{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:26:06Z","timestamp":1770747966923,"version":"3.49.0"},"reference-count":184,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Funds through FCT-Foundation for Science and Technology","award":["Pest-OE\/SAU\/UI0215\/2014"],"award-info":[{"award-number":["Pest-OE\/SAU\/UI0215\/2014"]}]},{"name":"FCT through FSE and POPH funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/biolre\/ioy215","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T15:20:00Z","timestamp":1538580000000},"page":"318-330","source":"Crossref","is-referenced-by-count":18,"title":["Shedding light into the relevance of telomeres in human reproduction and male factor infertility\u2020"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-8199","authenticated-orcid":false,"given":"Ana Catarina","family":"Lopes","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology, Department of Microscopy, and Multidisciplinary Unit for Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Department of Life Sciences, Faculty of Sciences and Technology, New University of Lisbon (FCT-UNL), Campus Caparica, Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Department of Microscopy, and Multidisciplinary Unit for Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Department of Genetics, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"i3S- Institute of Research and Innovation in Health, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-3290","authenticated-orcid":false,"given":"M\u00e1rio","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Department of Microscopy, and Multidisciplinary Unit for Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal"},{"name":"Centre for Reproductive Genetics Professor Alberto Barros, Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"key\n\t\t\t\t2019021807303991800_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib2","first-page":"181","article-title":"The remaking of chromosomes","volume":"13","author":"Muller","year":"1938","journal-title":"Collect Net"},{"key":"key\n\t\t\t\t2019021807303991800_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","article-title":"The stability of broken ends of chromosomes in Zea mays","volume":"26","author":"McClintock","year":"1941","journal-title":"Genetics"},{"key":"key\n\t\t\t\t2019021807303991800_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0022-2836(78)90294-2","article-title":"A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena","volume":"120","author":"Blackburn","year":"1978","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(82)90109-X","article-title":"Cloning yeast telomeres on linear plasmid vectors","volume":"29","author":"Szostak","year":"1982","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0092-8674(84)90295-2","article-title":"Telomeres: Do the ends justify the means?","volume":"37","author":"Blackburn","year":"1984","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/and.12008","article-title":"Telomere length in reproduction","volume":"45","author":"Thilagavathi","year":"2013","journal-title":"Andrologia"},{"key":"key\n\t\t\t\t2019021807303991800_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00412-015-0555-4","article-title":"Telomere homeostasis in mammalian germ cells: a review","volume":"125","author":"Reig-Viader","year":"2016","journal-title":"Chromosoma"},{"key":"key\n\t\t\t\t2019021807303991800_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.genet.34.1.331","article-title":"Telomeres and their control","volume":"34","author":"McEachern","year":"2000","journal-title":"Annu Rev Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib10","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib11","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.86.18.7049","article-title":"Conservation of the human telomere sequence (TTAGGG)n among vertebrates","volume":"86","author":"Meyne","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib12","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1101\/gad.11.21.2801","article-title":"Normal human chromosomes have long G-rich telomeric overhangs at one end","volume":"11","author":"Wright","year":"1997","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t2019021807303991800_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.aanat.2010.07.005","article-title":"Sizing the ends: normal length of human telomeres","volume":"192","author":"Samassekou","year":"2010","journal-title":"Ann Anat"},{"key":"key\n\t\t\t\t2019021807303991800_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(00)80760-6","article-title":"Mammalian telomeres end in a large duplex loop","volume":"97","author":"Griffith","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu Rev Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib16","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.283.5406.1321","article-title":"p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2","volume":"283","author":"Karlseder","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0092-8674(87)90577-0","article-title":"Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine\u00b7guanine base pairs","volume":"51","author":"Henderson","year":"1987","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-1-4939-6892-3_17","article-title":"Human telomeric G-quadruplex structures and G-quadruplex-interactive compounds","volume":"1587","author":"Lin","year":"2017","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib19","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1128\/MCB.14.9.5777","article-title":"Unusual chromatin in human telomeres","volume":"14","author":"Tommerup","year":"1994","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib20","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.1147182","article-title":"Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends","volume":"318","author":"Azzalin","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib21","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: The protein complex