{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:00:15Z","timestamp":1777039215123,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Centro 2020 Regional Operational Programme","award":["CENTRO-01-0145-FEDER-000008:BrainHealth 2020"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000008:BrainHealth 2020"]}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-PTDC\/SAU-NMC\/4888\/2014"],"award-info":[{"award-number":["POCI-01-0145-FEDER-PTDC\/SAU-NMC\/4888\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Science and Technology Foundation","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER- 29452"],"award-info":[{"award-number":["POCI-01-0145-FEDER- 29452"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006129","name":"Fuel Cycle Technologies","doi-asserted-by":"publisher","award":["SFRH\/BD\/51682\/2011"],"award-info":[{"award-number":["SFRH\/BD\/51682\/2011"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neuropsychiatric disorders share susceptibility genes, suggesting a common origin. One such gene is CNTNAP2 encoding contactin-associated protein 2 (CASPR2), which harbours mutations associated to autism, schizophrenia, and intellectual disability. Antibodies targeting CASPR2 have also been recently described in patients with several neurological disorders, such as neuromyotonia, Morvan\u2019s syndrome, and limbic encephalitis. Despite the clear implication of CNTNAP2 and CASPR2 in neuropsychiatric disorders, the pathogenic mechanisms associated with alterations in CASPR2 function are unknown. Here, we show that Caspr2 is expressed in excitatory synapses in the cortex, and that silencing its expression in vitro or in vivo decreases the synaptic expression of \u03b1-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and the amplitude of AMPA receptor-mediated currents. Furthermore, Caspr2 loss of function blocks synaptic scaling in vitro and experience-dependent homoeostatic synaptic plasticity in the visual cortex. Patient CASPR2 antibodies decrease the dendritic levels of Caspr2 and synaptic AMPA receptor trafficking, and perturb excitatory transmission in the visual cortex. These results suggest that mutations in CNTNAP2 may contribute to alterations in AMPA receptor function and homoeostatic plasticity, and indicate that antibodies from anti-CASPR2 encephalitis patients affect cortical excitatory transmission.<\/jats:p>","DOI":"10.1093\/cercor\/bhz032","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T12:09:34Z","timestamp":1549627774000},"page":"4919-4931","source":"Crossref","is-referenced-by-count":56,"title":["Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2"],"prefix":"10.1093","volume":"29","author":[{"given":"Dominique","family":"Fernandes","sequence":"first","affiliation":[{"name":"Synapse Biology Group, CNC\u2014Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"PDBEB, Doctoral Programme in Experimental Biology and Biomedicine, CNC & Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3004-504 Coimbra, Portugal"},{"name":"Solomon Snyder Department of Neurosciences, Zanvyl Krieger Mind\/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA"}]},{"given":"Sandra D","family":"Santos","sequence":"additional","affiliation":[{"name":"Synapse Biology Group, CNC\u2014Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Ester","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK"}]},{"given":"Jessica L","family":"Whitt","sequence":"additional","affiliation":[{"name":"Solomon Snyder Department of Neurosciences, Zanvyl Krieger Mind\/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA"}]},{"given":"Nuno","family":"Beltr\u00e3o","sequence":"additional","affiliation":[{"name":"Synapse Biology Group, CNC\u2014Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Tiago","family":"Rond\u00e3o","sequence":"additional","affiliation":[{"name":"Synapse Biology Group, CNC\u2014Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"M Isabel","family":"Leite","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK"}]},{"given":"Camilla","family":"Buckley","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK"}]},{"given":"Hey-Kyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Solomon Snyder Department of Neurosciences, Zanvyl Krieger Mind\/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-6666","authenticated-orcid":false,"given":"Ana Lu\u00edsa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Synapse Biology Group, CNC\u2014Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, 3004-504 Coimbra, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"issue":"1","key":"2021031700100753300_bhz032C1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2007.09.005","article-title":"Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene","volume":"82","author":"Alarcon","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"44","key":"2021031700100753300_bhz032C2","doi-asserted-by":"crossref","first-page":"18120","DOI":"10.1073\/pnas.1216398109","article-title":"Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development","volume":"109","author":"Anderson","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2021031700100753300_bhz032C3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajhg.2007.09.015","article-title":"A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism","volume":"82","author":"Arking","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2021031700100753300_bhz032C4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ajhg.2007.09.017","article-title":"Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders","volume":"82","author":"Bakkaloglu","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"3","key":"2021031700100753300_bhz032C5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/WCO.0000000000000444","article-title":"Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies)","volume":"30","author":"Bastiaansen","year":"2017","journal-title":"Curr