{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:20:18Z","timestamp":1740136818712,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The range of histopathologic features of gastric syphilis is not well described. Here we describe the clinicopathologic findings of eight patients with syphilitic gastritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A search of our Pathology Data System (2003-2022) and multiple other institutions identified eight patients with syphilitic gastritis. Clinical information, pathology reports, and available slides were reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lesions predominated in middle-aged adults (mean age, 47.2 years; range, 23-61 years) with a propensity for men (n\u2005=\u20057). Three patients had a documented history of human immunodeficiency virus. Clinical presentations included weight loss, abdominal pain, hematochezia, fever, dyspepsia, nausea and vomiting, hematemesis, anemia, and early satiety. Endoscopic findings included ulcerations, erosions, abnormal mucosa, and nodularity. All specimens shared an active chronic gastritis pattern with intense lymphohistiocytic infiltrates, variable plasma cells, and gland loss. Prominent lymphoid aggregates were seen in four specimens. The diagnosis was confirmed either by immunostain for Treponema pallidum (n = 7) or by direct immunofluorescence staining and real-time polymerase chain reaction (n = 1). All patients with available follow-up data showed resolution of symptoms after antibiotic therapy (n = 4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Recognition of the histologic pattern of syphilitic gastritis facilitates timely treatment, prevents further transmission, and avoids unnecessarily aggressive treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqac153","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T01:54:06Z","timestamp":1674784446000},"page":"263-273","source":"Crossref","is-referenced-by-count":3,"title":["Histologic Features of Syphilitic Gastritis: A Rare but Resurging Imitator of Common Diseases"],"prefix":"10.1093","volume":"159","author":[{"given":"Naziheh","family":"Assarzadegan","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI , USA"}]},{"given":"Jiayun M","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI , USA"}]},{"given":"Lysandra","family":"Voltaggio","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}]},{"given":"Robert H","family":"Riddell","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto , Toronto , Canada"}]},{"given":"Elizabeth A","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Miami Miller School of Medicine , Miami, FL , USA"}]},{"given":"Oliver G","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Miami Miller School of Medicine , Miami, FL , USA"}]},{"given":"Ryan","family":"Coates","sequence":"additional","affiliation":[{"name":"Mountain States Pathology , Colorado Springs, CO , USA"}]},{"given":"Fatima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Faculty of Medicine of the University of Porto, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o , Porto , Portugal"}]},{"given":"Gregory Y","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Department of Pathology, H. Lee Moffitt Cancer Center , Tampa, FL , USA"}]},{"given":"Michal","family":"Kamionek","sequence":"additional","affiliation":[{"name":"Atrium Health University City , Charlotte, NC , USA"}]},{"given":"Laura W","family":"Lamps","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI , USA"}]},{"given":"Maria","family":"Westerhoff","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI , USA"}]}],"member":"286","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"volume-title":"Sexually Transmitted Disease Surveillance 2019","year":"2021","author":"Centers for Disease Control and Prevention.","key":"2023082514144940000_CIT0001"},{"key":"2023082514144940000_CIT0002","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00000658-192504000-00006","article-title":"Syphilis of the stomach: a critical review of reported cases from the pathological and clinical 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