{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T09:05:58Z","timestamp":1746003958448,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Pharmacologic anti-hypertensive (HT) treatment reduces cardiovascular risk. However, many patients are nonadherent due to perceived or real concern about sexual-related side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In a subset of the SPRINT (a randomized trial of intensive vs. standard blood-pressure control) trial, we sought to investigate the impact of anti-HT treatment on sexual activities of men and women over time, and whether this impact varied with a more or less intensive anti-HT therapy. Random-effects models for panel\/longitudinal data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among the 1,268 men and 613 women included in this substudy, 862 (68%) men and 178 (29%) women declared to be engaged in sexual activity of any kind. Compared with women and men not engaged in sexual activity, those engaged were younger (64 vs. 69 years for women and 65 vs. 75 years for men). Women had an overall low satisfaction with their sexual life but their sexual health was not affected by anti-HT therapy over time nor modified by an intensive treatment. Men\u2019s erections were slightly deteriorated over time (\u22120.1 to \u22120.2 points on a scale of 1 (worse) to 5 (best); P &amp;lt; 0.05), but were not aggravated by intensive anti-HT therapy (P &amp;gt; 0.05 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Self-declared women\u2019s sexual health was not affected by an intensive anti-HT therapy. Men reported a slight deterioration in the quality of their erections, irrespective of standard or intensive therapy. These findings may help reassuring patients about the sexual safety of intensive anti-HT therapy, therefore, potentially improving adherence to intensive therapy strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpab035","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T20:28:35Z","timestamp":1612556915000},"page":"760-772","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Anti-hypertensive Therapy in the Sexual Health of Men and Women: An Analysis From the SPRINT Trial"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-6138","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d\u2019Investigations Cliniques Plurith\u00e9matique Inserm 1433 , Nancy , France"},{"name":"CHRU de Nancy, Inserm U1116 , Nancy , France"},{"name":"FCRIN INI-CRCT , Nancy , France"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Saarland University Medical Center , Homburg , Germany"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d\u2019Investigations Cliniques Plurith\u00e9matique Inserm 1433 , Nancy , France"},{"name":"CHRU de Nancy, Inserm U1116 , Nancy , France"},{"name":"FCRIN INI-CRCT , Nancy , France"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Centre d\u2019Investigations Cliniques Plurith\u00e9matique Inserm 1433 , Nancy , France"},{"name":"CHRU de Nancy, Inserm U1116 , Nancy , France"},{"name":"FCRIN INI-CRCT , Nancy , France"}]}],"member":"286","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"2022100812385248200_CIT0001","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"2022100812385248200_CIT0002","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.amjhyper.2006.04.006","article-title":"Medication adherence and persistence as the cornerstone of effective antihypertensive therapy","volume":"19","author":"Burnier","year":"2006","journal-title":"Am J Hypertens"},{"key":"2022100812385248200_CIT0003","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1097\/HJH.0000000000001502","article-title":"Medication adherence among patients with apparent treatment-resistant hypertension: systematic review and meta-analysis","volume":"35","author":"Durand","year":"2017","journal-title":"J Hypertens"},{"key":"2022100812385248200_CIT0004","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1001\/archinte.1994.00420070034004","article-title":"Sexual dysfunction with antihypertensive drugs","volume":"154","author":"Prisant","year":"1994","journal-title":"Arch Intern Med"},{"key":"2022100812385248200_CIT0005","doi-asserted-by":"crossref","first-page":"908","DOI":"10.4330\/wjc.v6.i9.908","article-title":"Management of erectile dysfunction in hypertension: tips and tricks","volume":"6","author":"Viigimaa","year":"2014","journal-title":"World J Cardiol"},{"key":"2022100812385248200_CIT0006","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1749-6632.2011.06201.x","article-title":"Future self-continuity: how conceptions of the future self transform intertemporal choice","volume":"1235","author":"Hershfield","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"2022100812385248200_CIT0007","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N Engl J Med"},{"key":"2022100812385248200_CIT0008","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/1740774514537404","article-title":"The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)","volume":"11","author":"Ambrosius","year":"2014","journal-title":"Clin Trials"},{"key":"2022100812385248200_CIT0009","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. 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