that shapes and safeguards human telomeres","volume":"19","author":"de Lange","year":"2005","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t2019021807303991800_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ng1097-231","article-title":"Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2","volume":"17","author":"Broccoli","year":"1997","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cell.2013.09.048","article-title":"Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation","volume":"155","author":"Doksani","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1126\/science.1170633","article-title":"How telomeres solve the end-protection problem","volume":"326","author":"de Lange","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib25","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.1060036","article-title":"Pot1, the putative telomere end-binding protein in fission yeast and humans","volume":"292","author":"Baumann","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2006.05.037","article-title":"Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres","volume":"126","author":"Wu","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib27","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nature06065","article-title":"Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1","volume":"448","author":"Denchi","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)80858-2","article-title":"Identification of human Rap1: Implications for telomere evolution","volume":"101","author":"Li","year":"2000","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/70508","article-title":"TIN2, a new regulator of telomere length in human cells","volume":"23","author":"Kim","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib30","doi-asserted-by":"crossref","first-page":"51338","DOI":"10.1074\/jbc.M409293200","article-title":"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins","volume":"279","author":"Liu","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019021807303991800_bib31","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1101\/gad.1215404","article-title":"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2\/TRF1 complex","volume":"18","author":"Ye","year":"2004","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t2019021807303991800_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrm3505","article-title":"Finding the end: Recruitment of telomerase to telomeres","volume":"14","author":"Nandakumar","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/nucl.2.2.15135","article-title":"Shelterin complex and associated factors at human telomeres","volume":"2","author":"Diotti","year":"2011","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t2019021807303991800_bib34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(01)00492-5","article-title":"Switching and signaling at the telomere","volume":"106","author":"Blackburn","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib35","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1126\/science.1069523","article-title":"Senescence induced by altered telomere state, not telomere loss","volume":"295","author":"Karlseder","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/35040500","article-title":"Telomere states and cell fates","volume":"408","author":"Blackburn","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(01)00504-9","article-title":"The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability","volume":"107","author":"Hemann","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-5193(73)90198-7","article-title":"A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon","volume":"41","author":"Olovnikov","year":"1973","journal-title":"J Theor Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/newbio239197a0","article-title":"Origin of concatemeric T7DNA","volume":"239","author":"Watson","year":"1972","journal-title":"Nat New Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib40","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.molcel.2005.12.004","article-title":"Human telomeres have different overhang sizes at leading versus lagging strands","volume":"21","author":"Chai","year":"2006","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"von Zglinicki","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.exger.2010.01.009","article-title":"Abrupt telomere shortening in normal human fibroblasts","volume":"45","author":"Vida\u010deka","year":"2010","journal-title":"Exp Gerontol"},{"key":"key\n\t\t\t\t2019021807303991800_bib43","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/emboj.2009.42","article-title":"Control of telomere length by a trimming mechanism that involves generation of t-circles","volume":"28","author":"Pickett","year":"2009","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019021807303991800_bib44","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib45","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","article-title":"Telomere length predicts replicative capacity of human fibroblasts","volume":"89","author":"Allsopp","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"Greider","year":"1985","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib47","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(87)90576-9","article-title":"The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity","volume":"51","author":"Greider","year":"1987","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib48","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/excr.1999.4602","article-title":"Normal human telomeres are not late replicating","volume":"251","author":"Wright","year":"1999","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib49","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng","year":"1995","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.277.5328.955","article-title":"Telomerase catalytic subunit homologs from fission yeast and