{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:19:52Z","timestamp":1779135592010,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>COVID-19 has been linked to long-term respiratory and cardiovascular complications. The extent to which vaccination reduces these risks, particularly in individuals without pre-existing respiratory disease, remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used the TriNetX global health research network (105 healthcare organizations). Adults (\u226518 years) with confirmed COVID-19 between January 1, 2020, and May 1, 2022, and no prior respiratory disease were included. Two cohorts were created: (1) vaccinated (\u22651 dose of COVID-19 vaccine), and (2) unvaccinated. After 1:1 propensity score matching across 104 demographic, clinical, and laboratory variables, 75,048 patients remained in each group. Outcomes were evaluated over a 3-year follow-up, including hospitalization, pneumonia, respiratory failure, long COVID, interstitial lung disease (ILD), and cardiovascular events (stroke, pulmonary embolism, cardiac instability). Odds ratios (OR) with 95% confidence intervals (CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Vaccination significantly reduced the risk of: \u2022 Pneumonia (OR 0.29; 95% CI 0.28-0.31) \u2022 COVID-19 pneumonia (OR 0.07; 95% CI 0.06-0.09) \u2022 Acute respiratory distress syndrome (OR 0.25; 95% CI 0.20-0.31) \u2022 Respiratory failure (OR 0.45; 95% CI 0.43-0.47) \u2022 ILD (OR 0.57; 95% CI 0.51-0.64)Long COVID incidence was modestly reduced (OR 0.92; 95% CI 0.90-0.94). Cardiovascular complications were also less frequent among vaccinated individuals (all p &amp;lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COVID-19 vaccination is associated with a sustained reduction in respiratory and cardiovascular complications over three years in individuals without baseline respiratory disease. These findings underscore the long-term protective benefits of vaccination and its critical role in mitigating post-COVID-19 morbidity.<\/jats:p>\n                    <jats:p\/>\n                    <jats:p>This abstract is funded by: None<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag162.1089","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:00:36Z","timestamp":1779134436000},"source":"Crossref","is-referenced-by-count":0,"title":["D22-24 Three-year Respiratory and Cardiovascular Outcomes After Covid-19: Protective Effects of Vaccination in a Matched Cohort Study"],"prefix":"10.1093","volume":"212","author":[{"given":"M","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Internal Medicine, North Alabama Medical Center , Florence, AL,","place":["United\u00a0States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Qadeer","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , Galveston, TX,","place":["United\u00a0States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Internal Medicine, Universidad Autonoma de Centro America , San Jose,","place":["Costa Rica"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Asif","sequence":"additional","affiliation":[{"name":"Pulmonary, Critical Care, and Sleep Medicine, University of Oklahoma Health Sciences Center , Oklahoma City, OK,","place":["United\u00a0States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,15]]},"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/Supplement_1\/aamag162.1089\/68303685\/aamag162.1089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/212\/Supplement_1\/aamag162.1089\/68303685\/aamag162.1089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:00:36Z","timestamp":1779134436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/doi\/10.1093\/ajrccm\/aamag162.1089\/8680504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2026,5,15]]},"published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajrccm\/aamag162.1089","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,5,1]]},"article-number":"aamag162.1089"}}