{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:11:49Z","timestamp":1791119509043,"version":"4.1.0"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While the genus Prasinovirus, known to infect prasinophyte green algae (class Mamiellophyceae), is abundant in the oceans, the genetic mechanisms governing the ecology and (co)evolution of these viruses remain poorly understood. In this study, we sequenced the complete genomes of eighteen viruses infecting the cosmopolitan unicellular green alga Ostreococcus tauri (OtVs) and one specific to Micromonas commoda (McV-20\u00a0T). Of these viruses, 12 were previously isolated from the coastal Mediterranean Sea and seven were newly isolated from two different geographical locations (i.e. the South Pacific Ocean and the North Sea). Phylogenetic analysis classified these viruses as new members of the Prasinovirus genus and defined three distinct OtV clades: designated OtV-type 1, OtV-type 2a, and OtV-type 2b. The OtV-type 1 includes three new viruses isolated from the Pacific Ocean and the previously sequenced genome OtV6. The OtV-type 1 form a large cluster within the Micromonas-infecting virus clade, sharing five unique homologous genes with all Micromonas viruses. In addition, genetic features of OtV-type 1, including a higher number of CDSs (~260) and lower Guanine-Cytosine content (GC) content (~41%), were more closely allied to Micromonas viruses than to those of OtVs, suggesting an alternative host or a recent host switch from Micromonas to O. tauri. By analysing the OtV genomes, we found a faster-evolving central hypervariable region (HVR), where the OtV-type 2b displayed the largest region, i.e. three times longer than other OtVs. This region encodes genes mainly associated with host cell recognition and attachment and under strong selective pressure (positive and negative). Notably, most viruses associated with OtV-type 2b showed the broadest host range. Infection dynamics between the hosts and the viruses appeared highly specific to host\u2013virus pairs, suggesting complex interactions in the Ostreococcus-prasinovirus system. Finally, by observing viral lysates with electron microscopy, we observed novel morphologies never described for these viruses. Overall, this study provides new insights into the genetic diversity of prasinoviruses and describes for the first time a viral plasticity that might be strongly shaped by antagonistic coevolution with their hosts.<\/jats:p>","DOI":"10.1093\/ve\/veaf096","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:10:42Z","timestamp":1769515842000},"source":"Crossref","is-referenced-by-count":4,"title":["Genomic analysis of\n                    <i>Ostreococcus tauri<\/i>\n                    -infecting viruses reveals a hypervariable region associated with host\u2013virus interactions"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-8874","authenticated-orcid":false,"given":"Julie","family":"Thomy","sequence":"first","affiliation":[{"name":"Integrative Biology of Marine Organisms (BIOM), UMR7232, Sorbonne University, CNRS, Oceanographic Observatory of Banyuls-sur-Mer , 20 Avenue Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]},{"name":"Daniel K. Inouye Center for Microbial Oceanography: Research and Education, School of Ocean and Earth Science and Technology (SOEST), University of Hawai`i at M\u0101noa , 1950 East-West Road, Honolulu, HI 96822 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-8881","authenticated-orcid":false,"given":"Julien","family":"Henri","sequence":"additional","affiliation":[{"name":"The Laboratory of Computational and Quantitative Biology (LCQB), Institute of Biology Paris-Seine, Sorbonne University , CNRS, 4 Place Jussieu, F-75005 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-8925","authenticated-orcid":false,"given":"David","family":"Demory","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Microbial Biotechnology (LBBM), Sorbonne University , CNRS, Oceanographic Observatory of Banyuls-sur-Mer, 20 Av. Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Integrative Biology of Marine Organisms (BIOM), UMR7232, Sorbonne University, CNRS, Oceanographic Observatory of Banyuls-sur-Mer , 20 Avenue Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Line","family":"Escande","sequence":"additional","affiliation":[{"name":"Integrative Biology of Marine Organisms (BIOM), UMR7232, Sorbonne University, CNRS, Oceanographic Observatory of Banyuls-sur-Mer , 20 Avenue Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Mirambeau","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Microbial Biotechnology (LBBM), Sorbonne University , CNRS, Oceanographic Observatory of Banyuls-sur-Mer, 20 Av. Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Grimsley","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Microbial Biotechnology (LBBM), Sorbonne University , CNRS, Oceanographic Observatory of Banyuls-sur-Mer, 20 Av. Pierre Fabre, F-66650 Banyuls-sur-Mer ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-132X","authenticated-orcid":false,"given":"Sheree","family":"Yau","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Microbial Biotechnology (LBBM), Sorbonne University , CNRS, Oceanographic Observatory of Banyuls-sur-Mer, 20 Av. 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