Opin Neurol"},{"issue":"6","key":"2021031700100753300_bhz032C6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.ejhg.5201824","article-title":"Disruption of the CNTNAP2 gene in a t(7;15) translocation family without symptoms of Gilles de la Tourette syndrome","volume":"15","author":"Belloso","year":"2007","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"2021031700100753300_bhz032C7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/ene.13180","article-title":"Anti-contactin-associated protein-2 encephalitis: relevance of antibody presentation and outcome","volume":"24","author":"Bien","year":"2017","journal-title":"Eur J Neurol"},{"issue":"5","key":"2021031700100753300_bhz032C8","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0162-17.2017","article-title":"Developmental disruption of GABAAR-meditated inhibition in Cntnap2 KO mice","volume":"4","author":"Bridi","year":"2017","journal-title":"eNeuro"},{"issue":"12","key":"2021031700100753300_bhz032C9","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/mp.2016.165","article-title":"Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice","volume":"21","author":"Brimberg","year":"2016","journal-title":"Mol Psychiatry"},{"key":"2021031700100753300_bhz032C10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.conb.2017.03.016","article-title":"Sleep, synaptic homeostasis and neuronal firing rates","volume":"44","author":"Cirelli","year":"2017","journal-title":"Curr Opin Neurobiol"},{"issue":"9","key":"2021031700100753300_bhz032C11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/jnnp-2016-315251","article-title":"CASPR2 autoantibodies are raised during pregnancy in mothers of children with mental retardation and disorders of psychological development but not autism","volume":"88","author":"Coutinho","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2021031700100753300_bhz032C12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00401-017-1751-5","article-title":"Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero","volume":"134","author":"Coutinho","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"4","key":"2021031700100753300_bhz032C13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.neuron.2018.01.033","article-title":"Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability","volume":"97","author":"Dawes","year":"2018","journal-title":"Neuron"},{"issue":"6324","key":"2021031700100753300_bhz032C14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1126\/science.aah5982","article-title":"Ultrastructural evidence for synaptic scaling across the wake\/sleep cycle","volume":"355","author":"de Vivo","year":"2017","journal-title":"Science"},{"issue":"6324","key":"2021031700100753300_bhz032C15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1126\/science.aai8355","article-title":"Homer1a drives homeostatic scaling-down of excitatory synapses during sleep","volume":"355","author":"Diering","year":"2017","journal-title":"Science"},{"issue":"6","key":"2021031700100753300_bhz032C16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/jnc.13687","article-title":"Mechanisms of homeostatic plasticity in the excitatory synapse","volume":"139","author":"Fernandes","year":"2016","journal-title":"J Neurochem"},{"issue":"3","key":"2021031700100753300_bhz032C17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.mp.4002049","article-title":"CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy","volume":"13","author":"Friedman","year":"2008","journal-title":"Mol Psychiatry"},{"issue":"5","key":"2021031700100753300_bhz032C18","doi-asserted-by":"crossref","first-page":"e0125633","DOI":"10.1371\/journal.pone.0125633","article-title":"The autism related protein contactin-associated protein-like 2 (CNTNAP2) stabilizes new spines: an in vivo mouse study","volume":"10","author":"Gdalyahu","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"2021031700100753300_bhz032C19","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nn1725","article-title":"Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience","volume":"9","author":"Goel","year":"2006","journal-title":"Nat Neurosci"},{"issue":"25","key":"2021031700100753300_bhz032C20","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1523\/JNEUROSCI.5038-06.2007","article-title":"Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex","volume":"27","author":"Goel","year":"2007","journal-title":"J Neurosci"},{"issue":"3","key":"2021031700100753300_bhz032C21","doi-asserted-by":"crossref","first-page":"e18264","DOI":"10.1371\/journal.pone.0018264","article-title":"Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity","volume":"6","author":"Goel","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"2021031700100753300_bhz032C22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cell.2016.01.046","article-title":"Neuronal firing rate homeostasis is inhibited by sleep and promoted by