human","volume":"277","author":"Nakamura","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib51","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/ng1297-498","article-title":"Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT","volume":"17","author":"Weinrich","year":"1997","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1101\/gad.263863.115","article-title":"Human telomerase: biogenesis, trafficking, recruitment, and activation","volume":"29","author":"Schmidt","year":"2015","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t2019021807303991800_bib53","first-page":"1216","article-title":"Synthesis of the telomeric C-strand. A review","volume":"62","author":"Price","year":"1997","journal-title":"Biochemistry (Mosc)"},{"key":"key\n\t\t\t\t2019021807303991800_bib54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000167810","article-title":"Telomerase recruitment to telomeres","volume":"122","author":"Stern","year":"2008","journal-title":"Cytogenet Genome Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.biochem.73.071403.160049","article-title":"Regulation of telomerase by telomeric proteins","volume":"73","author":"Smogorzewska","year":"2004","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t2019021807303991800_bib56","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nsmb1286","article-title":"MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control","volume":"14","author":"Wu","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib57","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.celrep.2015.10.035","article-title":"ATM kinase is required for telomere elongation in mouse and human cells","volume":"13","author":"Lee","year":"2015","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t2019021807303991800_bib58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.onc.1206063","article-title":"hTERT associates with human telomeres and enhances genomic stability and DNA repair","volume":"22","author":"Sharma","year":"2003","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019021807303991800_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1432-0436.2002.690412.x","article-title":"Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again","volume":"69","author":"Forsyth","year":"2002","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t2019021807303991800_bib60","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019021807303991800_bib61","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jcp.24537","article-title":"Telomere length maintenance, shortening, and lengthening","volume":"229","author":"Zhao","year":"2014","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019021807303991800_bib62","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere diseases","volume":"361","author":"Calado","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019021807303991800_bib63","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1349-7006.2008.00831.x","article-title":"Telomere length and the risk of lung cancer","volume":"99","author":"Jang","year":"2008","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib64","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1182\/blood-2007-02-075598","article-title":"Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita","volume":"110","author":"Alter","year":"2007","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019021807303991800_bib65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/rej.2010.1085","article-title":"A natural product telomerase activator as part of a health maintenance program","volume":"14","author":"Harley","year":"2011","journal-title":"Rejuvenation Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib66","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/genes7070039","article-title":"Therapeutic targeting of telomerase","volume":"7","author":"J\u00e4ger","year":"2016","journal-title":"Genes"},{"key":"key\n\t\t\t\t2019021807303991800_bib67","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.4049\/jimmunol.181.10.7400","article-title":"Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T Lymphocytes","volume":"181","author":"Fauce","year":"2008","journal-title":"J Immun"},{"key":"key\n\t\t\t\t2019021807303991800_bib68","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1089\/rej.2015.1793","article-title":"A natural product telomerase activator lengthens telomeres in humans: A randomized, double blind, and placebo controlled study","volume":"19","author":"Salvador","year":"2016","journal-title":"Rejuvenation Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib69","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1474-9726.2011.00700.x","article-title":"The telomerase activator TA-65 elongates short telomeres and increases health span of adult\/old mice without increasing cancer incidence","volume":"10","author":"Bernardes de Jesus","year":"2011","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.semcancer.2011.10.001","article-title":"Role of telomeres and telomerase in cancer","volume":"21","author":"Shay","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib71","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1158\/2159-8290.CD-16-0062","article-title":"Role of telomeres and telomerase in aging and cancer","volume":"6","author":"Shay","year":"2016","journal-title":"Cancer Discov"},{"key":"key\n\t\t\t\t2019021807303991800_bib72","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/hmg\/6.6.921","article-title":"The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit","volume":"6","author":"Bryan","year":"1997","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib73","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3835(02)00702-4","article-title":"Alternative lengthening of telomeres, telomerase, and cancer","volume":"194","author":"Reddel","year":"2003","journal-title":"Cancer Lett"},{"key":"key\n\t\t\t\t2019021807303991800_bib74","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib75","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fonc.2013.00027","article-title":"Alternative lengthening of telomeres: remodeling the telomere architecture","volume":"3","author":"Conomos","year":"2013","journal-title":"Front Oncol"},{"key":"key\n\t\t\t\t2019021807303991800_bib76","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nsmb.3106","article-title":"Molecular mechanisms of activity and derepression of alternative lengthening of telomeres","volume":"22","author":"Pickett","year":"2015","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib77","first-page":"2615","article-title":"Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands","volume":"45","author":"Min","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib78","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1093\/humrep\/dex288","article-title":"Genomic fragmentation and extrachromosomal telomeric repeats impact assessment of telomere length in human spermatozoa: quantitative experiments and systematic review","volume":"32","author":"Kurjanowicz","year":"2017","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib79","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4161\/cc.19632","article-title":"The role of telomere trimming in normal telomere length dynamics","volume":"11","author":"Pickett","year":"2012","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t2019021807303991800_bib80","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1093\/hmg\/ddr402","article-title":"Normal mammalian cells negatively regulate telomere length by telomere trimming","volume":"20","author":"Pickett","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib81","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/ncb1664","article-title":"Telomere lengthening early in development","volume":"9","author":"Liu","year":"2007","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib82","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/j.1460-2075.1992.tb05104.x","article-title":"Human telomeres are attached to the nuclear matrix","volume":"11","author":"de Lange","year":"1992","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019021807303991800_bib83","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00018-006-6463-2","article-title":"Telomeres and meiosis in health and disease","volume":"64","author":"Scherthan","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib84","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb3132","article-title":"The telomere bouquet regulates meiotic centromere assembly","volume":"17","author":"Klutstein","year":"2015","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib85","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00439-006-0137-x","article-title":"Allele-specific relative telomere lengths are inherited","volume":"119","author":"Graakjaer","year":"2006","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib86","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/hmg\/ddi424","article-title":"Telomere instability in the male germline","volume":"15","author":"Baird","year":"2006","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib87","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1098-2795(199809)51:1<98::AID-MRD12>3.0.CO;2-Q","article-title":"Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays","volume":"51","author":"Kozik","year":"1998","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t2019021807303991800_bib88","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/molehr\/5.9.845","article-title":"Alternative splicing of the telomerase catalytic subunit in human oocytes and embryos","volume":"5","author":"Brenner","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib89","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.fertnstert.2014.12.115","article-title":"Oocyte competency is the key to embryo potential","volume":"103","author":"Keefe","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019021807303991800_bib90","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1177\/1933719116676397","article-title":"Telomeres, reproductive aging, and genomic instability during early development","volume":"23","author":"Keefe","year":"2016","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ejhg.2014.65","article-title":"Possible technical and biological explanations for the \u2018parental telomere length inheritance discrepancy\u2019 enigma","volume":"23","author":"De Meyer","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib92","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4419-6857-9_2","article-title":"Spermatogenesis: An overview","volume-title":"Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction","author":"Sharma","year":"2011"},{"key":"key\n\t\t\t\t2019021807303991800_bib93","doi-asserted-by":"crossref","first-page":"e52944","DOI":"10.1371\/journal.pone.0052944","article-title":"Positioning of chromosomes in human spermatozoa is determined by ordered centromere arrangement","volume":"7","author":"Mudrak","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019021807303991800_bib94","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1242\/jcs.02581","article-title":"Chromosome architecture in the decondensing human sperm nucleus","volume":"118","author":"Mudrak","year":"2005","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib95","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF00357684","article-title":"Well-defined genome architecture in the human sperm nucleus","volume":"103","author":"Zalensky","year":"1995","journal-title":"Chromosoma"},{"key":"key\n\t\t\t\t2019021807303991800_bib96","doi-asserted-by":"crossref","first-page":"41585","DOI":"10.1038\/srep41585","article-title":"A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions","volume":"7","author":"Ioannou","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019021807303991800_bib97","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.fertnstert.2014.07.381","article-title":"Global telomere organisation in the 3D human sperm nucleus: a new arrangement and inferences for fertilization and