{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:09:22Z","timestamp":1791259762930,"version":"4.1.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":151,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Open Philanthropy"},{"DOI":"10.13039\/100020163","name":"Skoll Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020163","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MacKenzie Scott"},{"DOI":"10.13039\/501100009977","name":"ELMA Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TED\u2019s Audacious Project","award":["U01AI151812"],"award-info":[{"award-number":["U01AI151812"]}]},{"DOI":"10.13039\/100020166","name":"Flu Lab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"World Bank ACE-IMPACT","award":["U54HG007480"],"award-info":[{"award-number":["U54HG007480"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["#W81XWH-18-2-0040"],"award-info":[{"award-number":["#W81XWH-18-2-0040"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Emerging Infectious Diseases Branch"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lassa fever is a viral haemorrhagic fever that poses a persistent public health threat in several West African countries, particularly Nigeria. The scarcity of Lassa virus (LASV) sequences isolated from small mammal reservoirs limits our knowledge and understanding of LASV genomic diversity and transmission dynamics. To address this knowledge gap, we sampled 1189 small mammals, including mice, rats, and shrews, from two LASV-endemic states in southern Nigeria (Ondo and Ebonyi States) and tested them for the presence of LASV RNA using reverse transcription-quantitative polymerase chain reaction. Selected quantitative polymerase chain reaction-positive samples were subjected to whole genome sequencing and small mammal speciation through next-generation sequencing outputs. We recorded an overall polymerase chain reaction positivity rate of 61.6%, with rat species demonstrating the highest LASV prevalence. We also conducted a serosurvey of 269 small rodents using indirect Enzyme-Linked Immunosorbent Assay (ELISA) and obtained an overall anti-LASV seroprevalence of 45%. Using the Nextera XT metagenomic sequencing protocol, we produced 55 LASV partial (n\u2009=\u200928) and full-length genomes (n\u2009=\u200927) from small mammals sampled, all of which clustered within sublineage 2g. LASV sequences generated from this study suggest that LASV variation is mostly driven by location, as isolates from this study tend to cluster more closely with other isolates collected from within the same region, rather than by collection date or host. However, samples collected from Ebonyi State were more closely related to isolates collected in Ondo State than to isolates from Edo, despite a larger physical distance. Overall, the data from this study suggest free movement of the virus across states in Nigeria, among humans and various non-human taxa. The finding of LASV in additional small mammal hosts suggests that the virus reservoir is vast and may include many small mammals not well-characterized.<\/jats:p>","DOI":"10.1093\/ve\/veag032","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:24:04Z","timestamp":1780313044000},"source":"Crossref","is-referenced-by-count":1,"title":["Genomic epidemiology and evolutionary analysis of Lassa virus from small mammals suggest bidirectional viral movement across humans and animals"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-5175","authenticated-orcid":false,"given":"Anise N","family":"Happi","sequence":"first","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusola A","family":"Ogunsanya","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayotunde E","family":"Sijuwola","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femi M","family":"Saibu","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazeem","family":"Akano","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Natural Sciences, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akeemat O","family":"Ayinla","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O","family":"Daodu","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]},{"name":"Department of Biological Sciences, Faculty of Natural Sciences, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Page","sequence":"additional","affiliation":[{"name":"Department of immunology and Microbiology, The Scripps Research Institute , La Jolla, CA 92037 ,","place":["United States"]},{"name":"University of California, San Diego (UCSD) , La Jolla, CA 92093 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-153X","authenticated-orcid":false,"given":"Testimony J","family":"Olumade","sequence":"additional","affiliation":[{"name":"African Centre of Excellence for Genomics of Infectious Disease, Redeemer\u2019s University , P.M.B 230, Off Gbongan-Osogbo Road, Akoda-Ede, Osun State ,","place":["Nigeria"]},{"name":"Department of Biological Sciences, Faculty of Natural Sciences, Redeemer\u2019s 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