wake","volume":"165","author":"Hengen","year":"2016","journal-title":"Cell"},{"issue":"4","key":"2021031700100753300_bhz032C23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuron.2015.12.039","article-title":"Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene, CNTNAP2","volume":"89","author":"Hoffman","year":"2016","journal-title":"Neuron"},{"issue":"9","key":"2021031700100753300_bhz032C24","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awq213","article-title":"Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan\u2019s syndrome and acquired neuromyotonia","volume":"133","author":"Irani","year":"2010","journal-title":"Brain"},{"issue":"9","key":"2021031700100753300_bhz032C25","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/jamaneurol.2016.1585","article-title":"Characterization of a subtype of autoimmune encephalitis with anti-contactin-associated protein-like 2 antibodies in the cerebrospinal fluid, prominent limbic symptoms, and seizures","volume":"73","author":"Joubert","year":"2016","journal-title":"JAMA Neurol"},{"issue":"3","key":"2021031700100753300_bhz032C26","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nn1189","article-title":"Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors","volume":"7","author":"Ju","year":"2004","journal-title":"Nat Neurosci"},{"issue":"43","key":"2021031700100753300_bhz032C27","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1523\/JNEUROSCI.1666-15.2015","article-title":"Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2","volume":"35","author":"Jurgensen","year":"2015","journal-title":"J Neurosci"},{"issue":"2","key":"2021031700100753300_bhz032C28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1001\/jamaneurol.2013.592","article-title":"Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping","volume":"70","author":"Klein","year":"2013","journal-title":"JAMA Neurol"},{"issue":"2","key":"2021031700100753300_bhz032C29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.22297","article-title":"Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia","volume":"69","author":"Lancaster","year":"2011","journal-title":"Ann Neurol"},{"key":"2021031700100753300_bhz032C30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nbd.2014.01.019","article-title":"GABA(A) receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia","volume":"65","author":"Mele","year":"2014","journal-title":"Neurobiol Dis"},{"issue":"6","key":"2021031700100753300_bhz032C31","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2016.02.017","article-title":"Unifying views of autism spectrum disorders: a consideration of autoregulatory feedback loops","volume":"89","author":"Mullins","year":"2016","journal-title":"Neuron"},{"issue":"3","key":"2021031700100753300_bhz032C32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/mp.2010.7","article-title":"Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility","volume":"16","author":"O\u2019Dushlaine","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2021031700100753300_bhz032C33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ana.25120","article-title":"Mechanisms of Caspr2 antibodies in autoimmune encephalitis and neuromyotonia","volume":"83","author":"Patterson","year":"2018","journal-title":"Ann Neurol"},{"issue":"1","key":"2021031700100753300_bhz032C34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","article-title":"Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits","volume":"147","author":"Penagarikano","year":"2011","journal-title":"Cell"},{"issue":"3","key":"2021031700100753300_bhz032C35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molmed.2012.01.003","article-title":"What does CNTNAP2 reveal about autism spectrum disorder?","volume":"18","author":"Penagarikano","year":"2012","journal-title":"Trends Mol Med"},{"issue":"23","key":"2021031700100753300_bhz032C36","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1523\/JNEUROSCI.4975-14.2015","article-title":"Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices","volume":"35","author":"Petrus","year":"2015","journal-title":"J Neurosci"},{"issue":"4","key":"2021031700100753300_bhz032C37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0896-6273(00)81049-1","article-title":"Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels","volume":"24","author":"Poliak","year":"1999","journal-title":"Neuron"},{"issue":"3","key":"2021031700100753300_bhz032C38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000456021","article-title":"Intragenic CNTNAP2 deletions: a bridge too far?","volume":"8","author":"Poot","year":"2017","journal-title":"Mol Syndromol"},{"issue":"7215","key":"2021031700100753300_bhz032C39","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/nature07457","article-title":"Failure of neuronal homeostasis results in common neuropsychiatric phenotypes","volume":"455","author":"Ramocki","year":"2008","journal-title":"Nature"},{"issue":"2","key":"2021031700100753300_bhz032C40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ejhg.2013.100","article-title":"Shining a light on CNTNAP2: complex functions to complex disorders","volume":"22","author":"Rodenas-Cuadrado","year":"2014","journal-title":"Eur J Hum Genet"},{"issue":"9","key":"2021031700100753300_bhz032C41","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1074\/jbc.M111.322909","article-title":"Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors","volume":"287","author":"Santos","year":"2012","journal-title":"J Biol Chem"},{"issue":"2","key":"2021031700100753300_bhz032C42","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/cercor\/bhx341","article-title":"Loss of