{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:54:10Z","timestamp":1779342850912,"version":"3.51.4"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1998,5,15]],"date-time":"1998-05-15T00:00:00Z","timestamp":895190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1998,5,15]],"date-time":"1998-05-15T00:00:00Z","timestamp":895190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[1998,5,15]]},"DOI":"10.1093\/emboj\/17.10.2914","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:44:48Z","timestamp":1027709088000},"page":"2914-2925","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["A single amino acid substitution in yeast eIF\u20105A results in mRNA stabilization"],"prefix":"10.1038","volume":"17","author":[{"given":"Dorit","family":"Zuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1998,5,15]]},"reference":[{"key":"BFEMBJ7590999_CR1","first-page":"2932","volume":"6","author":"SA Adam","year":"1986","unstructured":"Adam SA, Nakagawa T, Swanson MS, Woodruff TK and Dreyfuss G (1986) mRNA polyadenylate\u2010binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. Mol Cell Biol, 6, 2932\u20132943.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW and Lipman DJ (1990) Basic local alignment search tool. J Mol Biol, 215, 403\u2013410.","journal-title":"J Mol Biol"},{"key":"BFEMBJ7590999_CR3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1091\/mbc.6.5.611","volume":"6","author":"AL Atkin","year":"1995","unstructured":"Atkin AL, Altamura N, Leeds P and Culbertson MR (1995) The majority of yeast UPF1 co\u2010localizes with polyribosomes in the cytoplasm. Mol Biol Cell, 6, 611\u2013625.","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7590999_CR4","doi-asserted-by":"crossref","first-page":"22163","DOI":"10.1074\/jbc.272.35.22163","volume":"272","author":"AL Atkin","year":"1997","unstructured":"Atkin AL, Schenkman LR, Eastham M, Dahlseid JN, Lelivelt MJ and Culbertson MR (1997) Relationship between yeast polyribosomes and upf proteins required for nonsense mRNA decay. J Biol Chem, 272, 22163\u201322172.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0076-6879(91)94015-5","volume":"194","author":"DM Becker","year":"1991","unstructured":"Becker DM and Guarente L (1991) High\u2010efficiency transformation of yeast by electroporation. Methods Enzymol, 194, 182\u2013187.","journal-title":"Methods Enzymol"},{"key":"BFEMBJ7590999_CR6","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1016\/S0021-9258(17)36937-5","volume":"269","author":"CA Beelman","year":"1994","unstructured":"Beelman CA and Parker R (1994) Differential effects of translational inhibition in cis and trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem, 269, 9687\u20139692.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR7","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/382642a0","volume":"382","author":"CA Beelman","year":"1996","unstructured":"Beelman CA, Stevens A, Caponigro G, LaGrandeur TE, Hatfield L and Parker R (1996) An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature, 382, 642\u2013646.","journal-title":"Nature"},{"key":"BFEMBJ7590999_CR8","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1016\/S0021-9258(17)40804-0","volume":"253","author":"R Benne","year":"1978","unstructured":"Benne R, Brown\u2010Luedi ML and Hershey JW (1978) Purification and characterization of protein synthesis initiation factors eIF\u20101, eIF\u20104C, eIF\u20104D, and eIF\u20105 from rabbit reticulocytes. J Biol Chem, 253, 3070\u20133077.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR9","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1126\/science.271.5257.1858","volume":"271","author":"D Bevec","year":"1996","unstructured":"Bevec D et al. (1996) Inhibition of HIV\u20101 replication in lymphocytes by mutants of the Rev cofactor eIF\u20105A. Science, 271, 1858\u20131860.","journal-title":"Science"},{"key":"BFEMBJ7590999_CR10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1074\/jbc.271.1.432","volume":"271","author":"R Boeck","year":"1996","unstructured":"Boeck R, Tarun S, Rieger M, Deardorff JA, M\u00fcller\u2010Auer S and Sachs AB (1996) The yeast Pan2 protein is required for poly(A)\u2010binding protein\u2010stimulated poly(A)\u2010nuclease activity. J Biol Chem, 271, 432\u2013438.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR11","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1128\/MCB.16.10.5744","volume":"16","author":"CE Brown","year":"1996","unstructured":"Brown CE, Tarun SZ, Boeck R and Sachs AB (1996) PAN3 encodes a subunit of the Pab1p\u2010dependent poly(A) nuclease in Saccharomyces cerevisiae. Mol Cell Biol, 16, 5744\u20135753.