{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:44:22Z","timestamp":1779345862993,"version":"3.51.4"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[1998,8,17]],"date-time":"1998-08-17T00:00:00Z","timestamp":903312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1998,8,17]],"date-time":"1998-08-17T00:00:00Z","timestamp":903312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[1998,8,17]]},"DOI":"10.1093\/emboj\/17.16.4626","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:44:48Z","timestamp":1027709088000},"page":"4626-4638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":275,"title":["Cholesterol\u2010dependent retention of GPI\u2010anchored proteins in endosomes"],"prefix":"10.1038","volume":"17","author":[{"given":"Satyajit","family":"Mayor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shefali","family":"Sabharanjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Maxfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1998,8,17]]},"reference":[{"key":"BFEMBJ7591159_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0962-8924(93)90065-9","volume":"3","author":"RGW Anderson","year":"1993","unstructured":"Anderson RGW (1993) Potocytosis of small molecules and ions by caveolae. Trends Cell Biol, 3, 69\u201372.","journal-title":"Trends Cell Biol"},{"key":"BFEMBJ7591159_CR2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/glia.440130205","volume":"13","author":"DN Angelov","year":"1995","unstructured":"Angelov DN, Gunkel A, Stennert E and Neiss WF (1995) Phagocytic microglia during delayed neuronal loss in the facial nucleus of the rat: time course of the neuronofugal migration of brain macrophages. Glia, 13, 113\u2013129.","journal-title":"Glia"},{"key":"BFEMBJ7591159_CR3","doi-asserted-by":"crossref","first-page":"C302","DOI":"10.1152\/ajpcell.1993.264.2.C302","volume":"264","author":"H Birn","year":"1993","unstructured":"Birn H, Selhub J and Christensen EI (1993) Cell fractionation and electron microscope studies of kidney folate\u2010binding protein. Am J Physiol, 264, C302\u2013C310.","journal-title":"Am J Physiol"},{"key":"BFEMBJ7591159_CR4","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1016\/S0021-9258(18)41985-0","volume":"267","author":"DR Borchelt","year":"1992","unstructured":"Borchelt DR, Taraboulos A and Prusiner SB (1992) Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem, 267, 16188\u201316199.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591159_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0952-7915(93)90052-T","volume":"5","author":"D Brown","year":"1993","unstructured":"Brown D (1993) The tyrosine kinase connection: how GPI\u2010anchored proteins activate T cells. Curr Opin Immunol, 5, 349\u2013354.","journal-title":"Curr Opin Immunol"},{"key":"BFEMBJ7591159_CR6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1083\/jcb.118.1.63","volume":"118","author":"W\u2010J Chang","year":"1992","unstructured":"Chang W\u2010J, Rothberg KG, Kamen BA and Anderson RGW (1992) Lowering cholesterol content of MA104 cells inhibits receptor\u2010mediated transport of folate. J Cell Biol, 118, 63\u201369.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR7","first-page":"6125","volume":"51","author":"LR Coney","year":"1991","unstructured":"Coney LR, Tomassetti A, Carayannopoulos L, Frasca V, Kamen BA, Colnaghi MI and Zurawski VJ (1991) Cloning of a tumor\u2010associated antigen: MOv18 and MOv19 antibodies recognize a folate\u2010binding protein. Cancer Res, 51, 6125\u20136132.","journal-title":"Cancer Res"},{"key":"BFEMBJ7591159_CR8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1084\/jem.163.5.1150","volume":"163","author":"MA Davitz","year":"1986","unstructured":"Davitz MA, Low MG and Nussenzweig V (1986) Release of decay\u2010accelerating factor (DAF) from the cell membrane by phosphatidylinositol\u2010specific phospholipase C (PIPLC): selective modification of a complement regulatory protein. J Exp Med, 163, 1150\u20131161.","journal-title":"J Exp Med"},{"key":"BFEMBJ7591159_CR9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1083\/jcb.117.2.301","volume":"117","author":"KW Dunn","year":"1992","unstructured":"Dunn KW and Maxfield FR (1992) Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes. J Cell Biol, 117, 301\u2013310.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR10","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1083\/jcb.109.6.3303","volume":"109","author":"KW Dunn","year":"1989","unstructured":"Dunn KW, McGraw TE and Maxfield FR (1989) Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome. J Cell Biol, 109, 3303\u20133314.