{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:51:56Z","timestamp":1792061516882,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Human adenoviruses (HAdVs) are a frequent cause of respiratory tract infections in children; however, their epidemiological patterns and genomic diversity remain insufficiently characterized in Europe. As respiratory HAdVs can cause outbreaks of acute and severe disease and show periodic re-emergence, improved understanding of their circulation is needed. Aim: To investigate the epidemiology, age distribution, and genomic diversity of respiratory HAdVs in paediatric patients in \u00cele-de-France during the first half of 2022. Methods: We retrospectively analysed 6\u2009956 respiratory samples from patients &amp;lt;\u200918\u00a0years, collected at five hospitals (Jan\u2013June 2022). HAdVs were detected by multiplex PCR. Viral loads were quantified in mono-infections, and whole-genome sequencing (WGS) was performed on samples with sufficient viral load. Results: HAdVs were detected in 14% of samples, making them the second most prevalent virus after rhinovirus\/enterovirus. Co-infections were frequent (64%), particularly in younger children. Among the 254 mono-infected samples with viral-load quantification, 110 (43%) had low or undetectable viral loads. WGS of 122 samples revealed HAdV species B (62.3%), C (34.4%), and F (3.3%). Species distribution varied by age: HAdV-C predominated in children under 2\u00a0years, while HAdV-B was more common in older children. The most frequent genotypes were B3 (76.3%), B66 (18.4%), and B7d (5.3%) within species B, and C1 (33.3%), C89 (26.2%), and C2 (23.8%) within species C. Conclusion: HAdVs are prevalent among children with respiratory infections, with age-specific patterns and substantial genomic diversity. The circulation of diverse genotypes, including recombinants and potentially more virulent variants, highlights the importance of sustained molecular surveillance.<\/jats:p>","DOI":"10.1093\/ve\/veag064","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:24:02Z","timestamp":1790335442000},"source":"Crossref","is-referenced-by-count":0,"title":["Molecular epidemiology of paediatric respiratory adenovirus infections in \u00cele-de-France: findings from whole-genome sequencing"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-6132","authenticated-orcid":false,"given":"Maud","family":"Salmona","sequence":"first","affiliation":[{"name":"Virology Department, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9 , 1 av Claude Vellefaux, 75010 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris Cit\u00e9, Biology and Pathogenesis of Viral Infection Team, INSERM UMR 1342, Saint-Louis Research Institute, 1 av Claude Vellefaux , 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Diaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris Cit\u00e9, Biology and Pathogenesis of Viral Infection Team, INSERM UMR 1342, Saint-Louis Research Institute, 1 av Claude Vellefaux , 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Feghoul","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9 , 1 av Claude Vellefaux, 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdeljalil","family":"Senhaji Rachik","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9 , 1 av Claude Vellefaux, 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"Delagr\u00e8verie","sequence":"additional","affiliation":[{"name":"Virology Unit, Department of Microbiology, H\u00f4pital Avicenne, AP-HP , Bobigny \u00a0","place":["France"]},{"name":"Universit\u00e9 Sorbonne Paris Nord and Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1137, IAME , 125 rue de Stalingrad, 93000 Bobigny,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honorine","family":"Fenaux","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Paul-Brousse, AP-HP , 2 avenue Paul-Vaillant-Couturier, 94800 Villejuif,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Schnuriger","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pitaux Saint-Antoine, Tenon, Trousseau, AP-HP, Sorbonne Universit\u00e9 , 184 rue du Faubourg Saint-Antoine, 75012 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Baron","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, H\u00f4pital Robert-Debr\u00e9, AP-HP , Universit\u00e9 Paris Cit\u00e9, 48 boulevard S\u00e9rurier, 75019 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Limam","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Paul-Brousse, AP-HP , 2 avenue Paul-Vaillant-Couturier, 94800 Villejuif,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Mercier-Delarue","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9 , 1 av Claude Vellefaux, 75010 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyanne","family":"Gault","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, H\u00f4pital Ambroise-Par\u00e9, AP-HP , 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"LeGoff","sequence":"additional","affiliation":[{"name":"Virology Department, H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris Cit\u00e9 , 1 av Claude Vellefaux, 75010 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Universit\u00e9 Paris Cit\u00e9, Biology and Pathogenesis of Viral Infection Team, INSERM UMR 1342, Saint-Louis Research Institute, 1 av Claude Vellefaux , 75010 Paris 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