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/mr.60.1.233-249.1996","volume":"60","author":"G Caponigro","year":"1996","unstructured":"Caponigro G and Parker R (1996) Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev, 60, 233\u2013249.","journal-title":"Microbiol Rev"},{"key":"BFEMBJ7590999_CR13","first-page":"5141","volume":"13","author":"G Caponigro","year":"1993","unstructured":"Caponigro G, Muhlrad D and Parker R (1993) A small segment of the MAT\u03b11 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol, 13, 5141\u20135148.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR14","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1016\/S0021-9258(18)31768-X","volume":"269","author":"N Caruccio","year":"1994","unstructured":"Caruccio N and Ross J (1994) Purification of a human polyribosome\u2010associated 3\u2032 to 5\u2032 exoribonuclease. J Biol Chem, 269, 3184\u201331821.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR15","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1002\/j.1460-2075.1994.tb06817.x","volume":"13","author":"RE Chapman","year":"1994","unstructured":"Chapman RE and Munro S (1994) The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. EMBO J, 13, 4896\u20134907.","journal-title":"EMBO J"},{"key":"BFEMBJ7590999_CR16","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1073\/pnas.80.7.1854","volume":"80","author":"HL Cooper","year":"1983","unstructured":"Cooper HL, Park MH, Folk JE, Safer B and Braverman R (1983) Identification of the hypusine\u2010containing protein hy+ as translation initiation factor eIF\u20104D. Proc Natl Acad Sci USA, 80, 1854\u20131857.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7590999_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1101\/gad.9.4.423","volume":"9","author":"Y Cui","year":"1995","unstructured":"Cui Y, Hagan KW, Zhang S and Peltz SW (1995) Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev, 9, 423\u2013436.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR18","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1002\/j.1460-2075.1996.tb00956.x","volume":"15","author":"Y Cui","year":"1996","unstructured":"Cui Y, Dinman JD and Peltz SW (1996) Mof4\u20101 is an allele of the UPF1\/IFS2 gene which affects both mRNA turnover and \u22121 ribosomal frameshifting efficiency. EMBO J, 15, 5726\u20135736.","journal-title":"EMBO J"},{"key":"BFEMBJ7590999_CR19","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1101\/gad.7.8.1632","volume":"7","author":"CJ Decker","year":"1993","unstructured":"Decker CJ and Parker R (1993) A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev, 7, 1632\u20131643.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0968-0004(94)90073-6","volume":"19","author":"CJ Decker","year":"1994","unstructured":"Decker CJ and Parker R (1994) Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci, 19, 336\u2013340.","journal-title":"Trends Biochem Sci"},{"key":"BFEMBJ7590999_CR21","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1074\/jbc.272.20.13372","volume":"16","author":"FA Dick","year":"1997","unstructured":"Dick FA, Karamanou S and Trumpower BL (1997) QSR1, an essential yeast gene with a genetic relationship to a subunit of the mitochondrial cytochrome bc1 complex, codes for a 60S ribosomal subunit protein. J Biol Chem, 16, 13372\u201313379.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","volume":"132","author":"AP Feinberg","year":"1983","unstructured":"Feinberg AP and Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem, 132, 6\u201313 (addendum 1984 Anal Biochem, 137, 266\u2013267).","journal-title":"Anal Biochem"},{"key":"BFEMBJ7590999_CR23","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1002\/j.1460-2075.1994.tb06728.x","volume":"13","author":"U Fischer","year":"1994","unstructured":"Fischer U, Meyer S, Teufel M, Heckel C, Luhrmann R and Rautmann G (1994) Evidence that HIV\u20101 Rev directly promotes the nuclear export of unspliced RNA. EMBO J, 13, 4105\u20134112.","journal-title":"EMBO J"},{"key":"BFEMBJ7590999_CR24","doi-asserted-by":"crossref","first-page":"16585","DOI":"10.1016\/S0021-9258(18)49296-4","volume":"262","author":"ED Gordon","year":"1987","unstructured":"Gordon ED, Mora R, Meredith SC, Lee C and Lindquist SL (1987) Eukaryotic initiation factor 4D, the hypusine\u2010containing protein, is conserved among eukaryotes. J Biol Chem, 262, 16585\u201316589.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1128\/MCB.15.2.809","volume":"15","author":"KW Hagan","year":"1995","unstructured":"Hagan KW, Ruiz\u2010Echevarria MJ, Quan Y and Peltz SW (1995) Characterization of cis\u2010acting sequences and decay intermediates involved in nonsense\u2010mediated mRNA turnover. Mol Cell Biol, 15, 809\u2013823.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR26","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1128\/MCB.16.10.5830","volume":"16","author":"L Hatfield","year":"1996","unstructured":"Hatfield L, Beelman CA, Stevens A and Parker R (1996) Mutations in trans\u2010acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol, 16, 5830\u20135838.