{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:25Z","timestamp":1790009545063,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":249,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2021MH242"],"award-info":[{"award-number":["ZR2021MH242"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2021MH242"],"award-info":[{"award-number":["ZR2021MH242"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The classification of severe fever with thrombocytopenia syndrome virus (SFTSV) lacked consistency due to limited virus sequences used across previous studies, and the origin and transmission dynamics of the SFTSV remains not fully understood. In this study, we analyzed the diversity and phylodynamics of SFTSV using the most comprehensive and largest dataset publicly available for a better understanding of SFTSV classification and transmission. A total of 1267\u2009L segments, 1289\u2009M segments, and 1438 S segments collected from China, South Korea, and Japan were included in this study. Maximum likelihood trees were reconstructed to classify the lineages. Discrete phylogeographic analysis was conducted to infer the phylodynamics of SFTSV. We found that the L, M, and S segments were highly conserved, with mean pairwise nucleotide distances of 2.80, 3.36, and 3.35% and could be separated into 16, 13, and 15 lineages, respectively. The evolutionary rate for L, M, and the S segment was 0.61\u2009\u00d7\u200910\u22124 (95% HPD: 0.48\u20130.73\u2009\u00d7\u200910\u22124), 1.31\u2009\u00d7\u200910\u22124 (95% HPD: 0.77\u20131.77\u2009\u00d7\u200910\u22124) and 1.27\u2009\u00d7\u200910\u22124 (95% HPD: 0.65\u20131.85\u2009\u00d7\u200910\u22124) subs\/site\/year. The SFTSV most likely originated from South Korea around the year of 1617.6 (95% HPD: 1513.1\u20131724.3), 1700.4 (95% HPD: 1493.7\u20131814.0), and 1790.1 (95% HPD: 1605.4\u20131887.2) for L, M, and S segments, respectively. Hubei Province in China played a critical role in the geographical expansion of the SFTSV. The effective population size of SFTSV peaked around 2010 to 2013. We also identified several codons under positive selection in the RdRp, Gn\u2013Gc, and NS genes. By leveraging the largest dataset of SFTSV, our analysis could provide new insights into the evolution and dispersal of SFTSV, which may be beneficial for the control and prevention of severe fever with thrombocytopenia syndrome.<\/jats:p>","DOI":"10.1093\/ve\/veae072","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:50:57Z","timestamp":1725601857000},"source":"Crossref","is-referenced-by-count":9,"title":["The classification, origin, and evolutionary dynamics of severe fever with thrombocytopenia syndrome virus circulating in East Asia"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-1096","authenticated-orcid":false,"given":"Shaowei","family":"Sang","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Unit, Qilu Hospital of Shandong University , No. 107 Wenhua Road, Lixia District, Jinan 250012, People\u2019s Republic of China"},{"name":"Clinical Research Center of Shandong University , No. 107 Wenhua Road, Lixia District, Jinan 250012, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Healthcare-associated Infection Management, School and Hospital of Stomatology, Shandong University , No. 44-1 Wenhua Road, Lixia District, Jinan 250012, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxi","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, Qilu Hospital of Shandong University , No. 107 Wenhua Road, Lixia District, Jinan 250012, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, Qilu Hospital of Shandong University , No. 107 Wenhua Road, Lixia District, Jinan 250012, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiguan","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences , No. 300 Fenglin Road, Xuhui District, Shanghai 200032, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Vector Surveillance and Management , No. 55 Changbai Road, Changping District, Beijing 102206, People\u2019s Republic of 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