{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:46:29Z","timestamp":1773787589157,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endocrine-disrupting chemicals have become an issue of scientific and public discussion. Vinclozolin (VNZ) is a fungicide that competitively antagonizes the binding of natural androgens to their receptor, disturbing the function of tissues that are sensitive to these hormones, as is the case of the male reproductive organs. A systematic review with meta-analyses of rodent studies was conducted to answer the following question: Does exposure to VNZ affect sperm parameters and testicular\/epididymal weight? The methodology was prespecified according to the Cochrane Handbook for Systematic Reviews and PRISMA recommendations. Sixteen articles met the inclusion criteria, comprising a total of 1189 animals. The risk of publication bias was assessed using the Trim and Fill adjustment, funnel plot, and Egger regression test. Heterogeneity and inconsistency across the findings were tested using the Q-statistic and I2 of Higgins, respectively. Sensitivity was also analyzed. Statistical analysis was performed on Comprehensive Meta-Analysis software (Version 2.0), using random models and weighted mean differences along with a 95% confidence interval. Sperm motility, counts, daily sperm production (evidence of publication bias), and epididymis weight were decreased in VNZ-treated animals. Exposure length and dose, as well as the time point of exposure, influenced the obtained results. Despite the moderate\/high heterogeneity observed, the sensitivity analysis overall demonstrated the robustness of the findings. The quality scores of the included studies were superior to 4 in a total of 9, then classified as good. The obtained data corroborate the capability of VNZ exposure to disrupt spermatogenic output and compromise male fertility.<\/jats:p>","DOI":"10.1093\/biolre\/ioab018","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T04:43:38Z","timestamp":1612327418000},"page":"962-975","source":"Crossref","is-referenced-by-count":13,"title":["Effects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysis\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Mariana","family":"Feij\u00f3","sequence":"first","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilh\u00e3, Portugal"},{"name":"GRUBI, Group of Systematic Reviews of University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Roberta V L","family":"Martins","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"S\u00edlvia","family":"Socorro","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Lu\u00edsa","family":"Pereira","sequence":"additional","affiliation":[{"name":"GRUBI, Group of Systematic Reviews of University of Beira Interior, Covilh\u00e3, Portugal"},{"name":"CMA-UBI, Centre for Mathematics and Applications, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Sara","family":"Correia","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilh\u00e3, Portugal"},{"name":"GRUBI, Group of Systematic Reviews of University of Beira Interior, Covilh\u00e3, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"2021051106564854700_ref1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1289\/ehp.1103767","article-title":"Birth 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