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1101\/gad.9.4.437","volume":"9","author":"F He","year":"1995","unstructured":"He F and Jacobson A (1995) Identification of a novel component of the nonsense\u2010mediated mRNA decay pathway using an interacting protein screen. Genes Dev, 9, 437\u2013454.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR28","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1073\/pnas.90.15.7034","volume":"90","author":"F He","year":"1993","unstructured":"He F, Peltz SW, Donahue JL, Rosbash M and Jacobson A (1993) Stabilization and ribosome association of unspliced pre\u2010mRNAs in a yeast upf1\u2212 mutant. Proc Natl Acad Sci USA, 90, 7034\u20137038.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7590999_CR29","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1128\/MCB.17.3.1580","volume":"17","author":"F He","year":"1997","unstructured":"He F, Brown AH and Jacobson A (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense\u2010mediated mRNA decay pathway. Mol Cell Biol, 17, 1580\u20131594.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR30","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1128\/MCB.16.7.3833","volume":"16","author":"AN Hennigan","year":"1996","unstructured":"Hennigan AN and Jacobson A (1996) Functional mapping of the translation\u2010dependent instability element of yeast MATa1 mRNA. Mol Cell Biol, 16, 3833\u20133843.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR31","first-page":"2269","volume":"10","author":"D Herrick","year":"1990","unstructured":"Herrick D, Parker R and Jacobson A (1990) Identification and comparison of stable and unstable mRNAs in the yeast Saccharomyces cerevisiae. Mol Cell Biol, 10, 2269\u20132284.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.122.3.635","volume":"122","author":"DA Holtzman","year":"1993","unstructured":"Holtzman DA, Yang S and Drubin DG (1993) Synthetic\u2010lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol, 122, 635\u2013644.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7590999_CR33","first-page":"4826","volume":"13","author":"CL Hsu","year":"1993","unstructured":"Hsu CL and Stevens A (1993) Yeast cells lacking 5\u2032\u21923\u2032 exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5\u2032 cap structure. Mol Cell Biol, 13, 4826\u20134835.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR34","first-page":"451","volume-title":"Translational Control","author":"A Jacobson","year":"1996","unstructured":"Jacobson A (1996) Poly(A) metabolism and translation: the closed loop model. In Hershey,J., Mathews,M. and Sonenberg,N. (eds), Translational Control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 451\u2013480."},{"key":"BFEMBJ7590999_CR35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.bi.65.070196.003401","volume":"65","author":"A Jacobson","year":"1996","unstructured":"Jacobson A and Peltz SW (1996) Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem, 65, 693\u2013740.","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ7590999_CR36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/AAC.3.6.729","volume":"3","author":"A Jimenez","year":"1973","unstructured":"Jimenez A, Tipper DJ and Davies J (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob Agents Chemother, 3, 729\u2013738.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ7590999_CR37","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1016\/S0021-9258(17)41723-6","volume":"269","author":"HA Kang","year":"1994","unstructured":"Kang HA and Hershey JW (1994) Effect of initiation factor eIF\u20105A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae. J Biol Chem, 269, 3934\u20133940.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR38","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1016\/S0021-9258(17)33095-8","volume":"251","author":"WM Kemper","year":"1976","unstructured":"Kemper WM, Berry KW and Merrick WC (1976) Purification and properties of rabbit reticulocyte protein synthesis initiation factors M2B\u03b1 and M2B\u03b2. J Biol Chem, 251, 5551\u20135557.