embryogenesis","volume":"102","author":"Ioannou","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019021807303991800_bib98","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/19396368.2010.502587","article-title":"Disruption of telomere-telomere interactions associated with DNA damage in human spermatozoa","volume":"56","author":"Moskovtsev","year":"2010","journal-title":"Syst Biol Reprod Med"},{"key":"key\n\t\t\t\t2019021807303991800_bib99","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10577-005-5513-1","article-title":"Nature of telomere dimers and chromosome looping in human spermatozoa","volume":"12","author":"Solov\u2019eva","year":"2004","journal-title":"Chromosome Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/excr.1997.3482","article-title":"Telomere-telomere interactions and candidate telomere binding protein(s) in mammalian sperm cells","volume":"232","author":"Zalensky","year":"1997","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib101","doi-asserted-by":"crossref","first-page":"e303","DOI":"10.1016\/j.fertnstert.2016.07.859","article-title":"Segmented hairpin-loop organization of chromosomes in sperm nuclei: implications for fertilization and embryogenesis","volume":"106","author":"Ioannou","year":"2016","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019021807303991800_bib102","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1083\/jcb.151.7.1591","article-title":"Human sperm telomere-binding complex involves histone H2B and secures telomere membrane attachment","volume":"151","author":"Gineitis","year":"2000","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib103","first-page":"155","article-title":"Chromatin dynamics during spermiogenesis","volume":"1839","author":"Rathke","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t2019021807303991800_bib104","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/bbrc.2000.3917","article-title":"Chromatin structure of telomere domain in human sperm","volume":"279","author":"Zalenskaya","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t2019021807303991800_bib105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/BST0350609","article-title":"Organization of chromosomes in spermatozoa: an additional layer of epigenetic information","volume":"35","author":"Zalensky","year":"2007","journal-title":"Biochm Soc Trans"},{"key":"key\n\t\t\t\t2019021807303991800_bib106","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3","article-title":"Telomerase activity in human germline and embryonic tissues and cells","volume":"18","author":"Wright","year":"1996","journal-title":"Dev Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib107","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021807303991800_bib108","first-page":"805","article-title":"Expression of the RNA component of telomerase during human development and differentiation","volume":"9","author":"Yashima","year":"1998","journal-title":"Cell Growth Differ"},{"key":"key\n\t\t\t\t2019021807303991800_bib109","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.maturitas.2013.05.001","article-title":"Age-dependence of relative telomere length profiles during spermatogenesis in man","volume":"75","author":"J\u00f8rgensen","year":"2013","journal-title":"Maturitas"},{"key":"key\n\t\t\t\t2019021807303991800_bib110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1095\/biolreprod.113.116954","article-title":"Telomeric repeat-containing RNA (TERRA) and telomerase are components of telomeres during mammalian gametogenesis","volume":"90","author":"Reig-Viader","year":"2014","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib111","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/humrep\/des363","article-title":"Telomeric repeat-containing RNA and telomerase in human fetal oocytes","volume":"28","author":"Reig-Viader","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib112","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s10815-015-0574-3","article-title":"A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age","volume":"32","author":"Antunes","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib113","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/molehr\/gas028","article-title":"Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans","volume":"18","author":"Aston","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib114","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/molehr\/gat021","article-title":"Telomere lengths in human pronuclei, oocytes and spermatozoa","volume":"19","author":"Turner","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib115","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/humrep\/dev144","article-title":"Sperm telomere length is positively associated with the quality of early embryonic development","volume":"30","author":"Yang","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib116","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1073\/pnas.0702703104","article-title":"Telomere length is paternally inherited and is associated with parental lifespan","volume":"104","author":"Njajou","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib117","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1371\/journal.pgen.0040037","article-title":"Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm","volume":"4","author":"Kimura","year":"2008","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib118","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/acel.12334","article-title":"Paternal age and telomere length in twins: The germ stem cell selection paradigm","volume":"14","author":"Hjelmborg","year":"2015","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib119","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/ejhg.2012.303","article-title":"Meta-analysis of telomere length in 19713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect","volume":"21","author":"Broer","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib120","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1073\/pnas.1202092109","article-title":"Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants","volume":"109","author":"Eisenberg","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib121","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1474-9728.2005.00144.x","article-title":"Paternal