{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:01:24Z","timestamp":1769281284405,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ordem dos Farmac\u00eauticos"},{"name":"Multiple Sclerosis Innovation-Merck Serono to Adelaide Fernandes"},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia to iMed"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Studies have correlated excessive S100B, a small inflammatory molecule, with demyelination and associated inflammatory processes occurring in multiple sclerosis. The relevance of S100B in multiple sclerosis pathology brought an emerging curiosity highlighting its use as a potential therapeutic target to reduce damage during the multiple sclerosis course, namely during inflammatory relapses. We examined the relevance of S100B and further investigated the potential of S100B-neutralizing small-molecule pentamidine in chronic experimental autoimmune encephalomyelitis. S100B depletion had beneficial pathological outcomes and based on promising results of a variety of S100B blockade strategies in an ex vivo demyelinating model, we choose pentamidine to assay its role in the in vivo experimental autoimmune encephalomyelitis. We report that pentamidine prevents more aggressive clinical symptoms and improves recovery of chronic experimental autoimmune encephalomyelitis. Blockade of S100B by pentamidine protects against oligodendrogenesis impairment and neuroinflammation by reducing astrocyte reactivity and microglia pro-inflammatory phenotype. Pentamidine also increased regulatory T cell density in the spinal cord suggesting an additional immunomodulatory action. These results showed the relevance of S100B as a main driver of neuroinflammation in experimental autoimmune encephalomyelitis and identified an uncharacterized mode of action of pentamidine, strengthening the possibility to use this drug as an anti-inflammatory and remyelinating therapy for progressive multiple sclerosis.<\/jats:p>","DOI":"10.1093\/braincomms\/fcac076","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:52:54Z","timestamp":1648158774000},"source":"Crossref","is-referenced-by-count":7,"title":["S100B inhibition protects from chronic experimental autoimmune encephalomyelitis"],"prefix":"10.1093","volume":"4","author":[{"given":"Catarina","family":"Barros","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-9519","authenticated-orcid":false,"given":"Andreia","family":"Barateiro","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]},{"given":"Alexandre","family":"Neto","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]},{"given":"Beatriz","family":"Soromenho","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]},{"given":"Afonso P.","family":"Basto","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"},{"name":"CIISA \u2013 Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa , 1300-477 Lisbon, Portugal"}]},{"given":"Joana M.","family":"Mateus","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"},{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"}]},{"given":"Sara","family":"Xapelli","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"},{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"}]},{"given":"Ana M.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"},{"name":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"}]},{"given":"Dora","family":"Brites","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]},{"given":"Lu\u00eds","family":"Gra\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-9519","authenticated-orcid":false,"given":"Adelaide","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"},{"name":"Department of Pharmaceutical Sciences and Medicines, Faculdade de Farm\u00e1cia, Universidade de Lisboa , 1600-083 Lisbon, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"issue":"9","key":"2022053122261699900_fcac076-B1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.mpmed.2016.06.005","article-title":"Multiple sclerosis","volume":"44","author":"Raffel","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2022053122261699900_fcac076-B2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/B978-0-444-64076-5.00046-6","article-title":"Multiple 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