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0022-2836(90)90154-E","volume":"214","author":"DG Kneller","year":"1990","unstructured":"Kneller DG, Cohen FE and Langridge R (1990) Improvements in protein secondary structure prediction by an enhanced neural network. J Mol Biol, 214, 171\u2013182.","journal-title":"J Mol Biol"},{"key":"BFEMBJ7590999_CR40","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1126\/science.2672333","volume":"245","author":"V Kruys","year":"1989","unstructured":"Kruys V, Marinx O, Shaw G, Deschamps J and Huez G (1989) Translational blockade imposed by cytokine\u2010derived UA\u2010rich sequences. Science, 245, 852\u2013855.","journal-title":"Science"},{"key":"BFEMBJ7590999_CR41","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/emboj\/17.5.1487","volume":"17","author":"TE La Grandeur","year":"1998","unstructured":"La Grandeur TE and Parker R (1998) Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J, 17, 1487\u20131496.","journal-title":"EMBO J"},{"key":"BFEMBJ7590999_CR42","doi-asserted-by":"crossref","first-page":"10354","DOI":"10.1073\/pnas.92.22.10354","volume":"92","author":"BS Lee","year":"1995","unstructured":"Lee BS and Culbertson MR (1995) Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc Natl Acad Sci USA, 92, 10354\u201310358.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7590999_CR43","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1073\/pnas.92.14.6587","volume":"92","author":"SI Lee","year":"1995","unstructured":"Lee SI, Umen JG and Varmus HE (1995) A genetic screen identifies cellular factors involved in retroviral \u22121 frameshifting. Proc Natl Acad Sci USA, 92, 6587\u20136591.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7590999_CR44","first-page":"2165","volume":"12","author":"P Leeds","year":"1992","unstructured":"Leeds P, Wood JM, Lee B\u2010S and Culbertson MR (1992) Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol, 12, 2165\u20132177.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1128\/MCB.18.2.665","volume":"18","author":"HJ Lo","year":"1998","unstructured":"Lo HJ, Huang HK and Donahue TF (1998) RNA polymerase I\u2010promoted HIS4 expression yields uncapped, polyadenylated mRNA that is unstable and inefficiently translated in Saccharomyces cerevisiae. Mol Cell Biol, 18, 665\u2013675.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR46","first-page":"6180","volume":"13","author":"MH Malim","year":"1993","unstructured":"Malim MH and Cullen BR (1993) Rev and the fate of pre\u2010mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. Mol Cell Biol, 13, 6180\u20136189.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0012-1606(86)90058-8","volume":"116","author":"RE Manrow","year":"1986","unstructured":"Manrow RE and Jacobson A (1986) Identification and characterization of developmentally regulated mRNP proteins of Dictyostelium discoideum. Dev Biol, 116, 213\u2013227.","journal-title":"Dev Biol"},{"key":"BFEMBJ7590999_CR48","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-5793(94)00413-7","volume":"345","author":"O Marinx","year":"1994","unstructured":"Marinx O, Bertrand S, Karsenti E, Huez G and Kruys V (1994) Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3\u2032UUAUUUAU elements. FEBS Lett, 345, 107\u2013112.","journal-title":"FEBS Lett"},{"key":"BFEMBJ7590999_CR49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00332681","volume":"188","author":"RD Miller","year":"1982","unstructured":"Miller RD, Prakash L and Prakash S (1982) Defective excision of pyrimidine dimers and interstrand DNA crosslinks in rad7 and rad23 mutants of Saccharomyces cerevisiae. Mol Gen Genet, 188, 235\u2013239.","journal-title":"Mol Gen Genet"},{"key":"BFEMBJ7590999_CR50","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/370578a0","volume":"370","author":"D Muhlrad","year":"1994","unstructured":"Muhlrad D and Parker R (1994) Premature translational termination triggers mRNA decapping. Nature, 370, 578\u2013581.","journal-title":"Nature"},{"key":"BFEMBJ7590999_CR51","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1101\/gad.8.7.855","volume":"8","author":"D Muhlrad","year":"1994","unstructured":"Muhlrad D, Decker CJ and Parker R (1994) Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5\u2032\u21923\u2032 digestion of the transcript. Genes Dev, 8, 855\u2013866.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR52","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/MCB.15.4.2145","volume":"15","author":"D Muhlrad","year":"1995","unstructured":"Muhlrad D, Decker CJ and Parker R (1995) Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol, 15, 2145\u20132156.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR53","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1021\/bi00541a018","volume":"21","author":"TW Munns","year":"1982","unstructured":"Munns TW, Liszewski MK, Tellam JT, Sims HF and Rhoads RE (1982) Antibody\u2013nucleic acid complexes. Immunospecific retention of globin messenger ribonucleic acid with antibodies specific for 7\u2010methyl guanosine. Biochemistry, 21, 2922\u20132928.","journal-title":"Biochemistry"},{"key":"BFEMBJ7590999_CR54","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1074\/jbc.270.12.6815","volume":"270","author":"S Na","year":"1995","unstructured":"Na S, Hincapie M, McCusker JH and Haber JE (1995) MOP2 (SLA2) affects the abundance of the plasma membrane H(+)\u2010ATPase of Saccharomyces cerevisiae. J Biol Chem, 270, 6815\u20136823.