{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:45:49Z","timestamp":1792136749831,"version":"4.4.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In the USA, DENV-2 epidemics have been dominated by DENV-2 genotype Asian-American (DENV-2-GIII), and the first cases of DENV-2-GII were only described in 2019, in Peru, and in 2021 in Brazil. To gain new information about the circulation of DENV-2-GII in Brazil, we sequenced 237 DENV-2 confirmed cases sampled between March 2021 and March 2023 and revealed that DENV-2-GII is already present in all geographic regions of Brazil. The phylogeographic analysis inferred that DENV-2-GII was introduced at least four times in Brazil, between May 2020 and August 2022, generating multiple clades that spread throughout the country with different success. Despite multiple introductions of DENV-2-GII, analysis of the country-wide laboratory surveillance data showed that the Brazilian dengue epidemic in 2022 was dominated by DENV-1 in most states. We hypothesize that massive circulation of DENV-2-GIII in previous years in Brazil might have created a population immune barrier against symptomatic homotypic reinfections by DENV-2-GII, leading to sustained cryptic circulation in asymptomatic cases and localized outbreaks of this new genotype. In summary, our study stresses the importance of arboviral genomic surveillance to close monitoring and better understanding the potential impact of DENV-2-GII in the coming years.<\/jats:p>","DOI":"10.1093\/ve\/vead059","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T17:38:58Z","timestamp":1695231538000},"source":"Crossref","is-referenced-by-count":35,"title":["Multiple introductions and\u00a0country-wide spread of\u00a0DENV-2 genotype II (Cosmopolitan) in\u00a0Brazil"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-7975","authenticated-orcid":false,"given":"Tiago","family":"Gr\u00e4f","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas , Funda\u00e7\u00e3o Oswaldo Cruz, Curitiba 81350-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Do Nascimento","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas , Funda\u00e7\u00e3o Oswaldo Cruz, Curitiba 81350-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Barbosa","family":"de Lima","sequence":"additional","affiliation":[{"name":"N\u00facleo de Plataformas Tecnol\u00f3gicas (NPT), Instituto Aggeu Magalh\u00e3es (IAM), FIOCRUZ-Pernambuco , Recife, Pernambuco 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Em\u00eddio","family":"de Lima","sequence":"additional","affiliation":[{"name":"N\u00facleo de Plataformas Tecnol\u00f3gicas (NPT), Instituto Aggeu Magalh\u00e3es (IAM), FIOCRUZ-Pernambuco , Recife, Pernambuco 50740-465, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Ceschini","family":"Machado","sequence":"additional","affiliation":[{"name":"Departamento de Entomologia, Instituto Aggeu 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