{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:31:56Z","timestamp":1775550716415,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,7]]},"DOI":"10.1093\/cjres\/rsy009","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T20:11:48Z","timestamp":1521231108000},"page":"275-295","source":"Crossref","is-referenced-by-count":70,"title":["Biotech by bricolage? Agency, institutional relatedness and new path development in peripheral regions"],"prefix":"10.1093","volume":"11","author":[{"given":"Lu\u00eds","family":"Carvalho","sequence":"first","affiliation":[{"name":"Centre of Studies in Geography and Spatial Planning (CEGOT), University of Porto, Via Panor\u00e2mica, s\/n, Porto, Portugal"},{"name":"Centre of Applied Research in Economics & Business (CAREM), Amsterdam University of Applied Sciences"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-2459","authenticated-orcid":false,"given":"M\u00e1rio","family":"Vale","sequence":"additional","affiliation":[{"name":"Centre of Geographical Studies (CEG), Institute of Geography and Spatial Planning (IGOT), University of Lisbon, Rua Branca Edm\u00e9e Marques, Lisboa, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"key\n\t\t\t\t20180607084731_CIT0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/19416520903053598","article-title":"How actors change institutions: towards a theory of institutional entrepreneurship","volume":"3","author":"Battilana","year":"2009","journal-title":"Academy of Management Annals"},{"key":"key\n\t\t\t\t20180607084731_CIT0002","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/00130095.2015.1103177","article-title":"Path creation as a process of resource alignment and anchoring: industry formation for on-site water recycling in Beijing","volume":"92","author":"Binz","year":"2016","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0080","unstructured":"Biocant. (2012) Annual Report 2011. Cantanhede: Biocant."},{"key":"key\n\t\t\t\t20180607084731_CIT0003","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/17487870.2016.1212711","article-title":"Addressing the disenchantment: universities and regional development in peripheral regions","volume":"20","author":"Bonaccorsi","year":"2017","journal-title":"Journal of Economic Policy Reform"},{"key":"key\n\t\t\t\t20180607084731_CIT0004","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/0034340042000292601","article-title":"Competitiveness of regions from an evolutionary perspective","volume":"38","author":"Boschma","year":"2004","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0005","volume-title":"Evolutionary Economic Geography and Its Implications for Regional Innovation Policy","author":"Boschma","year":"2009"},{"key":"key\n\t\t\t\t20180607084731_CIT0006","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00343404.2016.1254767","article-title":"Relatedness as driver of regional diversification: a research agenda","volume":"51","author":"Boschma","year":"2017","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0007","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.respol.2015.06.013","article-title":"Institutions and diversification: related versus unrelated diversification in a varieties of capitalism framework","volume":"44","author":"Boschma","year":"2015","journal-title":"Research Policy"},{"key":"key\n\t\t\t\t20180607084731_CIT0008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/00343404.2016.1258460","article-title":"Towards a theory of regional diversification: combining insights from evolutionary economic geography and transition studies","volume":"51","author":"Boschma","year":"2017","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0009","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/jeg\/lbq053","article-title":"The emerging empirics of evolutionary economic geography","volume":"11","author":"Boschma","year":"2011","journal-title":"Journal of Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0010","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/09654313.2012.651801","article-title":"Green urban transport policies and cleantech innovations: evidence from Curitiba, G\u00f6teborg and Hamburg","volume":"20","author":"Carvalho","year":"2012","journal-title":"European Planning Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0011","volume-title":"The Marketplace for Ideas: Can Los Angeles Build a Successful Biotechnology Cluster?","author":"Casper","year":"2009"},{"key":"key\n\t\t\t\t20180607084731_CIT0012","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.techsoc.2010.10.006","article-title":"Local niche experimentation in energy transitions: a theoretical and empirical exploration of proximity advantages and disadvantages","volume":"32","author":"Coenen","year":"2010","journal-title":"Technology in Society"},{"key":"key\n\t\t\t\t20180607084731_CIT0013","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1080\/09654313.2016.1246517","article-title":"Related variety and economic development: a literature review","volume":"24","author":"Content","year":"2016","journal-title":"European Planning Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0014","volume-title":"The Governance of Innovation in Europe","author":"Cooke","year":"2000"},{"key":"key\n\t\t\t\t20180607084731_CIT0015","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/jeg\/lbx001","article-title":"Quality of government and social capital as drivers of regional diversification in Europe","volume":"17","author":"Cortinovis","year":"2017","journal-title":"Journal of Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0016","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1068\/a45221","article-title":"Social capital and the innovative performance of Italian provinces","volume":"45","author":"Crescenzi","year":"2013","journal-title":"Environment and Planning A"},{"key":"key\n\t\t\t\t20180607084731_CIT0017","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/ecge.12028","article-title":"Creating new paths? Offshore wind, policy activism, and peripheral region development","volume":"90","author":"Dawley","year":"2014","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0018","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/cjres\/rsu036","article-title":"Policy activism and regional path creation: the promotion of offshore wind in North East England and Scotland","volume":"8","author":"Dawley","year":"2015","journal-title":"Cambridge Journal of Regions, Economy and Society"},{"key":"key\n\t\t\t\t20180607084731_CIT0019","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0169-7218(10)01008-7","article-title":"Stylized facts in the geography of innovation","volume-title":"Handbook of the Economics of Innovation","author":"Feldman","year":"2010"},{"key":"key\n\t\t\t\t20180607084731_CIT0020","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1077800405284363","article-title":"Five misunderstandings about case-study research","volume":"12","author":"Flyvbjerg","year":"2006","journal-title":"Qualitative Inquiry"},{"key":"key\n\t\t\t\t20180607084731_CIT0021","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/09654310500188498","article-title":"Distant networking: the knowledge acquisition strategies of \u2018out-cluster\u2019 biotechnology firms","volume":"13","author":"Fontes","year":"2005","journal-title":"European Planning Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0022","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1177\/0170840607078958","article-title":"Institutional entrepreneurship as embedded agency: an introduction to the special issue","volume":"28","author":"Garud","year":"2007","journal-title":"Organization Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0023","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0048-7333(02)00100-2","article-title":"Bricolage versus breakthrough: distributed and embedded agency in technology entrepreneurship","volume":"32","author":"Garud","year":"2003","journal-title":"Research Policy"},{"key":"key\n\t\t\t\t20180607084731_CIT0024","volume-title":"Case Studies and Theory Development in the Social Sciences","author":"George","year":"2005"},{"key":"key\n\t\t\t\t20180607084731_CIT0025","volume-title":"Transformation Capacity of the Innovative Entrepreneur: On the interplay between social structure and agency","author":"Grillitsch","year":"2017"},{"key":"key\n\t\t\t\t20180607084731_CIT0026","author":"INE\u2014National Statistics Office","year":"2017"},{"key":"key\n\t\t\t\t20180607084731_CIT0027","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/jeg\/lbu026","article-title":"Industrial development in thin regions: trapped in path extension","volume":"15","author":"Isaksen","year":"2014","journal-title":"Journal of Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0028","volume-title":"New Path Development in the Periphery","author":"Isaksen","year":"2014"},{"key":"key\n\t\t\t\t20180607084731_CIT0029","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/00130095.2016.1154443","article-title":"Exogenously led and policy-supported new path development in peripheral regions: analytical and synthetic routes","volume":"93","author":"Isaksen","year":"2017","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1944-8287.2009.01017.x","article-title":"Evolution in economic geography: institutions, political economy, and adaptation","volume":"85","author":"MacKinnon","year":"2009","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1944-8287.2009.01056.x","article-title":"Roepke lecture in economic geography\u2014rethinking regional path dependence: beyond lock-in to evolution","volume":"86","author":"Martin","year":"2010","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0032","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/jeg\/lbl012","article-title":"Path dependence and regional economic evolution","volume":"6","author":"Martin","year":"2006","journal-title":"Journal of Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0033","volume-title":"High Tech Fantasies. Science Parks in Society, Science and Space","author":"Massey","year":"1992"},{"key":"key\n\t\t\t\t20180607084731_CIT0034","volume-title":"Industry Evolution in Varieties of Capitalism: A Comparison of the Danish and US Wind Turbine Industries","author":"Menzel","year":"2017"},{"key":"key\n\t\t\t\t20180607084731_CIT0035","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2307\/2667089","article-title":"Organizational improvisation and learning: a field study","volume":"46","author":"Miner","year":"2001","journal-title":"Administrative Science Quarterly"},{"key":"key\n\t\t\t\t20180607084731_CIT0036","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/00130095.2017.1391691","article-title":"Agents of structural change: the role of firms and entrepreneurs in regional diversification","volume":"94","author":"Neffke","year":"2018","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0037","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1944-8287.2011.01121.x","article-title":"How