{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:33:28Z","timestamp":1792812808343,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":96,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing compared to MPXV genomes collected earlier. It is unclear whether these single-nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.<\/jats:p>","DOI":"10.1093\/ve\/vead058","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:34:24Z","timestamp":1695083664000},"source":"Crossref","is-referenced-by-count":7,"title":["The role of\u00a0APOBEC3-induced mutations in\u00a0the differential evolution of\u00a0monkeypox virus"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-7364","authenticated-orcid":false,"given":"Xiangting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Computational Medicine, UCLA , Los Angeles, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Habibipour","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA , Los Angeles, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-6349","authenticated-orcid":false,"given":"Tom","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Computational Medicine, UCLA , Los Angeles, CA, United States"},{"name":"Department of Mathematics, UCLA , Los Angeles, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto O","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA , Los Angeles, CA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"2023101216071853400_R1","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of\u00a0coupled chemical reactions","volume":"81","author":"D. 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