{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:18:32Z","timestamp":1765423112431},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Physical exercise is a well-established strategy to control blood pressure. Nonetheless, its effects on protein homeostasis in individuals with hypertension are not clearly defined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>Evaluate proteostasis, quality of life, and inflammation, oxidative stress, and vasoactive biomarkers in adults with hypertension regarding reported exercise habits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Twenty individuals were recruited in a health-care centre, 10 regular exercisers (age: 68.3 \u00b1 4.2 years) and 10 age-matched individuals without regular exercise participation (age: 67.7 \u00b1 5.1 years). Proteostasis and the levels of ubiquitin, heat shock protein 70 (Hsp70), endothelial nitric oxide synthase (eNOS), matrix metalloproteinases 2 (MMP-2), tissue inhibitor of MMP-2 (TIMP-2), connexin 43 (Cx43) and extracellular superoxide dismutase-3 (SOD-3) were assessed in plasma using immunoblotting techniques (western blot or slot blot) and Fourier-transform infrared spectroscopy (FTIR). Quality of life was assessed using the Short Form 36 (SF-36) version 2.0 questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Significant higher levels of interleukin (IL)-6 (P = 0.014), eNOS (P = 0.011), Cx43 (P = 0.020), TIMP-2 (P = 0.038), and SOD-3 (P = 0.001), with a fold increase of 1.5, 1.2, 2.1, 1.3, and 1.2, respectively, were found in the exercise group. The overall quality of life (60.1 \u00b1 4.3 vs. 53.2 \u00b1 5.9, P = 0.009), as well as mental health domain (59.4 \u00b1 7.9 vs. 50.7 \u00b1 7.2, P = 0.024) were significantly higher in the exercise group. Multivariate analysis by FTIR showed that the age-matched group is characterized by peaks related with antiparallel \u03b2-sheet, whereas exercise group is characterized by peaks related to random coils, \u03b2-sheet, and \u03b1-helix.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Individuals with regular exercise participation showed better proteostasis, quality of life, inflammatory profile, antioxidant defenses, and eNOS levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpz160","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T05:24:41Z","timestamp":1569389081000},"page":"119-123","source":"Crossref","is-referenced-by-count":12,"title":["Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension"],"prefix":"10.1093","volume":"33","author":[{"given":"Manuel","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"}]},{"given":"Marisol","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"}]},{"given":"Ana","family":"Duarte","sequence":"additional","affiliation":[{"name":"Unidade Cuidados na Comunidade Cubo M\u00e1gico da Sa\u00fade , Oliveira do Bairro, Portugal"}]},{"given":"Miriam","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Unidade Cuidados na Comunidade Cubo M\u00e1gico da Sa\u00fade , Oliveira do Bairro, Portugal"}]},{"given":"Maria I","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Unidade Cuidados na Comunidade Cubo M\u00e1gico da Sa\u00fade , Oliveira do Bairro, Portugal"}]},{"given":"Maria","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Unidade Cuidados na Comunidade Cubo M\u00e1gico da Sa\u00fade , Oliveira do Bairro, Portugal"}]},{"given":"Gladys","family":"Silva","sequence":"additional","affiliation":[{"name":"C\u00e2mara Municipal de Oliveira do Bairro , Oliveira do Bairro, Portugal"}]},{"given":"Sandra","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"},{"name":"Aveiro Institute of Materials (CICECO), University of Aveiro , Aveiro, Portugal"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA & LAQV, Department of Chemistry, University of Aveiro , Aveiro, Portugal"}]},{"given":"Alexandra","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"}]},{"given":"Sandra I","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"},{"name":"The Discoveries CTR, University of Aveiro , Aveiro, Portugal"}]},{"given":"Fernando","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Institute of Biomedicine (iBiMED), University of Aveiro , Aveiro, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"2022100708274512200_CIT0001","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"2022100708274512200_CIT0002","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/ajh\/hpu203","article-title":"Effects of acute and chronic exercise in patients with essential hypertension: benefits and risks","volume":"28","author":"Gkaliagkousi","year":"2015","journal-title":"Am J Hypertens"},{"key":"2022100708274512200_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.07.005","article-title":"Protein aggregation, cardiovascular diseases, and exercise training: where do we stand?","volume":"40","author":"Gouveia","year":"2017","journal-title":"Ageing Res Rev"},{"key":"2022100708274512200_CIT0004","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-060614-033955","article-title":"The biology of proteostasis in aging and disease","volume":"84","author":"Labbadia","year":"2015","journal-title":"Annu Rev