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR11","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/j.1460-2075.1993.tb05804.x","volume":"12","author":"P Dupree","year":"1993","unstructured":"Dupree P, Parton RG, Raposo G, Kurzchalia TV and Simons K (1993) Caveolae and sorting in the trans\u2010Golgi network of epithelial cells. EMBO J, 12, 1597\u20131605.","journal-title":"EMBO J"},{"key":"BFEMBJ7591159_CR12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0169-4758(94)90392-1","volume":"10","author":"MAJ Ferguson","year":"1994","unstructured":"Ferguson MAJ (1994) What can GPI do for you. Parasitol Today, 10, 48\u201352.","journal-title":"Parasitol Today"},{"key":"BFEMBJ7591159_CR13","first-page":"83","volume-title":"Lipid Modification of Proteins","author":"MC Field","year":"1992","unstructured":"Field MC and Menon AK (1992) Glycolipid\u2010anchoring of cell surface proteins. In Schlesinger,M.J. (ed.), Lipid Modification of Proteins. CRC Press, Boca Raton, FL, pp. 83\u2013134."},{"key":"BFEMBJ7591159_CR14","doi-asserted-by":"crossref","unstructured":"Friedrichson T and Kurzchalia TV (1998) Microdomains of GPI\u2010anchored proteins in living cells revealed by chemical cross\u2010linking. Nature, in press.","DOI":"10.1038\/29570"},{"key":"BFEMBJ7591159_CR15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1177\/44.8.8756764","volume":"44","author":"T Fujimoto","year":"1996","unstructured":"Fujimoto T (1996) GPI\u2010anchored proteins, glycosphingolipids and sphingomyelin are sequestered to caveolae only after crosslinking. J Histochem Cytochem, 44, 929\u2013941.","journal-title":"J Histochem Cytochem"},{"key":"BFEMBJ7591159_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-77095-1","volume-title":"Fine structure immunochemistry","author":"G Griffiths","year":"1993","unstructured":"Griffiths G (1993) Fine structure immunochemistry. Springer\u2010Verlag, Heidelberg, Germany, pp. 1\u2013159."},{"key":"BFEMBJ7591159_CR17","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0955-0674(95)80013-1","volume":"7","author":"J Gruenberg","year":"1995","unstructured":"Gruenberg J and Maxfield FR (1995) Membrane transport in the endocytic pathway. Curr Opin Cell Biol, 7, 552\u2013563.","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ7591159_CR18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0955-0674(97)80030-0","volume":"9","author":"T Harder","year":"1997","unstructured":"Harder T and Simons K (1997) Caveolae, DIGs and the dynamics of sphingolipid\u2010cholesterol microdomains. Curr Opin Cell Biol, 9, 534\u2013542.","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ7591159_CR19","doi-asserted-by":"crossref","first-page":"C338","DOI":"10.1152\/ajpcell.1991.260.2.C338","volume":"260","author":"JT Hjelle","year":"1991","unstructured":"Hjelle JT, Christensen EI, Carone FA and Selhub J (1991) Cell fractionation and electron microscope studies of kidney folate\u2010binding protein. Am J Physiol, 260, C338\u2013C346.","journal-title":"Am J Physiol"},{"key":"BFEMBJ7591159_CR20","volume-title":"Antibodies: A Laboratory Manual","author":"E Howard","year":"1988","unstructured":"Howard E and Lane D (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"BFEMBJ7591159_CR21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1091\/mbc.4.12.1251","volume":"4","author":"LS Johnson","year":"1993","unstructured":"Johnson LS, Dunn KW, Pytowski B and McGraw TE (1993) Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif. Mol Biol Cell, 4, 1251\u20131266.","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7591159_CR22","doi-asserted-by":"crossref","first-page":"13602","DOI":"10.1016\/S0021-9258(18)68284-5","volume":"263","author":"BA Kamen","year":"1988","unstructured":"Kamen BA, Wang MT, Streckfuss AJ, Peryea X and Anderson RG (1988) Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem, 263, 13602\u201313609.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591159_CR23","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI114310","volume":"84","author":"BA Kamen","year":"1989","unstructured":"Kamen BA, Johnson CA, Wang MT and Anderson RG (1989) Regulation of the cytoplasmic accumulation of 5\u2010methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation. J Clin Invest, 84, 1379\u20131386.","journal-title":"J Clin Invest"},{"key":"BFEMBJ7591159_CR24","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1083\/jcb.140.6.1357","volume":"140","author":"P Keller","year":"1998","unstructured":"Keller P and Simons K (1998) Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol, 140, 1357\u20131367.