{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:03:14Z","timestamp":1784901794084,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Given the rising demand for cosmetic botulinum toxin (BoNT) procedures in the UK, the potential for adverse outcomes and a notable gap in evidence regarding how injector type, treatment location and product choice influence risk, this study aims to investigate these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the relationships between BoNT type, administer and location with odds of adverse events in a large UK patient sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional observational survey was designed to gather data on individuals\u2019 (aged \u2265 18\u2005years) experiences and adverse events (AEs) with cosmetic BoNT injections across the UK. Data were collected on participants' age, sex, injector role, treatment location, BoNT type, AEs and satisfaction. Binary logistic regression models were fitted for each AE to examine the association between the occurrence of the symptom (yes\/no) and injector role, treatment location and BoNT type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 919 participants. Receiving BoNT injections from a beautician was associated significantly with increased odds of some AEs, including pain and eyelid ptosis. Interestingly, BoNT administered by pharmacists was significantly associated with bruising and swelling, whereas BoNT administered by a doctor was associated with increased odds of nerve damage. Medical clinics outperformed all other environments, with patients reporting lower odds of complications across multiple AEs. By contrast, home-based injections carried significantly elevated odds of bruising and swelling. Participants reported unknown or undisclosed BoNT type A products had markedly poorer outcomes across multiple AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings from this cross-sectional study suggest that injectors operating from informal settings, particularly without disclosing the product used, pose a potential measurable and preventable risk. As public demand grows, safeguarding patient outcomes requires further legislative action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag124","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:35:49Z","timestamp":1773491749000},"page":"1427-1432","source":"Crossref","is-referenced-by-count":1,"title":["Relationships between botulinum toxin type, administer and location with odds of adverse events"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9833","authenticated-orcid":false,"given":"Lee","family":"Smith","sequence":"first","affiliation":[{"name":"Centre for Health, Performance and Wellbeing, Anglia Ruskin University , Cambridge ,","place":["UK"]},{"name":"Faculty of Medicine, Department of Public Health, Biruni University , Istanbul 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