{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:49:27Z","timestamp":1792806567138,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024584","name":"DOE","doi-asserted-by":"publisher","award":["DE-HS0000031"],"award-info":[{"award-number":["DE-HS0000031"]}],"id":[{"id":"10.13039\/100024584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000209","name":"National Academy of Sciences","doi-asserted-by":"publisher","award":["HHSN261201400009C"],"award-info":[{"award-number":["HHSN261201400009C"]}],"id":[{"id":"10.13039\/100000209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021671","name":"U.S. National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCI Intramural Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This paper concludes the third comprehensive report on radiation effects on solid cancer incidence within the Life Span Study (LSS) cohort of Japanese atomic bomb survivors, adding 11 years of follow-up. Over 1958\u20132009, 22 538 solid cancer cases and 3.1 million person-years were identified among 105 444 individuals. The study utilized improved radiation doses (DS02R1), updated migration probabilities, and adjustments for smoking and lifestyle factors. Poisson regression was used to model excess relative risk (ERR) and excess absolute rate (EAR) per 1\u2005Gy for all-solid cancers combined and specific sites. Among females, a linear dose\u2013response model best described all-solid cancer risk [ERR = 0.64\u2005Gy\u22121, 95% confidence interval (CI): 0.52\u20130.77], whereas among males, a linear-quadratic model with upward curvature provided the best fit (ERR = 0.20 at 1\u2005Gy, 95% CI: 0.12\u20130.28). Radiation-associated ERR declined with attained age, more rapidly in males than in females, while EAR increased with age. Independently, radiation-associated ERR and EAR decreased with age at exposure. A significant dose\u2013response was identified for prostate cancer for the first time; for brain and central nervous system tumors, female pancreatic, and uterine corpus cancers dose\u2013response reached statistical significance. A new age-at-exposure pattern emerged for female breast and uterine corpus cancers, suggesting that radiation-associated risk increased as exposure age approached menarche (\u223cage 15), decreasing at older exposure ages. Most cancers exhibited linear dose\u2013response, except non-melanoma skin, bone and joint, esophageal, and kidney parenchyma cancers in males. Sixty-four years post-exposure, solid cancer risks remain elevated, reinforcing the LSS's critical role in unraveling lifetime cancer effects of a-bomb radiation after exposure at various ages.<\/jats:p>","DOI":"10.1093\/carcin\/bgaf060","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:45:51Z","timestamp":1758023151000},"source":"Crossref","is-referenced-by-count":9,"title":["Summary of radiation effects on incidence of solid cancers in the Life Span Study of atomic bomb survivors: 1958\u20132009"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-3907","authenticated-orcid":false,"given":"Alina V","family":"Brenner","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-0865","authenticated-orcid":false,"given":"Hiromi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-6639","authenticated-orcid":false,"given":"John","family":"Cologne","sequence":"additional","affiliation":[{"name":"Department of Statistics, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-5502","authenticated-orcid":false,"given":"Ritsu","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-3252","authenticated-orcid":false,"given":"Mai","family":"Utada","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-8329","authenticated-orcid":false,"given":"Eric J","family":"Grant","sequence":"additional","affiliation":[{"name":"Hirosoft International LLC , Eureka, CA 95501 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-5378","authenticated-orcid":false,"given":"Benjamin","family":"French","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University , Nashville, TN 37203 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-0588","authenticated-orcid":false,"given":"Elizabeth K","family":"Cahoon","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD 20892 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-2925","authenticated-orcid":false,"given":"Dale L","family":"Preston","sequence":"additional","affiliation":[{"name":"Hirosoft International LLC , Eureka, CA 95501 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-1383","authenticated-orcid":false,"given":"Kotaro","family":"Ozasa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation , Hiroshima 732-0815 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-8777","authenticated-orcid":false,"given":"Kiyohiko","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, MD 20892 