{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:19:12Z","timestamp":1790169552462,"version":"4.1.0"},"reference-count":16,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Suntory Beverage and Food Limited"},{"name":"Orthomedico Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Mulberry leaf extract (MLE) has known as inhibits elevated postprandial blood glucose level in human. Then, we conducted a randomized, double-blind placebo-controlled parallel-group trial to evaluate safety when a green tea containing MLE is consumed 3 times a day, every day for 4 weeks. The participants (n = 48) were randomly allocated into 2 groups, an MLE beverage group and a control beverage group. The subjects were instructed to drink either a 500 mL green tea containing 550 mg MLE or a 500 mL green tea not containing MLE, 3 times a day, every day, for 4 weeks. No adverse reactions were observed over the 4 weeks trial, and no difference in the incidence of adverse events between the groups. These findings demonstrate that the consumption of a green tea containing 550 mg MLE 3 times a day for 4 weeks is safe for healthy adults.<\/jats:p>","DOI":"10.1093\/bbb\/zbac011","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T21:41:23Z","timestamp":1643406083000},"page":"519-527","source":"Crossref","is-referenced-by-count":10,"title":["Safety evaluation of a beverage containing mulberry leaf extract"],"prefix":"10.1080","volume":"86","author":[{"given":"Keisuke","family":"Yasumoto","sequence":"first","affiliation":[{"name":"Suntory MONOZUKURI Expert Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hoshiko","sequence":"additional","affiliation":[{"name":"Suntory MONOZUKURI Expert Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Suntory MONOZUKURI Expert Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Obata","sequence":"additional","affiliation":[{"name":"Suntory MONOZUKURI Expert Limited, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takara","sequence":"additional","affiliation":[{"name":"Takara Clinic, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"2022032516115483300_bib1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jff.2013.04.015","article-title":"Acute intake of mulberry leaf aqueous extract affects postprandial glucose response after maltose loading: randomized double-blind placebo-controlled pilot study","volume":"5","author":"Chung","year":"2013","journal-title":"J Funct Foods"},{"key":"2022032516115483300_bib2","article-title":"Consumer Affairs Agency. 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