{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:13:33Z","timestamp":1767982413075,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":549,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Ebola virus causes high mortality hemorrhagic fevers, with more than 25\u2009000 cases and 10\u2009000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed.<\/jats:p>\n               <jats:p>Results: Analysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that appear nowhere in the human genome. We identify the shortest such sequences with lengths between 12 and 14. Only three absent sequences of length 12 exist and they consistently appear at the same location on two of the Ebola virus proteins, in all Ebola virus genomes, but nowhere in the human genome. The alignment-free method used is able to identify pathogen-specific signatures for quick and precise action against infectious agents, of which the current Ebola virus outbreak provides a compelling example.<\/jats:p>\n               <jats:p>Availability and Implementation: EAGLE is freely available for non-commercial purposes at http:\/\/bioinformatics.ua.pt\/software\/eagle.<\/jats:p>\n               <jats:p>Contact: \u00a0raquelsilva@ua.pt; pratas@ua.pt<\/jats:p>\n               <jats:p>Supplementary Information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv189","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T00:12:32Z","timestamp":1428106352000},"page":"2421-2425","source":"Crossref","is-referenced-by-count":42,"title":["Three minimal sequences found in Ebola virus genomes and absent from human DNA"],"prefix":"10.1093","volume":"31","author":[{"given":"Raquel M.","family":"Silva","sequence":"first","affiliation":[{"name":"1 IEETA and"}]},{"given":"Diogo","family":"Pratas","sequence":"additional","affiliation":[{"name":"1 IEETA and"},{"name":"2 DETI, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Lu\u00edsa","family":"Castro","sequence":"additional","affiliation":[{"name":"1 IEETA and"}]},{"given":"Armando J.","family":"Pinho","sequence":"additional","affiliation":[{"name":"1 IEETA and"},{"name":"2 DETI, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Paulo J. S. G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"1 IEETA and"},{"name":"2 DETI, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"2023051308484926900_btv189-B1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJMoa1404505","article-title":"Emergence of Zaire Ebola virus disease in Guinea","volume":"371","author":"Baize","year":"2014","journal-title":"N. Engl. J. 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