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"2025102711522016100_bgaf060-B1","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.2307\/3578892","article-title":"Cancer incidence in atomic bomb survivors. Part II: solid tumors, 1958\u20131987","volume":"137","author":"Thompson","year":"1994","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1667\/Rr0763.1","article-title":"Solid cancer incidence in atomic bomb survivors: 1958\u20131998","volume":"168","author":"Preston","year":"2007","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1667\/Rr14492.1","article-title":"Solid cancer incidence among the Life Span Study of atomic bomb survivors: 1958\u20132009","volume":"187","author":"Grant","year":"2017","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B4","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1667\/Rr15386.1","article-title":"Radiation-related risk of cancers of the upper digestive tract among Japanese atomic bomb survivors","volume":"192","author":"Sakata","year":"2019","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B5","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/Ijc.32275","article-title":"Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958\u20132009","volume":"146","author":"Sugiyama","year":"2020","journal-title":"Int J Cancer"},{"key":"2025102711522016100_bgaf060-B6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1667\/Rr15341.1","article-title":"Radiation and risk of liver, biliary tract, and pancreatic cancers among atomic bomb survivors in Hiroshima and Nagasaki: 1958\u20132009","volume":"192","author":"Sadakane","year":"2019","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B7","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1667\/Rr14583.1","article-title":"Lung, laryngeal and other respiratory cancer incidence among Japanese atomic bomb survivors: an updated analysis from 1958 through 2009","volume":"187","author":"Cahoon","year":"2017","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1667\/Rade-20-00158.1","article-title":"Radiation risks for the incidence of kidney, bladder and other urinary tract cancers: 1958\u20132009","volume":"195","author":"Grant","year":"2021","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1667\/Rr15015.1","article-title":"Incidence of breast cancer in the Life Span Study of atomic bomb survivors: 1958\u20132009","volume":"190","author":"Brenner","year":"2018","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/S10654-019-00599-Y","article-title":"Radiation risk of central nervous system tumors in the Life Span Study of atomic bomb survivors, 1958\u20132009","volume":"35","author":"Brenner","year":"2020","journal-title":"Eur J Epidemiol"},{"key":"2025102711522016100_bgaf060-B11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1667\/Rr15481.1","article-title":"Risk of prostate cancer incidence among atomic bomb survivors: 1958\u20132009","volume":"195","author":"Mabuchi","year":"2021","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1667\/Rade-20-00170.1","article-title":"Radiation risk of ovarian cancer in atomic bomb survivors: 1958\u20132009","volume":"195","author":"Utada","year":"2021","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1667\/Rade-22-00089.1","article-title":"The effect of prostate-specific antigen (PSA) test on radiation risk estimate for prostate cancer incidence among atomic-bomb survivors","volume":"200","author":"Utada","year":"2023","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B14","doi-asserted-by":"publisher","first-page":"Pky081","DOI":"10.1093\/Jncics\/Pky081","article-title":"Radiation risks of uterine cancer in atomic bomb survivors: 1958\u20132009","volume":"2","author":"Utada","year":"2018","journal-title":"JNCI Cancer Spectr"},{"key":"2025102711522016100_bgaf060-B15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/Hp.0000000000000598","article-title":"DS02R1: improvements to atomic bomb survivors\u2019 input data and implementation of dosimetry system 2002 (Ds02) and resulting changes in estimated doses","volume":"112","author":"Cullings","year":"2017","journal-title":"Health Phys"},{"key":"2025102711522016100_bgaf060-B16","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/S10654-017-0337-9","article-title":"Selection of reference groups in the Life Span Study of atomic bomb survivors","volume":"32","author":"French","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"2025102711522016100_bgaf060-B17","first-page":"Viii, 242","volume-title":"International Classification of Diseases for Oncology: ICD-O","author":"Fritz","year":"2013","edition":"3rd edn"},{"key":"2025102711522016100_bgaf060-B18","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"World Health Organization","year":"2004","edition":"2nd edn"},{"key":"2025102711522016100_bgaf060-B19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1667\/Rr3546.1","article-title":"Dose