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7590999_CR55","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/(SICI)1097-0061(19970930)13:12<1155::AID-YEA166>3.0.CO;2-O","volume":"13","author":"J Nika","year":"1997","unstructured":"Nika J, Erickson FL and Hannig EM (1997) Ribosomal protein L9 is the product of GRC5, a homolog of the putative tumor suppressor QM in S.cerevisiae. Yeast, 13, 1155\u20131166.","journal-title":"Yeast"},{"key":"BFEMBJ7590999_CR56","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1073\/pnas.87.7.2780","volume":"87","author":"R Parker","year":"1990","unstructured":"Parker R and Jacobson A (1990) Translation and a forty\u2010two nucleotide segment within the coding region of the mRNA encoded by the MATa1 gene are involved in promoting rapid mRNA decay in yeast. Proc Natl Acad Sci USA, 87, 2780\u20132784.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7590999_CR57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0076-6879(91)94032-8","volume":"194","author":"R Parker","year":"1991","unstructured":"Parker R, Herrick D, Peltz SW and Jacobson A (1991) Measurement of mRNA decay rates in Saccharomyces cerevisiae. Methods Enzymol, 194, 415\u2013423.","journal-title":"Methods Enzymol"},{"key":"BFEMBJ7590999_CR58","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1093\/nar\/13.17.6171","volume":"13","author":"LK Pape","year":"1985","unstructured":"Pape LK and Tzagoloff A (1985) Cloning and characterization of the gene for the yeast cytoplasmic threonyl\u2010tRNA synthetase. Nucleic Acids Res, 13, 6171\u20136183.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7590999_CR59","first-page":"5778","volume":"12","author":"SW Peltz","year":"1992","unstructured":"Peltz SW, Donahue JL and Jacobson A (1992) A mutation in tRNA nucleotidyltransferase stabilizes mRNAs in Saccharomyces cerevisiae. Mol Cell Biol, 12, 5778\u20135784.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR60","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1101\/gad.7.9.1737","volume":"7","author":"SW Peltz","year":"1993","unstructured":"Peltz SW, Brown AH and Jacobson A (1993a) mRNA destabilization triggered by premature translational termination depends on three mRNA sequence elements and at least one trans\u2010acting factor. Genes Dev, 7, 1737\u20131754.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR61","first-page":"1","volume-title":"Protein Synthesis and Targeting in Yeast","author":"SW Peltz","year":"1993","unstructured":"Peltz SW, Trotta C, Feng H, Brown AH, Donahue JL and Jacobson A (1993b) Identification of the cis\u2010acting and trans\u2010acting factors involved in nonsense\u2010mediated mRNA decay. In Brown,A., Tuite,M. and McCarthy,J. (eds), Protein Synthesis and Targeting in Yeast. Springer\u2010Verlag, Heidelberg, Germany, pp. 1\u201310."},{"key":"BFEMBJ7590999_CR62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0079-6603(08)60254-8","volume":"47","author":"SW Peltz","year":"1994","unstructured":"Peltz SW, He F, Welch E and Jacobson A (1994) Nonsense\u2010mediated mRNA decay in yeast. Prog Nucleic Acid Res Mol Biol, 47, 271\u2013297.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"BFEMBJ7590999_CR63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1083\/jcb.120.1.55","volume":"120","author":"S Raths","year":"1993","unstructured":"Raths S, Rohrer J, Crausaz F and Riezman H (1993) end3 and end4: two mutants defective in receptor\u2010mediated and fluid\u2010phase endocytosis in Saccharomyces cerevisiae. J Cell Biol, 120, 55\u201365.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7590999_CR64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0378-1119(87)90232-0","volume":"60","author":"MD Rose","year":"1987","unstructured":"Rose MD, Novick P, Thomas JH, Botstein D and Fink GR (1987) A Saccharomyces cerevisiae genomic plasmid bank based on centromere containing shuttle vector. Gene, 60, 237\u2013243.","journal-title":"Gene"},{"key":"BFEMBJ7590999_CR65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0168-9525(91)90276-V","volume":"7","author":"S Ruby","year":"1991","unstructured":"Ruby S and Abelson J (1991) Pre\u2010mRNA splicing in yeast. Trends Genet, 7, 79\u201385.","journal-title":"Trends Genet"},{"key":"BFEMBJ7590999_CR66","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1083\/jcb.123.6.1309","volume":"123","author":"M Ruhl","year":"1993","unstructured":"Ruhl M et al. (1993) Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans\u2010activation. J Cell Biol, 123, 1309\u20131320.