMinn","year":"2001","journal-title":"Journal of Virology"},{"key":"2024051502212269100_R50","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/molbev\/msn090","article-title":"Smooth Skyride through a Rough Skyline: Bayesian Coalescent-based Inference of Population Dynamics","volume":"25","author":"Minin","year":"2008","journal-title":"Molecular Biology and Evolution"},{"key":"2024051502212269100_R51","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1099\/vir.0.021741-0","article-title":"Phylogenetic Evidence for a Recent Spread of Two Populations of Human Enterovirus 71 in European Countries","volume":"91","author":"Mirand","year":"2010","journal-title":"Journal of General Virology"},{"key":"2024051502212269100_R52","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1128\/JCM.43.12.6171-6175.2005","article-title":"Frequent Importation of Enterovirus 71 from Surrounding Countries into the Local Community of Yamagata, Japan, between 1998 and 2003","volume":"43","author":"Mizuta","year":"2005","journal-title":"Journal of Clinical Microbiology"},{"key":"2024051502212269100_R53","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1099\/jmm.0.079699-0","article-title":"Molecular Epidemiology of Enterovirus 71 Strains Isolated from Children in Yamagata, Japan, between 1990 and 2013","volume":"63","year":"2014","journal-title":"Journal of Medical Microbiology"},{"key":"2024051502212269100_R54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01314873","article-title":"Virological Diagnosis of Enterovirus Type 71 Infections: Experiences Gained during an Epidemic of Acute CNS Diseases in Hungary in 1978","volume":"71","author":"Nagy","year":"1982","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R55","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/s41559-017-0280-x","article-title":"A Biologist\u2019s Guide to Bayesian Phylogenetic Analysis","volume":"1","author":"Nascimento","year":"2017","journal-title":"Nature Ecology and Evolution"},{"key":"2024051502212269100_R56","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-016-0580-9","article-title":"Development and Evaluation of a Non-ribosomal Random PCR and Next-generation Sequencing Based Assay for Detection and Sequencing of Hand, Foot and Mouth Disease Pathogens","volume":"13","author":"Nguyen","year":"2016","journal-title":"Virology Journal"},{"key":"2024051502212269100_R57","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1128\/JVI.00837-12","article-title":"Characterizing the Picornavirus Landscape among Synanthropic Nonhuman Primates in Bangladesh, 2007 to 2008","volume":"87","author":"Oberste","year":"2013","journal-title":"Journal of Virology"},{"key":"2024051502212269100_R58","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3201\/eid2407.171923","article-title":"Enterovirus A71 Infection, Thailand, 2017","volume":"24","author":"Puenpa","year":"2018","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R59","article-title":"The History of Enterovirus A71 Outbreaks and Molecular Epidemiology in the Asia-Pacific Region","volume":"26","year":"2019","journal-title":"Journal of Biomedical Science"},{"key":"2024051502212269100_R60","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vew007","article-title":"Exploring the Temporal Structure of Heterochronous Sequences Using TempEst (Formerly Path-O-Gen)","volume":"2","author":"Rambaut","year":"2016","journal-title":"Virus Evolution"},{"key":"2024051502212269100_R61","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3201\/eid1811.111457","article-title":"Antigenic Diversity of Enteroviruses Associated with Nonpolio Acute Flaccid Paralysis, India, 2007\u20132009","volume":"18","author":"Rao","year":"2012","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R62","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00006454-198702000-00013","article-title":"Monoplegia Caused by Enterovirus 71: An Outbreak in Hong Kong","volume":"6","author":"Samuda","year":"1987","journal-title":"Pediatric Infectious Disease"},{"key":"2024051502212269100_R63","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00705-005-0684-9","article-title":"Molecular Epidemiology of Enterovirus 71 over Two Decades in an Australian Urban Community","volume":"151","author":"Sanders","year":"2006","journal-title":"Archives of Virology"},{"key":"2024051502212269100_R64","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An Apparently New Enterovirus Isolated from Patients with Disease of the Central Nervous System","volume":"129","author":"Schmidt","year":"1974","journal-title":"Journal of Infectious Diseases"},{"key":"2024051502212269100_R65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/molbev\/msj021","article-title":"Choosing Appropriate Substitution Models for the Phylogenetic Analysis of Protein-coding Sequences","volume":"23","author":"Shapiro","year":"2006","journal-title":"Molecular Biology and Evolution"},{"key":"2024051502212269100_R66","first-page":"284","article-title":"Epidemiological, Clinical, and Pathomorphological Characteristics of Epidemic Poliomyelitis-like Disease Caused by Enterovirus 71","volume":"23","author":"Shindarov","year":"1979","journal-title":"Journal of Hygiene, Epidemiology, Microbiology, and Immunology"},{"key":"2024051502212269100_R67","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, Epidemiology, Pathogenesis, and Control of Enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infectious Diseases"},{"key":"2024051502212269100_R68","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vey016","article-title":"Bayesian Phylogenetic and Phylodynamic Data Integration Using BEAST 1.10","volume":"4","author":"Suchard","year":"2018","journal-title":"Virus Evolution"},{"key":"2024051502212269100_R69","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/oxfordjournals.molbev.a003872","article-title":"Bayesian Selection of Continuous-time Markov Chain Evolutionary