{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:35:10Z","timestamp":1769024110126,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1428,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories. Negatively correlated profiles can be used to generate hypotheses of drug-repurposing, whereas positively correlated profiles may be used to infer side effects of drugs. DvD allows users to compare drug and disease signatures with dynamic access to databases Array Express, Gene Expression Omnibus and data from the Connectivity Map.<\/jats:p>\n               <jats:p>Availability and implementation: R package (submitted to Bioconductor) under GPL 3 and Cytoscape plug-in freely available for download at www.ebi.ac.uk\/saezrodriguez\/DVD\/.<\/jats:p>\n               <jats:p>Contact: \u00a0saezrodriguez@ebi.ac.uk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bts656","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T03:08:43Z","timestamp":1352171323000},"page":"132-134","source":"Crossref","is-referenced-by-count":70,"title":["DvD: An R\/Cytoscape pipeline for drug repurposing using public repositories of gene expression data"],"prefix":"10.1093","volume":"29","author":[{"given":"Clare","family":"Pacini","sequence":"first","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"}]},{"given":"Francesco","family":"Iorio","sequence":"additional","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"},{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"}]},{"given":"Emanuel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"}]},{"given":"Murat","family":"Iskar","sequence":"additional","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"}]},{"given":"Thomas","family":"Klabunde","sequence":"additional","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK, CB10 1HH, 3Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 4Sanofi-Aventis Deutschland GmbH, Frankurt am Main, Germany"}]},{"given":"Peer","family":"Bork","sequence":"additional","affiliation":[{"name":"1 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK CB10 1SD, 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