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/j.1460-2075.1992.tb05124.x","volume":"11","author":"G\u2010A Keller","year":"1991","unstructured":"Keller G\u2010A, Siegel MW and Caras IW (1991) Endocytosis of glycophospholipid\u2010anchored and transmembrane forms of CD4 by different endocytic pathways. EMBO J, 11, 863\u2013874.","journal-title":"EMBO J"},{"key":"BFEMBJ7591159_CR26","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1083\/jcb.108.6.2169","volume":"108","author":"M Koval","year":"1989","unstructured":"Koval M and Pagano RE (1989) Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts. J Cell Biol, 108, 2169\u20132181.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR27","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0955-0674(95)80015-8","volume":"7","author":"C Lamaze","year":"1995","unstructured":"Lamaze C and Schmid SL (1995) The emergence of clathrin\u2010independent pinocytic pathways. Curr Opin Cell Biol, 7, 573\u2013580.","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ7591159_CR28","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1073\/pnas.87.19.7419","volume":"87","author":"MP Lisanti","year":"1990","unstructured":"Lisanti MP, Caras IW, Gilbert T, Hanzel D and Rodriguez BE (1990) Vectorial apical delivery and slow endocytosis of a glycolipid\u2010anchored fusion protein in transfected MDCK cells. Proc Natl Acad Sci USA, 87, 7419\u20137423.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591159_CR29","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1083\/jcb.129.6.1509","volume":"129","author":"EW Marsh","year":"1995","unstructured":"Marsh EW, Leopold PL, Jones NL and Maxfield FR (1995) Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long\u2010lived endocytic recycling compartment. J Cell Biol, 129, 1509\u20131522.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR30","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1091\/mbc.6.7.929","volume":"6","author":"S Mayor","year":"1995","unstructured":"Mayor S and Maxfield FR (1995) Insolubility and redistribution of GPI\u2010anchored proteins at the cell surface after detergent treatment. Mol Biol Cell, 6, 929\u2013944.","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ7591159_CR31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1083\/jcb.121.6.1257","volume":"121","author":"S Mayor","year":"1993","unstructured":"Mayor S, Presley JP and Maxfield FR (1993) Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. J Cell Biol, 121, 1257\u20131269.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR32","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1126\/science.7516582","volume":"264","author":"S Mayor","year":"1994","unstructured":"Mayor S, Rothberg KG and Maxfield FR (1994) Sequestration of GPI\u2010anchored proteins in caveolae triggered by cross\u2010linking. Science, 264, 1948\u20131951.","journal-title":"Science"},{"key":"BFEMBJ7591159_CR33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.130.5.1105","volume":"130","author":"RW Mays","year":"1995","unstructured":"Mays RW, Siemers KA, Fritz BA, Lowe AW, van Meer G and Nelson WJ (1995) Hierarchy of mechanisms involved in generating Na\/K\u2010ATPase polarity in MDCK epithelial cells. J Cell Biol, 130, 1105\u20131115.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR34","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1021\/bi00237a006","volume":"30","author":"TP McAlinden","year":"1991","unstructured":"McAlinden TP, Hynes JB, Patil SA, Westerhof GR, Jansen G, Schornagel JH, Kerwar SS and Freisheim JH (1991) Synthesis and biological evaluation of a fluorescent analogue of folic acid. Biochemistry, 30, 5674\u20135681.","journal-title":"Biochemistry"},{"key":"BFEMBJ7591159_CR35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/bj2940305","volume":"294","author":"MJ McConville","year":"1993","unstructured":"McConville MJ and Ferguson MA (1993) The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem J, 294, 305\u2013324.","journal-title":"Biochem J"},{"key":"BFEMBJ7591159_CR36","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1083\/jcb.112.5.853","volume":"112","author":"TE McGraw","year":"1991","unstructured":"McGraw TE, Pytowski B, Arzt J and Ferrone C (1991) Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second\u2010site mutation is capable of reverting an internalization\u2010defective phenotype. J Cell Biol, 112, 853\u2013861.