age is positively linked to telomere length of children","volume":"4","author":"Unryn","year":"2005","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib122","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1093\/hmg\/ddm271","article-title":"Paternal age at birth is an important determinant of offspring telomere length","volume":"16","author":"De Meyer","year":"2007","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib123","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1093\/humrep\/det392","article-title":"In young men sperm telomere length is related to sperm number and parental age","volume":"28","author":"Ferlin","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib124","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ajhb.21127","article-title":"An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effects","volume":"23","author":"Eisenberg","year":"2011","journal-title":"Am J Hum Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13039-016-0224-1","article-title":"The paradox of longer sperm telomeres in older men's testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline","volume":"9","author":"Stindl","year":"2016","journal-title":"Mol Cytogenet"},{"key":"key\n\t\t\t\t2019021807303991800_bib126","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ejhg.2009.178","article-title":"Large-scale parent-child comparison confirms a strong paternal influence on telomere length","volume":"18","author":"Nordfjall","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib127","first-page":"133","article-title":"Making eggs","volume-title":"Essential Reproduction","author":"Johnson","year":"2013","edition":"7th ed"},{"key":"key\n\t\t\t\t2019021807303991800_bib128","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/molehr\/7.10.947","article-title":"Characterization of telomerase activity in the human oocyte and preimplantation embryo","volume":"7","author":"Wright","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib129","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/01.gco.0000193019.05686.49","article-title":"The telomere theory of reproductive senescence in women","volume":"18","author":"Keefe","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"key\n\t\t\t\t2019021807303991800_bib130","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF00204931","article-title":"A test of the production line hypothesis of mammalian oogenesis","volume":"88","author":"Polani","year":"1991","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib131","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/218022a0","article-title":"Chiasma frequency and maternal age in mammals","volume":"218","author":"Henderson","year":"1968","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib132","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0035-1567823","article-title":"Telomeres and female reproductive aging","volume":"33","author":"Kalmbach","year":"2015","journal-title":"Semin Reprod Med"},{"key":"key\n\t\t\t\t2019021807303991800_bib133","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.rbmo.2013.12.010","article-title":"Telomere length in human blastocysts","volume":"28","author":"Mania","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t2019021807303991800_bib134","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/B:JARG.0000031249.37862.3a","article-title":"Feasibility of human telomerase reverse transcriptase mRNA expression in individual blastomeres as an indicator of early embryo development","volume":"21","author":"Wang","year":"2004","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib135","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/molehr\/gaq048","article-title":"Telomere lengths in human oocytes, cleavage stage embryos and blastocysts","volume":"16","author":"Turner","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib136","doi-asserted-by":"crossref","first-page":"e1002161","DOI":"10.1371\/journal.pgen.1002161","article-title":"Telomere DNA deficiency is associated with development of human embryonic aneuploidy","volume":"7","author":"Treff","year":"2011","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib137","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/molehr\/3.9.769","article-title":"Developmental regulation of telomerase activity in human fetal tissues during gestation","volume":"3","author":"Ulaner","year":"1997","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib138","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1073\/pnas.0402400101","article-title":"Telomere length is reset during early mammalian embryogenesis","volume":"101","author":"Schaetzlein","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019021807303991800_bib139","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.rbmo.2014.03.009","article-title":"Telomere length and aneuploidy: Clinical and biological insights into human preimplantation embryos","volume":"28","author":"Simpson","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t2019021807303991800_bib140","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1242\/jcs.131433","article-title":"Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells","volume":"127","author":"Zeng","year":"2014","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib141","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/humupd\/dmg034","article-title":"Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men","volume":"9","author":"Chemes","year":"2003","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t2019021807303991800_bib142","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/1008-682X.122203","article-title":"Oxidative stress and male reproductive