{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T01:31:30Z","timestamp":1776562290035,"version":"3.51.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":252,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["165981"],"award-info":[{"award-number":["165981"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011021","name":"Sunnybrook Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The thalamus has extensive inter-connectedness with different brain regions in serving cognitive processes. In a community-dwelling aging population from the United Kingdom, this study examined the independent contribution of thalamus volume loss to cognitive performances and the longitudinal anatomical relationship between the thalamus and the interconnected hippocampus. We accessed MRI data from 4348 cognitively unimpaired older adults from the UK Biobank, of whom 653 participants had follow-up MRI. We estimated regional brain volumes using T1-weighted MRI. Linear models tested the association between the thalamus volume and a cognitive composite score derived from digit-symbol substitution and trail-making tests. We used latent change score models to test the longitudinal associations between thalamus volume at baseline and the trajectory of hippocampal atrophy, and vice versa. Baseline thalamus volume was positively associated with the cognitive composite score (\u03b2=0.055\u00b10.018, P = 0.002, R2 = 0.09). A larger baseline thalamus volume predicted slower hippocampal atrophy (\u03b3T\u2192dH=\u22120.048\u00b10.015,P=0.001,R2=0.09), while larger hippocampal volume at baseline predicted faster thalamic atrophy (\u03b3H\u2192dT=0.043\u00b10.022,P=0.048,R2=0.04). Sex-stratified analysis revealed that hippocampal volume significantly predicted thalamic atrophy only in women. This study revealed that thalamic volume loss was associated with impaired processing speed and executive function. Thalamus and hippocampus anatomy showed bidirectional longitudinal associations and demonstrated sex differences. These findings underscore the thalamus anatomy as an important marker of brain health in the aging population.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf334","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T17:30:50Z","timestamp":1757525450000},"source":"Crossref","is-referenced-by-count":1,"title":["Thalamus anatomy predicts cognitive performance and hippocampal atrophy in aging adults: a UK Biobank study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-3172","authenticated-orcid":false,"given":"Guocheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto M5S 1A1 ,","place":["Canada"]},{"name":"Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Program, Sunnybrook Research Institute , Toronto, ON M4N 3M5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-1731","authenticated-orcid":false,"given":"Fa-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto M5S 1A1 ,","place":["Canada"]},{"name":"Physical Sciences Platform, Sunnybrook Research Institute , Toronto M4N 3M5 ,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON M5S 1A1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Cogo-Moreira","sequence":"additional","affiliation":[{"name":"Faculty of Teacher Education and Languages, \u00d8stfold University College , Halden 1757 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-2221","authenticated-orcid":false,"given":"Jennifer S","family":"Rabin","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute , Toronto, Ontario M4N 3M5 ,","place":["Canada"]},{"name":"Department of Psychology, University of Toronto, Toronto , M5S 1A1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Jean","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto M5S 1A1 ,","place":["Canada"]},{"name":"Baycrest Health Sciences, Rotman Research Institute , Toronto M6A 2E1 ,","place":["Canada"]},{"name":"Institute of Biomedical Engineering, Faculty of Applied Science and Engineering, University of Toronto , Toronto M5S 3E3 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Swardfager","sequence":"additional","affiliation":[{"name":"Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Program, Sunnybrook Research Institute , Toronto, ON M4N 3M5 ,","place":["Canada"]},{"name":"Department of Pharmacology and Toxicology, University of Toronto , Toronto, Ontario M5S 1A1 ,","place":["Canada"]},{"name":"KITE Research Institute, University Health Network , Toronto, Ontario M5G 2A2 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley J","family":"MacIntosh","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto , Toronto M5S 1A1 ,","place":["Canada"]},{"name":"Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Program, Sunnybrook Research Institute , Toronto, ON M4N 3M5 ,","place":["Canada"]},{"name":"Physical Sciences Platform, Sunnybrook Research Institute , Toronto M4N 3M5 ,","place":["Canada"]},{"name":"Hurvitz Brain Sciences Program, Sunnybrook Research Institute , Toronto, Ontario M4N 3M5 ,","place":["Canada"]},{"name":"Department of Physics and Computational Radiology, Computational Radiology and Artificial Intelligence Unit, Clinic for Radiology and Nuclear Medicine, Oslo University Hospital , Oslo N-0424 ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"issue":"1","key":"2025092305113288000_fcaf334-B1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1523\/JNEUROSCI.0479-18.2018","article-title":"The cognitive thalamus as a gateway to mental representations","volume":"39","author":"Wolff","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"2025092305113288000_fcaf334-B2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","article-title":"The role of prefrontal cortex in cognitive control and executive 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