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1152\/physrev.1997.77.3.759","volume":"77","author":"S Mukherjee","year":"1997","unstructured":"Mukherjee S, Ghosh RG and Maxfield FR (1997) Endocytosis. Physiol Rev, 77, 759\u2013803.","journal-title":"Physiol Rev"},{"key":"BFEMBJ7591159_CR38","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1083\/jcb.127.5.1199","volume":"127","author":"RG Parton","year":"1994","unstructured":"Parton RG, Joggerst B and Simons K (1994) Regulated internalization of caveolae. J Cell Biol, 127, 1199\u20131215.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/01.ATV.1.3.177","volume":"1","author":"RE Pitas","year":"1981","unstructured":"Pitas RE, Innerarity TL, Weinstein JN and Mahley RW (1981) Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis, 1, 177\u2013185.","journal-title":"Arteriosclerosis"},{"key":"BFEMBJ7591159_CR40","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1083\/jcb.122.6.1231","volume":"122","author":"JF Presley","year":"1993","unstructured":"Presley JF, Mayor S, Dunn KW, Johnson LS, McGraw TE and Maxfield FR (1993) The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected. J Cell Biol, 122, 1231\u20131241.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.132.1.35","volume":"132","author":"S Rijnboutt","year":"1996","unstructured":"Rijnboutt S, Jansen G, Posthuma G, Hynes JB, Schornagel JH and Strous GJ (1996) Endocytosis of GPI\u2010linked membrane folate receptor\u2010\u03b1. J Cell Biol, 132, 35\u201347.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR42","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1073\/pnas.92.9.3824","volume":"92","author":"TE Ritter","year":"1995","unstructured":"Ritter TE, Fajardo O, Matsue H, Anderson RG and Lacey SW (1995) Folate receptor targeted to clathrin\u2010coated pits cannot regulate vitamin uptake. Proc Natl Acad Sci USA, 92, 3824\u20133828.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591159_CR43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0167-5699(91)90110-F","volume":"12","author":"PJ Robinson","year":"1991","unstructured":"Robinson PJ (1991) Phosphatidylinositol membrane anchors and T\u2010cell activation. Immunol Today, 12, 35\u201341.","journal-title":"Immunol Today"},{"key":"BFEMBJ7591159_CR44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(92)90143-Z","volume":"68","author":"KG Rothberg","year":"1992","unstructured":"Rothberg KG, Heuser JE, Donzell WC, Ying Y\u2010S, Glenney JR and Anderson RGW (1992) Caveolin, a protein component of caveolae membrane coats. Cell, 68, 673\u2013682.","journal-title":"Cell"},{"key":"BFEMBJ7591159_CR45","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1083\/jcb.111.6.2931","volume":"111","author":"KG Rothberg","year":"1990","unstructured":"Rothberg KG, Ying Y\u2010S, Kamen BA and Anderson RGW (1990a) Cholesterol controls the clustering of the glycophospholipid\u2010linked membrane receptor for 5\u2010methyltetrahydrofolate. J Cell Biol, 111, 2931\u20132938.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR46","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.110.3.637","volume":"110","author":"KG Rothberg","year":"1990","unstructured":"Rothberg KG, Ying Y\u2010S, Kolhouse JF, Kamen BA and Anderson RGW (1990b) The glycophospholipid\u2010linked folate receptor internalizes folate without entering the clathrin\u2010coated pit endocytic pathway. J Cell Biol, 110, 637\u2013649.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR47","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1016\/S0021-9258(19)69057-5","volume":"256","author":"J Ryan","year":"1981","unstructured":"Ryan J, Hardeman EC, Endo A and Simoni RD (1981) Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme A reductase. J Biol Chem, 256, 6762\u20136768.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591159_CR48","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.106.4.1083","volume":"106","author":"NH Salzman","year":"1988","unstructured":"Salzman NH and Maxfield FR (1988) Intracellular fusion of sequentially formed endocytic compartments. J Cell Biol, 106, 1083\u20131091.