health","volume":"16","author":"Aitken","year":"2014","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib143","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1017\/S0967199413000671","article-title":"Effect of in vitro exposure to lead chloride on semen quality and sperm DNA fragmentation","volume":"23","author":"Gomes","year":"2015","journal-title":"Zygote"},{"key":"key\n\t\t\t\t2019021807303991800_bib144","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t2019021807303991800_bib145","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/j.1939-4640.2001.tb02572.x","article-title":"Male infertility genetics-the future","volume":"22","author":"Cram","year":"2001","journal-title":"J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib146","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/humrep\/dew061","article-title":"Sperm telomere length as a parameter of sperm quality in normozoospermic men","volume":"31","author":"Rocca","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib147","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1530\/REP-17-0018","article-title":"Obesity, energy balance and spermatogenesis","volume":"153","author":"Oliveira","year":"2017","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t2019021807303991800_bib148","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/aja.2011.66","article-title":"Chromosomal disorders and male infertility","volume":"14","author":"Harton","year":"2012","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib149","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/rep.0.1260013","article-title":"The genetic basis of infertility","volume":"126","author":"Shah","year":"2003","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t2019021807303991800_bib150","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/and.12362","article-title":"Sperm aneuploidy in infertile male patients: A systematic review of the literature","volume":"47","author":"Chatziparasidou","year":"2015","journal-title":"Andrologia"},{"key":"key\n\t\t\t\t2019021807303991800_bib151","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/1008-682X.172827","article-title":"Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia","volume":"19","author":"Gon\u00e7alves","year":"2017","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib152","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.2047-2927.2014.00231.x","article-title":"Treatment by testicular sperm extraction and intracytoplasmic sperm injection of 65 azoospermic patients with non-mosaic Klinefelter syndrome with birth of 17 healthy children","volume":"2","author":"Madureira","year":"2014","journal-title":"Andrology"},{"key":"key\n\t\t\t\t2019021807303991800_bib153","doi-asserted-by":"crossref","first-page":"079","DOI":"10.1159\/000149785","article-title":"Molecular and functional characterization of CBAVD-causing mutations located in CFTR nucleotide-binding domains","volume":"22","author":"Grangeia","year":"2008","journal-title":"Cell Physiol Biochem"},{"key":"key\n\t\t\t\t2019021807303991800_bib154","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10815-015-0474-6","article-title":"Mutation analysis in patients with total sperm immotility","volume":"32","author":"Pereira","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/1008-682X.167716","article-title":"Major regulatory mechanisms involved in sperm motility","volume":"19","author":"Pereira","year":"2017","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib156","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/humrep\/deh727","article-title":"Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality","volume":"20","author":"Almeida","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib157","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1111\/j.1365-2605.2011.01151.x","article-title":"Caspase-3 detection in human testicular spermatozoa from azoospermic and non-azoospermic patients","volume":"34","author":"Almeida","year":"2011","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t2019021807303991800_bib158","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00404-012-2440-1","article-title":"Relationship of sperm DNA fragmentation, apoptosis and dysfunction of mitochondrial membrane potential with semen parameters and ART outcome after intracytoplasmic sperm injection","volume":"286","author":"Sharbatoghli","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t2019021807303991800_bib159","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4419-6857-9_17","article-title":"Sperm epigenetic profile","volume-title":"Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction","author":"Marques","year":"2011"},{"key":"key\n\t\t\t\t2019021807303991800_bib160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/CBO9781139169349.005","article-title":"Imprinted gene anomalies in sperm","volume-title":"Paternal Influences on Human Reproductive Success","author":"Marques","year":"2013"},{"key":"key\n\t\t\t\t2019021807303991800_bib161","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.repbio.2017.10.007","article-title":"Alterations in sperm DNA methylation patterns of oligospermic males","volume":"17","author":"Laqqan","year":"2017","journal-title":"Reprod Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib162","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/humrep\/dep465","article-title":"Sperm DNA: organization, protection and vulnerability: From basic science to clinical applications-a position report","volume":"25","author":"Barratt","year":"2010","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib163","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.rbmo.2015.06.019","article-title":"Sperm DNA fragmentation is related to sperm morphological staining patterns","volume":"31","author":"S\u00e1","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t2019021807303991800_bib164","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10815-014-0370-5","article-title":"DNA fragmentation in human sperm after magnetic-activated cell