Models","volume":"18","author":"Suchard","year":"2001","journal-title":"Molecular Biology and Evolution"},{"key":"2024051502212269100_R70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025662","article-title":"The Persistent Circulation of Enterovirus 71 in People\u2019s Republic of China: Causing Emerging Nationwide Epidemics since 2008","volume":"6","author":"Tan","year":"2011","journal-title":"PLoS One"},{"key":"2024051502212269100_R71","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/JVI.01019-09","article-title":"Evolutionary Genetics of Human Enterovirus 71: Origin, Population Dynamics, Natural Selection, and Seasonal Periodicity of the VP1 Gene","volume":"84","author":"Tee","year":"2010","journal-title":"Journal of Virology"},{"key":"2024051502212269100_R72","article-title":"Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011","volume":"8","author":"Thoa le","year":"2013","journal-title":"PLoS One"},{"key":"2024051502212269100_R73","doi-asserted-by":"crossref","DOI":"10.3390\/v11100895","article-title":"Using Statistical Phylogenetics for Investigation of Enterovirus 71 Genotype A Reintroduction into Circulation","volume":"11","author":"Vakulenko","year":"2019","journal-title":"Viruses"},{"key":"2024051502212269100_R74","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3201\/eid1511.090493","article-title":"Fatal Case of Enterovirus 71 Infection, France, 2007","volume":"15","author":"Vallet","year":"2009","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R75","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1128\/JCM.00507-09","article-title":"Epidemiology of Enterovirus 71 in the Netherlands, 1963 to 2008","volume":"47","author":"van der Sanden","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"key":"2024051502212269100_R76","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1099\/vir.0.019695-0","article-title":"Evolutionary Trajectory of the VP1 Gene of Human Enterovirus 71 Genogroup B and C Viruses","volume":"91","year":"2010","journal-title":"The Journal of General Virology"},{"key":"2024051502212269100_R77","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005","volume":"13","author":"Van Tu","year":"2007","journal-title":"Emerging Infectious Diseases"},{"key":"2024051502212269100_R78","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-015-0308-2","article-title":"Enterovirus 71 Infection in Children with Hand, Foot, and Mouth Disease in Shanghai, China: Epidemiology, Clinical Feature and Diagnosis","volume":"12","author":"Wang","year":"2015","journal-title":"Virology Journal"},{"key":"2024051502212269100_R79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virusres.2006.07.015","article-title":"Asymptomatic Circulation of HEV71 in Norway","volume":"123","author":"Witso","year":"2007","journal-title":"Virus Research"},{"key":"2024051502212269100_R80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1386-6532(00)00067-6","article-title":"An Outbreak of Enterovirus 71 Infection in Taiwan 1998: A Comprehensive Pathological, Virological, and Molecular Study on a Case of Fulminant Encephalitis","volume":"17","author":"Yan","year":"2000","journal-title":"Journal of Clinical Virology"},{"key":"2024051502212269100_R81","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 Outbreak in the People\u2019s Republic of China in 2008","volume":"47","author":"Yang","year":"2009","journal-title":"Journal of Clinical Microbiology"},{"key":"2024051502212269100_R82","article-title":"Survey of Enterovirus Infections from Hand, Foot and Mouth Disease Outbreak in China, 2009","volume":"8","year":"2011","journal-title":"Virology Journal"},{"key":"2024051502212269100_R83","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01112-13","article-title":"Complete Genome Sequence of a Human Enterovirus 71 Strain Isolated in Wuhan, China, in 2010","volume":"1","author":"Yang","year":"2013","journal-title":"Genome Announcements"},{"key":"2024051502212269100_R84","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2180-6-74","article-title":"Phylogenetic Evidence for Inter-typic Recombination in the Emergence of Human Enterovirus 71 Subgenotypes","volume":"6","author":"Yoke-Fun","year":"2006","journal-title":"BMC Microbiology"},{"key":"2024051502212269100_R85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-010-0472-9","article-title":"Genetic Analysis of the VP1 Region of Enterovirus 71 Reveals the Emergence of Genotype A in Central China in 2008","volume":"41","author":"Yu","year":"2010","journal-title":"Virus Genes"},{"key":"2024051502212269100_R86","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","article-title":"An Outbreak of Hand, Foot, and Mouth Disease Associated with Subgenotype C4 of Human Enterovirus 71 in Shandong, China","volume":"44","author":"Zhang","year":"2009","journal-title":"Journal of Clinical Virology"},{"key":"2024051502212269100_R87","article-title":"An Emerging Recombinant Human Enterovirus 71 Responsible for the 2008 Outbreak of Hand Foot and Mouth Disease in Fuyang City of China","volume":"7","year":"2010","journal-title":"Virology Journal"}],"container-title":["Virus Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ve\/advance-article-pdf\/doi\/10.1093\/ve\/veab071\/40073846\/veab071.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ve\/article-pdf\/7\/2\/veab071\/57659739\/veab071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ve\/article-pdf\/7\/2\/veab071\/57659739\/veab071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T02:22:46Z","timestamp":1715739766000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ve\/article\/doi\/10.1093\/ve\/veab071\/6350448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,9,14]]}},"URL":"https:\/\/doi.org\/10.1093\/ve\/veab071","relation":{},"ISSN":["2057-1577"],"issn-type":[{"value":"2057-1577","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12]]},"published":{"date-parts":[[2021,8,13]]},"article-number":"veab071"}}