Biochem"},{"key":"2022100708274512200_CIT0005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/HYPERTENSIONAHA.115.06849","article-title":"Age- and hypertension-associated protein aggregates in mouse heart have similar proteomic profiles","volume":"67","author":"Ayyadevara","year":"2016","journal-title":"Hypertension"},{"key":"2022100708274512200_CIT0006","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1074\/jbc.R109.025023","article-title":"Autophagy in hypertensive heart disease","volume":"285","author":"Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"2022100708274512200_CIT0007","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11010-015-2326-1","article-title":"Aerobic exercise training improves oxidative stress and ubiquitin proteasome system activity in heart of spontaneously hypertensive rats","volume":"402","author":"de Andrade","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"2022100708274512200_CIT0008","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2013Alzheimer\u2019s disease of the heart?","volume":"368","author":"Willis","year":"2013","journal-title":"N Engl J Med"},{"key":"2022100708274512200_CIT0009","doi-asserted-by":"crossref","first-page":"14883","DOI":"10.1002\/jcp.28318","article-title":"Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: the role of exercise","volume":"234","author":"Batatinha","year":"2019","journal-title":"J Cell Physiol"},{"key":"2022100708274512200_CIT0010","doi-asserted-by":"crossref","first-page":"e0119382","DOI":"10.1371\/journal.pone.0119382","article-title":"Autophagic signaling and proteolytic enzyme activity in cardiac and skeletal muscle of spontaneously hypertensive rats following chronic aerobic exercise","volume":"10","author":"McMillan","year":"2015","journal-title":"PLoS One"},{"key":"2022100708274512200_CIT0011","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1397.086","article-title":"Differential distribution of Alzheimer\u2019s amyloid precursor protein family variants in human sperm","volume":"1096","author":"Fardilha","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"2022100708274512200_CIT0012","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1038\/s41598-019-41540-3","article-title":"Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems","volume":"9","author":"Santos","year":"2019","journal-title":"Sci Rep"},{"key":"2022100708274512200_CIT0013","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/jcmm.13374","article-title":"Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats","volume":"22","author":"De Moraes","year":"2018","journal-title":"J Cell Mol Med"},{"key":"2022100708274512200_CIT0014","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/05704928.2016.1230863","article-title":"Advances in Fourier transform infrared (FTIR) spectroscopy of biological tissues","volume":"52","author":"Talari","year":"2017","journal-title":"Appl Spectrosc Rev"},{"key":"2022100708274512200_CIT0015","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1021\/ja3088407","article-title":"The supramolecular chemistry of \u03b2-sheets","volume":"135","author":"Cheng","year":"2013","journal-title":"J Am Chem Soc"},{"key":"2022100708274512200_CIT0016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1071\/CH13349","article-title":"Tunable organogelator from alkyl-polypeptide diblock prepared by ring-opening polymerization","volume":"67","author":"Chen","year":"2014","journal-title":"Aust J Chem"},{"key":"2022100708274512200_CIT0017","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/344268a0","article-title":"Relative helix-forming tendencies of nonpolar amino acids","volume":"344","author":"Padmanabhan","year":"1990","journal-title":"Nature"},{"key":"2022100708274512200_CIT0018","first-page":"12391","article-title":"Are denatured proteins ever random coils?","volume":"97","author":"Baldwin","year":"2000","journal-title":"J Biol Chem"},{"key":"2022100708274512200_CIT0019","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/HYPERTENSIONAHA.109.136622","article-title":"Moderate exercise decreases inflammation and oxidative stress in hypertension: but what are the mechanisms?","volume":"54","author":"Briones","year":"2009","journal-title":"Hypertension"},{"key":"2022100708274512200_CIT0020","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijcard.2009.09.548","article-title":"Is exercise training an effective therapy targeting endothelial dysfunction and vascular wall inflammation?","volume":"141","author":"Ribeiro","year":"2010","journal-title":"Int J Cardiol"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpz160\/31168457\/hpz160.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/33\/2\/119\/46360246\/ajh_33_2_119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/33\/2\/119\/46360246\/ajh_33_2_119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T08:28:07Z","timestamp":1665131287000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/33\/2\/119\/5575318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,27]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,27]]},"published-print":{"date-parts":[[2020,2,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpz160","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2019,9,27]]}}}