estimation for atomic bomb survivor studies: its evolution and present status","volume":"166","author":"Cullings","year":"2006","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2307\/3577733","article-title":"Allowing for random errors in radiation dose estimates for the atomic bomb survivor data","volume":"123","author":"Pierce","year":"1990","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1667\/Rr2083.1","article-title":"Radiation and smoking effects on lung cancer incidence among atomic bomb survivors","volume":"174","author":"Furukawa","year":"2010","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2307\/3578452","article-title":"Joint analysis of site-specific cancer risks for the atomic bomb survivors","volume":"134","author":"Pierce","year":"1993","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B23","volume-title":"Epicure Risk Regression and Person-Year Computation Software: Command Summary and User Guide","author":"Preston","year":"2015"},{"key":"2025102711522016100_bgaf060-B24","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1667\/Rr15127.1","article-title":"Effect of heterogeneity in background incidence on inference about the solid-cancer radiation dose response in atomic bomb survivors","volume":"192","author":"Cologne","year":"2019","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B25","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1667\/Rade-21-00059.1","article-title":"Comparison of all solid cancer mortality and incidence dose-response in the Life Span Study of atomic bomb survivors, 1958\u20132009","volume":"197","author":"Brenner","year":"2022","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B26","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/jnci\/94.20.1555","article-title":"Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure","volume":"94","author":"Preston","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"2025102711522016100_bgaf060-B27","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/J.Fertnstert.2015.04.042","article-title":"Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound (3-dimensional) and magnetic resonance imaging","volume":"104","author":"Hagen","year":"2015","journal-title":"Fertil Steril"},{"key":"2025102711522016100_bgaf060-B28","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1023\/A:1026487120779","article-title":"Human breast development","volume":"5","author":"Howard","year":"2000","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2025102711522016100_bgaf060-B29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/0146645315595585","article-title":"ICRP publication 131: stem cell biology with respect to carcinogenesis aspects of radiological protection","volume":"44","author":"Niwa","year":"2015","journal-title":"Ann ICRP"},{"key":"2025102711522016100_bgaf060-B30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/S10911-013-9272-X","article-title":"New biological insights on the link between radiation exposure and breast cancer risk","volume":"18","author":"Barcellos-Hoff","year":"2013","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2025102711522016100_bgaf060-B31","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1667\/Rr13494.1","article-title":"Skin cancer incidence among atomic bomb survivors from 1958 to 1996","volume":"181","author":"Sugiyama","year":"2014","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B32","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.2106\/Jbjs.J.00256","article-title":"Exposure to ionizing radiation and development of bone sarcoma: new insights based on atomic-bomb survivors of Hiroshima and Nagasaki","volume":"93","author":"Samartzis","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"2025102711522016100_bgaf060-B33","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1002\/Ijc.27749","article-title":"Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure","volume":"132","author":"Furukawa","year":"2013","journal-title":"Int J Cancer"},{"key":"2025102711522016100_bgaf060-B34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1667\/Rr1092.1","article-title":"Improved estimates of cancer site-specific risks for A-bomb survivors","volume":"169","author":"Pawel","year":"2008","journal-title":"Radiat Res"},{"key":"2025102711522016100_bgaf060-B35","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaf043","article-title":"Recent evolution of risk analyses in atomic-bomb survivor studies: new methods and applications","volume":"46","author":"Cologne","year":"2025","journal-title":"Carcinogenesis"},{"key":"2025102711522016100_bgaf060-B36","author":"United Nations Scientific Committee on the Effects of Atomic Radiation"},{"key":"2025102711522016100_bgaf060-B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/01466453221080101","article-title":"ICRP