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7590999_CR67","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(86)90557-X","volume":"45","author":"AB Sachs","year":"1986","unstructured":"Sachs AB, Bond MW and Kornberg RD (1986) A single gene from yeast for both nuclear and cytoplasmic polyadenylate\u2010binding proteins: domain structure and expression. Cell, 45, 827\u2013835.","journal-title":"Cell"},{"key":"BFEMBJ7590999_CR68","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0092-8674(00)80268-8","volume":"89","author":"AB Sachs","year":"1997","unstructured":"Sachs AB, Sarnow P and Hentze MW (1997) Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell, 89, 831\u2013838.","journal-title":"Cell"},{"key":"BFEMBJ7590999_CR69","volume-title":"Molecular Cloning: A Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"BFEMBJ7590999_CR70","first-page":"3105","volume":"11","author":"J Schnier","year":"1991","unstructured":"Schnier J, Schwelberger HG, Smit\u2010McBride Z, Kang HA and Hershey JW (1991) Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast S.cerevisiae. Mol Cell Biol, 11, 3105\u20133114.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR71","volume-title":"Methods in Yeast Genetics","author":"F Sherman","year":"1986","unstructured":"Sherman F, Fink GR and Hicks JB (1986) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"BFEMBJ7590999_CR72","first-page":"348","volume":"15","author":"XP Shi","year":"1996","unstructured":"Shi XP, Yin KC, Zimolo ZA, Stern AM and Waxman L (1996) The subcellular distribution of eukaryotic translation initiation factor, eIF\u20105A, in cultured cells. Exp Cell Res, 15, 348\u2013356.","journal-title":"Exp Cell Res"},{"key":"BFEMBJ7590999_CR73","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000109120","volume":"6","author":"XP Shi","year":"1997","unstructured":"Shi XP, Yin KC and Waxman L (1997) Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eIF\u20105A, and the HIV\u20101 Rev protein. Biol Signals, 6, 143\u2013149.","journal-title":"Biol Signals"},{"key":"BFEMBJ7590999_CR74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","volume":"122","author":"RS Sikorski","year":"1989","unstructured":"Sikorski RS and Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics, 122, 19\u201327.","journal-title":"Genetics"},{"key":"BFEMBJ7590999_CR75","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/BF00351857","volume":"24","author":"R Soni","year":"1993","unstructured":"Soni R, Carmichael JP and Murray JA (1993) Parameters affecting lithium acetate\u2010mediated transformation of Saccharomyces cerevisiae and development of a rapid and simplified procedure. Curr Genet, 24, 455\u2013459.","journal-title":"Curr Genet"},{"key":"BFEMBJ7590999_CR76","first-page":"2005","volume":"8","author":"A Stevens","year":"1988","unstructured":"Stevens A (1988) mRNA decapping enzyme from Saccharomyces cerevisiae: purification and unique specificity for long RNA chains. Mol Cell Biol, 8, 2005\u20132010.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR77","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1101\/gad.3.8.1206","volume":"3","author":"U Vijayraghavan","year":"1989","unstructured":"Vijayraghavan U, Company M and Abelson J (1989) Isolation and characterization of pre\u2010mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev, 3, 1206\u20131216.","journal-title":"Genes Dev"},{"key":"BFEMBJ7590999_CR78","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1128\/MCB.16.10.5491","volume":"16","author":"Y Weng","year":"1996","unstructured":"Weng Y, Czaplinski K and Peltz SW (1996) Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol Cell Biol, 16, 5491\u20135506.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7590999_CR79","first-page":"234","volume":"3","author":"S Zhang","year":"1997","unstructured":"Zhang S, Welch EM, Hagan K, Brown AH, Peltz SW and Jacobson A (1997) Polysome\u2010associated mRNAs are substrates for the nonsense\u2010mediated mRNA decay pathway in Saccharomyces cerevisiae. RNA, 3, 234\u2013244.","journal-title":"RNA"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F17.10.2914","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.10.2914.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/17.10.2914\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/17.10.2914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.10.2914.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:54:29Z","timestamp":1779299669000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/17.10.2914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,15]]},"references-count":79,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,5,15]]}},"alternative-id":["BFEMBJ7590999"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/17.10.2914","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5,15]]},"assertion":[{"value":"3 November 1997","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 1998","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 1998","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 1998","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}