{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:14:33Z","timestamp":1761596073508,"version":"build-2065373602"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Radiation Effects Research Foundation"},{"DOI":"10.13039\/501100003478","name":"Japanese Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"US Department of Energy","doi-asserted-by":"publisher","award":["DE-HS0000031"],"award-info":[{"award-number":["DE-HS0000031"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000209","name":"National Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Several decades ago a dramatic leap forward occurred in the development and application of statistical methods for modeling radiation risk at the Radiation Effects Research Foundation (RERF). Poisson regression analysis for grouped person-year cohort data and the linear excess relative risk model were introduced, and subsequently a devoted software system, Epicure\u00ae (https:\/\/www.hirosoft.com), was developed by researchers at RERF and at the U.S. National Cancer Institute. Numerous advancements in understanding radiation effects on humans were made possible with these methods, which are still the state-of-the-art for risk assessment at RERF and have remained part of the standard toolbox for radiation\u2014and other environmental\u2014epidemiological studies worldwide. Nevertheless, as our understanding of radiation risk has increased, so have the breadth and depth of questions that require answers based on emerging data that are not amenable to these conventional methods. This overview briefly recounts the conventional methods and then describes our recent diversification into the use or development of new statistical approaches to meet the challenges of burgeoning biological data and emerging mechanistic information. We briefly discuss the development and application of new methods, current and planned, that are part of the RERF Statistics Department\u2019s role in supporting institution-wide research, especially in our collaborations involving the Life Span Study, Adult Health Study, and First-generation Offspring Clinical Study. Some approaches to modeling and assessing radiation risk with newer methods mentioned herein have already been published, while some are still in development or are only beginning at the proposal stage.<\/jats:p>","DOI":"10.1093\/carcin\/bgaf043","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:31:21Z","timestamp":1755603081000},"source":"Crossref","is-referenced-by-count":2,"title":["Recent evolution of risk analyses in atomic bomb survivor studies: new methods and applications"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-6639","authenticated-orcid":false,"given":"John","family":"Cologne","sequence":"first","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-4880","authenticated-orcid":false,"given":"Munechika","family":"Misumi","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-6490","authenticated-orcid":false,"given":"Hanna","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-9151","authenticated-orcid":false,"given":"Zhenqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-2360","authenticated-orcid":false,"given":"Richard","family":"Sposto","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"2025102711490659100_bgaf043-B1","volume-title":"Modern Statistical Methods in Chronic Disease Epidemiology","author":"Moolgavkar","year":"1986"},{"key":"2025102711490659100_bgaf043-B2","volume-title":"Statistical Methods in Cancer Research: Volume II (The Design and Analysis of Cohort Studies","author":"Breslow","year":"1987"},{"key":"2025102711490659100_bgaf043-B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-9218-7","volume-title":"Scientific Issues in Quantitative Cancer Risk Assessment","author":"Moolgavkar","year":"1990"},{"key":"2025102711490659100_bgaf043-B4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2307\/3575716","article-title":"Studies of the mortality of A-bomb survivors 7. 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