{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:14:59Z","timestamp":1793045699699,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":151,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000877","name":"Rockefeller Foundation","doi-asserted-by":"publisher","award":["2021 HTH 018"],"award-info":[{"award-number":["2021 HTH 018"]}],"id":[{"id":"10.13039\/100000877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000877","name":"Rockefeller Foundation","doi-asserted-by":"publisher","award":["2021 HTH 018"],"award-info":[{"award-number":["2021 HTH 018"]}],"id":[{"id":"10.13039\/100000877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Monkeypox (MPOX), a zoonotic disease originating in Western and Central Africa in 1970, has seen a recent surge in outbreaks across 100+ countries. A comparative analysis of 404 Monkeypox virus (MPXV) genomes revealed notable changes in microsatellite abundance and density, especially within Clades I, IIa, and IIb. Each clade exhibited unique microsatellite motifs, with twenty-six conserved loci specific to MPXV, suggesting their potential as molecular markers in diagnostics. Additionally, nine genes in the MPXV genome featured ten variable hotspot microsatellite regions associated with surface protein synthesis and host control. Notably, gene OPG153, especially at the SSR locus \u2018(ATC)n\u2019, exhibited the most pronounced variations among lineages over time and plays a role in virus pathogenesis within the host cell. These findings not only enhance our understanding of MPXV unique molecular profile but also offer valuable insights into potential pathogenic and evolutionary implications.<\/jats:p>","DOI":"10.1093\/ve\/veae043","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T22:03:00Z","timestamp":1717192980000},"source":"Crossref","is-referenced-by-count":8,"title":["Comparative genome analysis reveals driving forces behind Monkeypox virus evolution and sheds light on the role of ATC trinucleotide motif"],"prefix":"10.1093","volume":"10","author":[{"given":"Preeti","family":"Agarwal","sequence":"first","affiliation":[{"name":"Bioinformatics and Big Data, CSIR-Institute of Genomics and Integrative Biology , Mall Road, Delhi 110007, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad, Uttar Pradesh 201002, 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-2861","authenticated-orcid":false,"given":"Jitendra","family":"Narayan","sequence":"additional","affiliation":[{"name":"Bioinformatics and Big Data, CSIR-Institute of Genomics and Integrative Biology , Mall Road, Delhi 110007, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad, Uttar Pradesh 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"2024053114571409800_R1","doi-asserted-by":"crossref","DOI":"10.1007\/s00203-023-03595-9","article-title":"Comparative Genomics Reveals the Presence of Simple Sequence Repeats in Genes Related to Virulence in Plant Pathogenic Pythium Ultimum and Pythium Vexans","volume":"205","author":"Alotaibi","year":"2023","journal-title":"Archives of Microbiology"},{"key":"2024053114571409800_R2","article-title":"Virulence 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