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","volume":"387","author":"K Simons","year":"1997","unstructured":"Simons K and Ikonen E (1997) Functional rafts in membranes. Nature, 387, 569\u2013570.","journal-title":"Nature"},{"key":"BFEMBJ7591159_CR50","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1083\/jcb.134.5.1169","volume":"134","author":"EJ Smart","year":"1996","unstructured":"Smart EJ, Mineo C and Anderson RGW (1996) Clustered folate receptors deliver 5\u2010methyltetrahydrofolate to cytoplasm of MA104 cells. J Cell Biol, 134, 1169\u20131177.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR51","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1242\/jcs.110.21.2703","volume":"110","author":"C Sutterlin","year":"1997","unstructured":"Sutterlin C, Doering TL, Schimmoller F, Schroder S and Riezman H (1997) Specific requirements for the ER to Golgi transport of GPI\u2010anchored proteins in yeast. J Cell Sci, 110, 2703\u20132714.","journal-title":"J Cell Sci"},{"key":"BFEMBJ7591159_CR52","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1073\/pnas.82.2.416","volume":"82","author":"I Tabas","year":"1985","unstructured":"Tabas I, Weiland DA and Tall AR (1985) Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. Proc Natl Acad Sci USA, 82, 416\u2013420.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591159_CR53","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1083\/jcb.110.6.2117","volume":"110","author":"A Taraboulos","year":"1990","unstructured":"Taraboulos A, Serban D and Prusiner SB (1990) Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol, 110, 2117\u20132132.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.129.1.121","volume":"129","author":"A Taraboulos","year":"1995","unstructured":"Taraboulos A, Scott M, Semenov A, Avraham D, Laszlo L and Prusiner SB (1995) Cholesterol depletion and modification of COOH\u2010terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol, 129, 121\u2013132.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR55","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.57.2.551","volume":"57","author":"KT Tokuyasu","year":"1973","unstructured":"Tokuyasu KT (1973) A technique for ultracryotomy of cell suspensions and tissues. J Cell Biol, 57, 551\u2013565.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR56","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1083\/jcb.115.3.635","volume":"115","author":"J Tooze","year":"1991","unstructured":"Tooze J and Hollinshead M (1991) Tubular early endosomal networks in AtT20 and other cells. J Cell Biol, 115, 635\u2013653.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591159_CR57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cb.09.110193.001021","volume":"9","author":"IS Trowbridge","year":"1993","unstructured":"Trowbridge IS, Collawn JF and Hopkins CR (1993) Signal\u2010dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol, 9, 129\u2013161.","journal-title":"Annu Rev Cell Biol"},{"key":"BFEMBJ7591159_CR58","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1242\/jcs.106.1.423","volume":"106","author":"JJ Turek","year":"1993","unstructured":"Turek JJ, Leamon CP and Low PS (1993) Endocytosis of folate\u2013protein conjugates: ultrastructural localization in KB cells. J Cell Sci, 106, 423\u2013430.","journal-title":"J Cell Sci"},{"key":"BFEMBJ7591159_CR59","doi-asserted-by":"crossref","unstructured":"Varma R and Mayor S (1998) GPI\u2010anchored proteins are organised in sub\u2010micron sized domains at the cell surface. Nature, in press.","DOI":"10.1038\/29563"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F17.16.4626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.16.4626.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/17.16.4626\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/17.16.4626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.16.4626.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:57:57Z","timestamp":1779299877000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/17.16.4626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8,17]]},"references-count":59,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1998,8,17]]}},"alternative-id":["BFEMBJ7591159"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/17.16.4626","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8,17]]},"assertion":[{"value":"14 May 1998","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 1998","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 1998","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 1998","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}