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While TBEV is typically classified into three subtypes, recent evidence suggests a more varied range of TBEV subtypes and lineages that differ substantially in the architecture of their 3\u02b9 untranslated region (3\u02b9UTR). Building on comparative genomic approaches and thermodynamic modelling, we characterize the TBEV UTR structureome diversity and propose a unified picture of pervasive non-coding RNA structure conservation. Moreover, we provide an updated phylogeny of TBEV, building on more than 220 publicly available complete genomes, and investigate the molecular epidemiology and phylodynamics with Nextstrain, a web-based visualization framework for real-time pathogen evolution.<\/jats:p>","DOI":"10.1093\/ve\/veac051","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T13:17:11Z","timestamp":1656940631000},"source":"Crossref","is-referenced-by-count":22,"title":["Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology"],"prefix":"10.1093","volume":"8","author":[{"given":"Lena S","family":"Kutschera","sequence":"first","affiliation":[{"name":"Department of Theoretical Chemistry, University of Vienna , W\u00e4hringer Stra\u00dfe 17, Vienna 1090, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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