{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:06:16Z","timestamp":1776179176330,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":6215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1093\/annonc\/mdg019","type":"journal-article","created":{"date-parts":[[2002,12,17]],"date-time":"2002-12-17T17:16:46Z","timestamp":1040145406000},"page":"29-35","source":"Crossref","is-referenced-by-count":495,"title":["A randomized double-blind multicenter phase III study offixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy"],"prefix":"10.1016","volume":"14","author":[{"given":"M.D.","family":"Green","sequence":"first","affiliation":[]},{"given":"H.","family":"Koelbl","sequence":"additional","affiliation":[]},{"given":"J.","family":"Baselga","sequence":"additional","affiliation":[]},{"given":"A.","family":"Galid","sequence":"additional","affiliation":[]},{"given":"V.","family":"Guillem","sequence":"additional","affiliation":[]},{"given":"P.","family":"Gascon","sequence":"additional","affiliation":[]},{"given":"S.","family":"Siena","sequence":"additional","affiliation":[]},{"given":"R.I.","family":"Lalisang","sequence":"additional","affiliation":[]},{"given":"H.","family":"Samonigg","sequence":"additional","affiliation":[]},{"given":"M.R.","family":"Clemens","sequence":"additional","affiliation":[]},{"given":"V.","family":"Zani","sequence":"additional","affiliation":[]},{"given":"B.C.","family":"Liang","sequence":"additional","affiliation":[]},{"given":"J.","family":"Renwick","sequence":"additional","affiliation":[]},{"given":"M.J.","family":"Piccart","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1093\/annonc\/mdg019_bb0010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.7326\/0003-4819-64-2-328","article-title":"Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia","volume":"64","author":"Bodey","year":"1966","journal-title":"Ann Intern Med"},{"key":"10.1093\/annonc\/mdg019_bb0015","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJM198806023182202","article-title":"The effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium","volume":"318","author":"Gabrilove","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdg019_bb0020","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(88)91475-4","article-title":"Effects of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy","volume":"1","author":"Morstyn","year":"1988","journal-title":"Lancet"},{"key":"10.1093\/annonc\/mdg019_bb0025","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1056\/NEJM199107183250305","article-title":"Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer","volume":"325","author":"Crawford","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1093\/annonc\/mdg019_bb0030","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0959-8049(93)90376-Q","article-title":"Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy","volume":"29A","author":"Trillet-Lenoir","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1093\/annonc\/mdg019_bb0035","series-title":"Filgrastim (r-metHuG-CSF) in Clinical Practice","first-page":"103","article-title":"Filgrastim (r-metHuG-CSF) in the chemotherapy setting","author":"Blackwell","year":"1993"},{"key":"10.1093\/annonc\/mdg019_bb0040","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1182\/blood.V88.6.1907.bloodjournal8861907","article-title":"Filgrastim (r-metHuG-CSF): the first 10 years","volume":"88","author":"Welte","year":"1996","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdg019_bb0045","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/S0301-472X(99)00112-5","article-title":"A new form of filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans","volume":"27","author":"Molineux","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1093\/annonc\/mdg019_bb0050","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1182\/blood.V74.4.1303.1303","article-title":"Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factor","volume":"74","author":"Layton","year":"1989","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdg019_bb0055","series-title":"Filgrastim (r-metHuG-CSF) in Clinical Practice","first-page":"51","article-title":"Pharmacology of filgrastim (r-metHuG-CSF)","author":"Roskos","year":"1998"},{"key":"10.1093\/annonc\/mdg019_bb0060","first-page":"249","article-title":"The uses and properties of PEG-linked proteins","volume":"9","author":"Delgado","year":"1992","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"10.1093\/annonc\/mdg019_bb0065","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1200\/JCO.2000.18.13.2522","article-title":"Randomized, dose-escalation study of SD\/01 compared with daily filgrastim in patients receiving chemotherapy","volume":"18","author":"Johnston","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdg019_bb0070","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/annonc\/mdf130","article-title":"Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer","volume":"13","author":"Holmes","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1093\/annonc\/mdg019_bb0075","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1182\/blood.V90.12.4710","article-title":"A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia","volume":"90","author":"Heil","year":"1997","journal-title":"Blood"},{"key":"10.1093\/annonc\/mdg019_bb0080","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1200\/JCO.20.3.727","article-title":"Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III\/IV breast cancer","volume":"20","author":"Holmes","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1093\/annonc\/mdg019_bb0085","first-page":"157b","article-title":"Pharmacokinetic rationale for a fixed-dose regimen of a sustained-duration form of filgrastim in cancer patients","volume":"96","author":"Yang","year":"2000","journal-title":"Blood"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753419639104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/annonc\/article-pdf\/14\/1\/29\/302428\/mdg019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T21:10:06Z","timestamp":1582233006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753419639104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0923753419639104"],"URL":"https:\/\/doi.org\/10.1093\/annonc\/mdg019","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}