{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:18:53Z","timestamp":1773515933806,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Ministry of Health and the Canadian Institutes of Health Research"},{"name":"Centres of Excellence in Neurodegeneration"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 327387"],"award-info":[{"award-number":["MOP 327387"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC Clinician Scientist Fellowship","award":["MR\/M008525\/1"],"award-info":[{"award-number":["MR\/M008525\/1"]}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rare Disease Translational Research Collaboration","award":["BRC149\/NS\/MH"],"award-info":[{"award-number":["BRC149\/NS\/MH"]}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["MR\/M023664\/1"],"award-info":[{"award-number":["MR\/M023664\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genetic forms of frontotemporal dementia are most commonly due to mutations in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those at risk. While cerebral blood flow shows differences between frontotemporal dementia and other forms of dementia, there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia. This study aimed to delineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a voxel-based approach. In the multicentre GENetic Frontotemporal dementia Initiative (GENFI) study, we investigated cross-sectional differences in arterial spin labelling MRI-based cerebral blood flow between presymptomatic C9orf72, GRN or MAPT mutation carriers (n = 107) and non-carriers (n = 113), using general linear mixed-effects models and voxel-based analyses. Cerebral blood flow within regions of interest derived from this model was then explored to identify differences between individual gene carrier groups and to estimate a timeframe for the expression of these differences. The voxel-based analysis revealed a significant inverse association between cerebral blood flow and the expected age of symptom onset in carriers, but not non-carriers. Regions included the bilateral insulae\/orbitofrontal cortices, anterior cingulate\/paracingulate gyri, and inferior parietal cortices, as well as the left middle temporal gyrus. For all bilateral regions, associations were greater on the right side. After correction for partial volume effects in a region of interest analysis, the results were found to be largely driven by the C9orf72 genetic subgroup. These cerebral blood flow differences first appeared approximately 12.5 years before the expected symptom onset determined on an individual basis. Cerebral blood flow was lower in presymptomatic mutation carriers closer to and beyond their expected age of symptom onset in key frontotemporal dementia signature regions. These results suggest that arterial spin labelling MRI may be a promising non-invasive imaging biomarker for the presymptomatic stages of genetic frontotemporal dementia.<\/jats:p>","DOI":"10.1093\/brain\/awz039","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T04:08:05Z","timestamp":1549166885000},"page":"1108-1120","source":"Crossref","is-referenced-by-count":56,"title":["Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study"],"prefix":"10.1093","volume":"142","author":[{"given":"Henri J M M","family":"Mutsaerts","sequence":"first","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Saira S","family":"Mirza","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Jan","family":"Petr","sequence":"additional","affiliation":[{"name":"PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany"}]},{"given":"David L","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University College London, London, UK"}]},{"given":"David M","family":"Cash","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University College London, London, UK"}]},{"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University College London, London, UK"}]},{"given":"Enrico","family":"de Vita","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University College London, London, UK"}]},{"given":"Arron W S","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Zahra","family":"Shirzadi","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Andrew D","family":"Robertson","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada"},{"name":"Memory Clinic, University Health Network, Toronto, Canada"},{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"}]},{"given":"Sara B","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"},{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"},{"name":"L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, Canada"}]},{"given":"Sandra E","family":"Black","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"},{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"},{"name":"L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, Canada"}]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"},{"name":"Baycrest Centre for Geriatric Care, Toronto, Canada"}]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[{"name":"Memory Clinic, University Health Network, Toronto, Canada"},{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[{"name":"Memory Clinic, University Health Network, Toronto, Canada"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada"}]},{"given":"John","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands"}]},{"suffix":"Jr","given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire (CIME), D\u00e9partement des Sciences Neurologiques, CHU de Qu\u00e9bec, Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Medical and Experimental Sciences, University of Brescia, Brescia, Italy"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Centro Dino Ferrari, Fondazione Ca' Granda IRCCS Ospedale Policlinico, University of Milan, Milan, Italy"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}]},{"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Giovanni B","family":"Frisoni","sequence":"additional","affiliation":[{"name":"IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Neurology Department, Faculty of Medicine of Lisbon, Portugal"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Institute of Neurology, University College London, London, UK"}]},{"given":"Bradley J","family":"MacIntosh","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Canada"},{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"},{"name":"L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, Canada"},{"name":"Cognitive and Movement Disorders Clinic, Sunnybrook Health Sciences Centre, Toronto, Canada"}]},{"name":"GENetic Frontotemporal dementia Initiative (GENFI)","sequence":"additional","affiliation":[]},{"given":"Christin","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Silvana","family":"Archetti","sequence":"additional","affiliation":[{"name":"Biotechnology Laboratory, Department of Diagnostics, Civic Hospital of Brescia, Brescia, Italy"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Physiopathology and Transplantation, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy"}]},{"given":"Luisa","family":"Benussi","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Giuliano","family":"Binetti","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Maura","family":"Cosseddu","sequence":"additional","affiliation":[{"name":"Centre