sorting","volume":"32","author":"Bucar","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib165","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature08162","article-title":"Distinctive chromatin in human sperm packages genes for embryo development","volume":"460","author":"Hammoud","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib166","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1095\/biolreprod63.2.591","article-title":"Telomere length in male germ cells is inversely correlated with telomerase activity","volume":"63","author":"Achi","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib167","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00404-012-2632-8","article-title":"Analysis of sperm telomere length in men with idiopathic infertility","volume":"287","author":"Thilagavathi","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t2019021807303991800_bib168","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s10815-013-9993-1","article-title":"Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss","volume":"30","author":"Thilagavathi","year":"2013","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib169","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.0400755101","article-title":"Irregular telomeres impair meiotic synapsis and recombination in mice","volume":"101","author":"Liu","year":"2004","journal-title":"Proc Natl Acad Sci"},{"key":"key\n\t\t\t\t2019021807303991800_bib170","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1091\/mbc.12.7.2023","article-title":"Telomere dysfunction triggers developmentally regulated germ cell apoptosis","volume":"12","author":"Hemann","year":"2001","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t2019021807303991800_bib171","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrg3245","article-title":"Human aneuploidy: mechanisms and new insights into an age-old problem","volume":"13","author":"Nagaoka","year":"2012","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t2019021807303991800_bib172","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.fertnstert.2014.06.005","article-title":"Telomere homeostasis is compromised in spermatocytes from patients with idiopathic infertility","volume":"102","author":"Reig-Viader","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019021807303991800_bib173","doi-asserted-by":"crossref","first-page":"e0156817","DOI":"10.1371\/journal.pone.0156817","article-title":"Altered crossover distribution and frequency in spermatocytes of infertile men with azoospermia","volume":"11","author":"Ren","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019021807303991800_bib174","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10577-012-9323-y","article-title":"Hierarchical radial and polar organisation of chromosomes in human sperm","volume":"20","author":"Millan","year":"2012","journal-title":"Chromosome Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.gene.2013.11.008","article-title":"Genetic variants in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) and the risk of male infertility","volume":"534","author":"Yan","year":"2014","journal-title":"Gene"},{"key":"key\n\t\t\t\t2019021807303991800_bib176","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/humrep\/17.1.150","article-title":"Quantification of the expression level of the gene encoding the catalytic subunit of telomerase in testicular tissue specimens predicts successful sperm recovery","volume":"17","author":"Schrader","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019021807303991800_bib177","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.rbmo.2015.02.016","article-title":"Processing of semen by density gradient centrifugation selects spermatozoa with longer telomeres for assisted reproduction techniques","volume":"31","author":"Yang","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t2019021807303991800_bib178","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.rbmo.2016.06.006","article-title":"Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality","volume":"33","author":"Cariati","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t2019021807303991800_bib179","doi-asserted-by":"crossref","first-page":"e91753","DOI":"10.1371\/journal.pone.0091753","article-title":"Genomic instability in newborn with short telomeres","volume":"9","author":"Moreno-Palomo","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019021807303991800_bib180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mrfmmm.2010.03.003","article-title":"Swim-up procedure selects spermatozoa with longer telomere length","volume":"688","author":"Santiso","year":"2010","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t2019021807303991800_bib181","doi-asserted-by":"crossref","first-page":"39051","DOI":"10.1038\/srep39051","article-title":"Semen preparation methods and sperm telomere length: Density gradient centrifugation versus the swim up procedure","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019021807303991800_bib182","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/dbio.2002.0735","article-title":"An essential role for functional telomeres in mouse germ cells during fertilization and early development","volume":"249","author":"Liu","year":"2002","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t2019021807303991800_bib183","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/33345","article-title":"Essential role of mouse telomerase in highly proliferative organs","volume":"392","author":"Lee","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019021807303991800_bib184","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/100\/2\/318\/27829534\/ioy215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:14:27Z","timestamp":1720656867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/100\/2\/318\/5114555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":184,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,10,3]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioy215","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,10,3]]}}}