Cntnap2 causes axonal excitability deficits, developmental delay in cortical myelination, and abnormal stereotyped motor behavior","volume":"29","author":"Scott","year":"2017","journal-title":"Cereb Cortex"},{"key":"2021031700100753300_bhz032C43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1146\/annurev.cellbio.23.090506.123516","article-title":"The cell biology of synaptic plasticity: AMPA receptor trafficking","volume":"23","author":"Shepherd","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"12","key":"2021031700100753300_bhz032C44","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/jmedgenet-2016-103880","article-title":"Eight further individuals with intellectual disability and epilepsy carrying bi-allelic CNTNAP2 aberrations allow delineation of the mutational and phenotypic spectrum","volume":"53","author":"Smogavec","year":"2016","journal-title":"J Med Genet"},{"issue":"4","key":"2021031700100753300_bhz032C45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1176\/jnp.23.4.jnp425","article-title":"Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity","volume":"23","author":"Somers","year":"2011","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"13","key":"2021031700100753300_bhz032C46","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMoa052773","article-title":"Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2","volume":"354","author":"Strauss","year":"2006","journal-title":"N Engl J Med"},{"key":"2021031700100753300_bhz032C47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2015.03.005","article-title":"Clinical manifestations of patients with CASPR2 antibodies","volume":"281","author":"Sunwoo","year":"2015","journal-title":"J Neuroimmunol"},{"issue":"3","key":"2021031700100753300_bhz032C48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2008.10.008","article-title":"The self-tuning neuron: synaptic scaling of excitatory synapses","volume":"135","author":"Turrigiano","year":"2008","journal-title":"Cell"},{"issue":"5","key":"2021031700100753300_bhz032C49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1212\/WNL.0000000000002917","article-title":"The clinical spectrum of Caspr2 antibody-associated disease","volume":"87","author":"van Sonderen","year":"2016","journal-title":"Neurology"},{"issue":"5","key":"2021031700100753300_bhz032C50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nrneurol.2017.43","article-title":"The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis","volume":"13","author":"van Sonderen","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"19","key":"2021031700100753300_bhz032C51","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1073\/pnas.1423205112","article-title":"Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2\/Caspr2 knockout neurons","volume":"112","author":"Varea","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2021031700100753300_bhz032C52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0888-7543(03)00097-1","article-title":"CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder","volume":"82","author":"Verkerk","year":"2003","journal-title":"Genomics"},{"issue":"22","key":"2021031700100753300_bhz032C53","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1056\/NEJMoa0802828","article-title":"A functional genetic link between distinct developmental language disorders","volume":"359","author":"Vernes","year":"2008","journal-title":"N Engl J Med"},{"issue":"11","key":"2021031700100753300_bhz032C54","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1093\/cercor\/bhx248","article-title":"Mouse Cntnap2 and human CNTNAP2 ASD alleles cell autonomously regulate PV+ cortical interneurons","volume":"28","author":"Vogt","year":"2018","journal-title":"Cereb Cortex"},{"key":"2021031700100753300_bhz032C55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuropharm.2013.02.016","article-title":"Experience-dependent homeostatic synaptic plasticity in neocortex","volume":"78","author":"Whitt","year":"2014","journal-title":"Neuropharmacology"},{"issue":"11","key":"2021031700100753300_bhz032C56","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1523\/JNEUROSCI.5217-04.2005","article-title":"Postsynaptic expression of homeostatic plasticity at neocortical synapses","volume":"25","author":"Wierenga","year":"2005","journal-title":"J Neurosci"},{"key":"2021031700100753300_bhz032C57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fncel.2013.00223","article-title":"Emerging links between homeostatic synaptic plasticity and neurological disease","volume":"7","author":"Wondolowski","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"2021031700100753300_bhz032C58","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ajhg.2009.10.004","article-title":"CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila","volume":"85","author":"Zweier","year":"2009","journal-title":"Am J Hum Genet"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/29\/12\/4919\/36604849\/bhz032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/29\/12\/4919\/36604849\/bhz032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:18:34Z","timestamp":1615940314000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/29\/12\/4919\/5370683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,4]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,3,4]]},"published-print":{"date-parts":[[2019,12,17]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhz032","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,3,4]]}}}