of Brain Aging, University of Brescia, Brescia, Italy"}]},{"given":"Katrina M","family":"Dick","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]},{"given":"Marie","family":"Fallstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden"}]},{"given":"Carlos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Ci\u00eancias Nucleares Aplicadas \u00e0 Sa\u00fade, Universidade de Coimbra, Coimbra, Portugal"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, \u2018Dino Ferrari\u2019 Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}]},{"given":"Nick C","family":"Fox","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]},{"given":"Giorgio","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[{"name":"Centre of Brain Aging, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}]},{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Marina","family":"Grisoli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Lize","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Lize Jiskoot \u2013 Department of Neurology, Erasmus Medical Center, Rotterdam (l.c.jiskoot@erasmusmc.nl)"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[{"name":"Lisbon Faculty of Medicine, Language Research Laboratory, Lisbon, Portugal"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[{"name":"MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK"}]},{"given":"Lieke","family":"Meeter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Linn","family":"\u00d6ijerstedt","sequence":"additional","affiliation":[{"name":"Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Sebastien","family":"Ourselin","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, University College London, UK"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical and Experimental Sciences, University of Brescia, Brescia, Italy"}]},{"given":"Jessica","family":"Panman","sequence":"additional","affiliation":[{"name":"Jessica Panman \u2013 Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands (j.panman@erasmusmc.nl)"}]},{"given":"Michela","family":"Pievani","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathophysiology, University of Florence, Florence, Italy"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[{"name":"Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mayo Clinic, Jacksonville, Florida"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Martin N","family":"Rossor","sequence":"additional","affiliation":[{"name":"Martin N Rossor \u2013 Dementia Research Centre, UCL Institute of Neurology, UK (m.rossor@ucl.ac.uk)"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Physiopathology and Transplantation, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy"}]},{"given":"Hakan","family":"Thonberg","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Santa Maria Hospital, University of Lisbon, Portugal"}]},{"given":"Jason D","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]},{"given":"Christin","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Silvana","family":"Archetti","sequence":"additional","affiliation":[{"name":"Biotechnology Laboratory, Department of Diagnostics, Civic Hospital of Brescia, Brescia, Italy"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Physiopathology and Transplantation, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy"}]},{"given":"Luisa","family":"Benussi","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Giuliano","family":"Binetti","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Maura","family":"Cosseddu","sequence":"additional","affiliation":[{"name":"Centre of Brain Aging, University of Brescia, Brescia, Italy"}]},{"given":"Katrina M","family":"Dick","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]},{"given":"Marie","family":"Fallstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden"}]},{"given":"Carlos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Ci\u00eancias Nucleares Aplicadas \u00e0 Sa\u00fade, Universidade de Coimbra, Coimbra, Portugal"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, \u2018Dino Ferrari\u2019 Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}]},{"given":"Nick C","family":"Fox","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]},{"given":"Giorgio","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[{"name":"Centre of Brain Aging, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}]},{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Marina","family":"Grisoli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Lize","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Lize Jiskoot \u2013 Department of Neurology, Erasmus Medical Center, Rotterdam (l.c.jiskoot@erasmusmc.nl)"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[{"name":"Lisbon Faculty of Medicine, Language Research Laboratory, Lisbon, Portugal"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[{"name":"MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK"}]},{"given":"Lieke","family":"Meeter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy"}]},{"given":"Linn","family":"\u00d6ijerstedt","sequence":"additional","affiliation":[{"name":"Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Sebastien","family":"Ourselin","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, University College London, UK"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical and Experimental Sciences, University of Brescia, Brescia, Italy"}]},{"given":"Jessica","family":"Panman","sequence":"additional","affiliation":[{"name":"Jessica Panman \u2013 Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands (j.panman@erasmusmc.nl)"}]},{"given":"Michela","family":"Pievani","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathophysiology, University of Florence, Florence, Italy"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[{"name":"Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mayo Clinic, Jacksonville, Florida"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Martin N","family":"Rossor","sequence":"additional","affiliation":[{"name":"Martin N Rossor \u2013 Dementia Research Centre, UCL Institute of Neurology, UK (m.rossor@ucl.ac.uk)"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Physiopathology and Transplantation, Fondazione C\u00e0 Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan, Italy"}]},{"given":"Hakan","family":"Thonberg","sequence":"additional","affiliation":[{"name":"Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologico Carlo Besta, Milano, Italy"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Santa Maria Hospital, University of Lisbon, Portugal"}]},{"given":"Jason D","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Institute of Neurology, UK"}]}],"member":"286","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"2020101607143934300_awz039-B1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.2011.06011.x","article-title":"The von Economo neurons in the frontoinsular and anterior cingulate cortex","volume":"1225","author":"Allman","year":"2011","journal-title":"Ann N Y Acad 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