publication 152 approved by the commission in November 2021","volume":"51","year":"2022","journal-title":"Ann ICRP"},{"key":"2025102711522016100_bgaf060-B38","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4054\/DemRes.2002.7.5","article-title":"The cancer transition in Japan since 1951","volume":"7","author":"Gersten","year":"2002","journal-title":"Demogr Res"},{"key":"2025102711522016100_bgaf060-B39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/Caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2025102711522016100_bgaf060-B40","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/S13073-020-00744-3","article-title":"Ancestry-specific predisposing germline variants in cancer","volume":"12","author":"Oak","year":"2020","journal-title":"Genome Med"},{"key":"2025102711522016100_bgaf060-B41","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1038\/S41588-024-01913-5","article-title":"Population-specific putative causal variants shape quantitative traits","volume":"56","author":"Koyama","year":"2024","journal-title":"Nat Genet"},{"key":"2025102711522016100_bgaf060-B42","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.3748\/Wjg.V28.I12.1187","article-title":"Epidemiology of stomach cancer","volume":"28","author":"Ilic","year":"2022","journal-title":"World J Gastroenterol"},{"key":"2025102711522016100_bgaf060-B43","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/Ijc.30211","article-title":"International trends in liver cancer incidence, overall and by histologic subtype, 1978\u20132007","volume":"139","author":"Petrick","year":"2016","journal-title":"Int J Cancer"},{"key":"2025102711522016100_bgaf060-B44","doi-asserted-by":"publisher","first-page":"E0221775","DOI":"10.1371\/Journal.Pone.0221775","article-title":"Global incidence of prostate cancer in developing and developed countries with changing age structures","volume":"14","author":"Teoh","year":"2019","journal-title":"PLoS One"},{"key":"2025102711522016100_bgaf060-B45","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1111\/J.1349-7006.2011.01996.X","article-title":"Risk factors for breast cancer: epidemiological evidence from Japanese studies","volume":"102","author":"Iwasaki","year":"2011","journal-title":"Cancer Sci"},{"key":"2025102711522016100_bgaf060-B46","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1093\/Jjco\/Hyv002","article-title":"An updated report on the trends in cancer incidence and mortality in Japan, 1958\u20132013","volume":"45","author":"Katanoda","year":"2015","journal-title":"Jpn J Clin Oncol"},{"key":"2025102711522016100_bgaf060-B47","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/S00411-020-00837-Y","article-title":"Individual response of humans to ionising radiation: governing factors and importance for radiological protection","volume":"59","author":"Applegate","year":"2020","journal-title":"Radiat Environ Biophys"},{"key":"2025102711522016100_bgaf060-B48","author":"National Council on Radiation Protection and Measurements"},{"key":"2025102711522016100_bgaf060-B49","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1093\/Jnci\/Djaf064","article-title":"Sex-specific radiation-associated lung cancer mortality risks as impacted by smoking among US radiologic technologists","volume":"117","author":"Milder","year":"2025","journal-title":"J Natl Cancer Inst"},{"key":"2025102711522016100_bgaf060-B50","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1080\/09553002.2019.1569778","article-title":"Epidemiological studies of atomic bomb radiation at the radiation effects research foundation","volume":"95","author":"Ozasa","year":"2019","journal-title":"Int J Radiat Biol"},{"key":"2025102711522016100_bgaf060-B51","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaf045","article-title":"History and current developments of RERF dosimetry","author":"Cullings","year":"2025","journal-title":"Carcinogenesis"},{"key":"2025102711522016100_bgaf060-B52","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1667\/Rr15267.1","article-title":"Dosimetric impact of a new computational voxel phantom series for the Japanese atomic bomb survivors: children and adults","volume":"191","author":"Griffin","year":"2019","journal-title":"Radiat Res"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/3\/bgaf060\/64957355\/bgaf060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/carcin\/article-pdf\/46\/3\/bgaf060\/64957355\/bgaf060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:52:28Z","timestamp":1761580348000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/doi\/10.1093\/carcin\/bgaf060\/8304045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9,4]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgaf060","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9]]},"article-number":"bgaf060"}}