{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:30:49Z","timestamp":1787506249966,"version":"build-2736575974"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To comprehend the time of emergence and extent of cryptic circulation for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Thailand, plasma specimens collected from patients at Siriraj Hospital, Bangkok, Thailand presenting with acute undifferentiated febrile illness (AUFI) were characterized by next-generation sequencing (NGS). Molecular and serological diagnostics were developed to screen for viral RNA and antibodies. Phylogenetic and phylogeographic analyses were performed using sequences generated from this study, publicly available genomes, and unsampled taxa to enhance temporal and geographic resolution. NGS detected SFTSV in 7 individuals with a median age of 73\u00a0years. Clinical manifestations ranged from low-grade fever and altered consciousness to multi-organ failure and death. RT-qPCR revealed three additional RNA positives, and antibody screening identified 38 IgG-positives for an incidence and prevalence of 0.4% and 2.7%, respectively. While SFTSV is reported as having been introduced into Thailand in 2019, evidence of infections dates back to 2012. Phylogenetic analyses revealed multiple introductions of Lineage 2 into Thailand around 2011\u201312, and phylogeographic reconstructions identified Thailand as a source for SFTSV spread to China and neighbouring countries. SFTSV has circulated cryptically in Thailand since 2012, diversifying locally and establishing endemicity. Genomic surveillance through improved diagnostics will be necessary to curb its spread through Asia and beyond.<\/jats:p>","DOI":"10.1093\/ve\/veaf078","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:52:03Z","timestamp":1758883923000},"source":"Crossref","is-referenced-by-count":1,"title":["Retrospective detection of severe fever with thrombocytopenia syndrome virus (SFTSV) revises timeline of emergence in Thailand"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-5181","authenticated-orcid":false,"given":"Lester J","family":"Perez","sequence":"first","affiliation":[{"name":"Infectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories , 100 Abbott Park Road, Abbott Park, IL 60064 ,","place":["USA"]},{"name":"Abbott Pandemic Defense Coalition (APDC) , 100 Abbott Park Road, Abbott Park, IL 60064 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Abbott Park, IL 60064 ,","place":["USA"]},{"name":"Faculty of Medicine Siriraj Hospital, Mahidol University , 2 Wang Lang Road, Bangkok 10700 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Weiss","sequence":"additional","affiliation":[{"name":"Infectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories , 100 Abbott Park Road, Abbott Park, IL 60064 ,","place":["USA"]},{"name":"Abbott Pandemic Defense Coalition (APDC) , 100 Abbott Park Road, Abbott Park, IL 60064 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Infectious Disease Research, Abbott Diagnostics Division, Abbott Laboratories , 100 Abbott Park Road, Abbott Park, IL 60064 ,","place":["USA"]},{"name":"Abbott Pandemic Defense Coalition (APDC) , 100 Abbott Park Road, Abbott Park, IL 60064 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