{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:21:24Z","timestamp":1776496884307,"version":"3.51.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-15-RHU-0004"],"award-info":[{"award-number":["ANR-15-RHU-0004"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French PIA project \u201cLorraine Universit\u00e9 d\u2032Excellence,\u201d","award":["ANR-15-IDEX-04-LUE"],"award-info":[{"award-number":["ANR-15-IDEX-04-LUE"]}]},{"name":"European Fibro-Targets Project","award":["SP7#602904"],"award-info":[{"award-number":["SP7#602904"]}]},{"name":"European HOMAGE project","award":["305507"],"award-info":[{"award-number":["305507"]}]},{"name":"MEDIA project (Europ\u00e9en \u201cCooperation\u201d \u2013 Theme \u201cHealth\u201d\/FP7-HEALTH-2010-single-stage","award":["261409"],"award-info":[{"award-number":["261409"]}]},{"name":"FOCUS-MR","award":["ANR-15-CE14-0032-01"],"award-info":[{"award-number":["ANR-15-CE14-0032-01"]}]},{"name":"ERA-CVD EXPERT","award":["ANR-16-ECVD-0002-02"],"award-info":[{"award-number":["ANR-16-ECVD-0002-02"]}]},{"name":"Fondation de Recherche en Hypertension Art\u00e9rielle."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The attenuation of physiological nocturnal decline of blood pressure (BP)\u2014called nondipper pattern\u2014has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. This study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The STANISLAS Cohort is a single-center, familial longitudinal cohort composed of 1,006 families (4,295 subjects) recruited in 1993\u20131995 for a 5-year periodic health examination. A total of 1,334 subjects from the 4th visit (2011\u20132016) of the STANISLAS cohort were included. This 4th examination included estimated glomerular filtration rate, albumin\/creatinine ratio, pulse wave velocity, central systolic BP, carotid intima\u2013media thickness and distensibility, left ventricular mass index, left ventricular hypertrophy, diastolic dysfunction, and ambulatory blood pressure monitoring (ABPM). Nondipping status was defined as a mean reduction in systolic BP (SBP) or diastolic BP (DBP) lower than 10% during nighttime.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Data were obtained from 798 normotensive subjects (45 \u00b1 14 years, 395 [49%] nondippers, SBP\/DBP mmHg 24 hours: 116\/71 \u00b1 7\/5) and 536 hypertensive patients (56 \u00b1 11 years, 257 [48%] nondippers, SBP\/DBP mmHg 24 hours: 127\/78 \u00b1 10\/7). Mean 24-hour and daytime ABPM measurements were within the normal range, even in hypertensive participants (19% treated). The nondipping pattern was not associated with cardiovascular or renal alterations in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>In this middle-aged population with an overall 24-hour optimal BP control, the nondipper pattern was not associated with increased cardiovascular or renal damage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz020","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T21:05:05Z","timestamp":1549055105000},"page":"620-628","source":"Crossref","is-referenced-by-count":22,"title":["Nondipping Pattern and Cardiovascular and Renal Damage in a Population-Based Study (The STANISLAS Cohort Study)"],"prefix":"10.1093","volume":"32","author":[{"given":"Marilucy","family":"Lopez-Sublet","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, ESH Hypertension Excellence Centre, CHU Avicenne, AP-HP, Bobigny, France"},{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"}]},{"given":"Erwan","family":"Bozec","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"}]},{"given":"Jean-Loup","family":"Machu","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"}]},{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"},{"name":"Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"}]},{"given":"Jean-Jacques","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, ESH Hypertension Excellence Centre, CHU Avicenne, AP-HP, Bobigny, France"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"French Clinical Research Infrastructure Network Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists (FCRIN INI-CRCT), Nancy, France"},{"name":"Universit\u00e9 de Lorraine, INSERM CIC-P 1433, CHRU de Nancy, INSERM U1116, Nancy, France"}]}],"member":"286","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"2022110919181865600_CIT0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/08037051.2014.868629","article-title":"2013 ESH\/ESC practice guidelines for the management of arterial hypertension","volume":"23","author":"Mancia","year":"2014","journal-title":"Blood 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