do regions diversify over time? Industry relatedness and the development of new growth paths in regions","volume":"87","author":"Neffke","year":"2011","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0038","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/0969776409352156","article-title":"Development in peripheral regions: case studies in Sweden","volume":"17","author":"Nuur","year":"2010","journal-title":"European Urban and Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0039","volume-title":"A Framework for Biotechnology Statistics","author":"OECD","year":"2005"},{"key":"key\n\t\t\t\t20180607084731_CIT0040","doi-asserted-by":"crossref","DOI":"10.23943\/princeton\/9780691148670.001.0001","volume-title":"The Emergence of Organizations and Markets","author":"Padgett","year":"2012"},{"key":"key\n\t\t\t\t20180607084731_CIT0041","doi-asserted-by":"crossref","first-page":"622","DOI":"10.5465\/amr.2005.17293731","article-title":"What determines the scope of the firm over time? A focus on institutional relatedness","volume":"30","author":"Peng","year":"2005","journal-title":"Academy of Management Review"},{"key":"key\n\t\t\t\t20180607084731_CIT0042","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/cjres\/rsq001","article-title":"Resilience, adaptation and adaptability","volume":"3","author":"Pike","year":"2010","journal-title":"Cambridge Journal of Regions"},{"key":"key\n\t\t\t\t20180607084731_CIT0043","doi-asserted-by":"crossref","DOI":"10.4324\/9781315767673","volume-title":"Local and Regional Development","author":"Pike","year":"2016"},{"key":"key\n\t\t\t\t20180607084731_CIT0044","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1515\/9781400845552-018","article-title":"Organizational and institutional genesis: the emergence of high-tech clusters in the life sciences","volume-title":"The Emergence of Organizations and Markets","author":"Powell","year":"2012"},{"key":"key\n\t\t\t\t20180607084731_CIT0045","volume-title":"Making Democracy Work: Civic Traditions in Modern Italy","author":"Putnam","year":"1993"},{"key":"key\n\t\t\t\t20180607084731_CIT0046","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/00343404.2012.748978","article-title":"Do institutions matter for regional development","volume":"47","author":"Rodr\u00edguez-Pose","year":"2013","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0047","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/09654313.2012.716246","article-title":"Buzz, archipelago economies and the future of intermediate and peripheral areas in a spiky world","volume":"21","author":"Rodr\u00edguez-Pose","year":"2013","journal-title":"European Planning Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0048","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/00343400310001632226","article-title":"Between development and social policies: the impact of European Structural Funds in Objective 1 regions","volume":"38","author":"Rodr\u00edguez-Pose","year":"2004","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0081","unstructured":"Saxenian, A. (1994) Regional Advantage: Culture and Competition in Silicon Valley and Route 128. Cambridge, MA: Harvard University Press."},{"key":"key\n\t\t\t\t20180607084731_CIT0049","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1944-8287.2008.00001.x","article-title":"Roepke lecture in economic geography venture capital in the \u2018periphery\u2019: the new argonauts, global search, and local institution building","volume":"84","author":"Saxenian","year":"2008","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0050","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/09654313.2012.667924","article-title":"Path dependence and new technological path creation in the Danish wind power industry","volume":"20","author":"Simmie","year":"2012","journal-title":"European Planning Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0051","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.respol.2011.12.012","article-title":"What is protective space? Reconsidering niches in transitions to sustainability","volume":"41","author":"Smith","year":"2012","journal-title":"Research Policy"},{"key":"key\n\t\t\t\t20180607084731_CIT0052","first-page":"584","article-title":"An actor-centric bottom-up view of institutions: combinatorial knowledge dynamics through the eyes of institutional entrepreneurs and institutional navigators","volume":"35","author":"Sotarauta","year":"2016","journal-title":"Environment and Planning C: Government and Policy"},{"key":"key\n\t\t\t\t20180607084731_CIT0053","doi-asserted-by":"crossref","DOI":"10.11126\/stanford\/9780804789400.001.0001","volume-title":"The Rise and Fall of Urban Economies: Lessons From San Francisco and Los Angeles","author":"Storper","year":"2015"},{"key":"key\n\t\t\t\t20180607084731_CIT0054","volume-title":"The Capitalist Imperative: Territory, Technology, and Industrial Growth","author":"Storper","year":"1989"},{"key":"key\n\t\t\t\t20180607084731_CIT0055","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/ecge.12055","article-title":"Regional branching reconsidered: emergence of the fuel cell industry in European regions","volume":"90","author":"Tanner","year":"2014","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0056","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.respol.2005.01.018","article-title":"One size fits all? Towards a differentiated regional innovation policy approach","volume":"34","author":"T\u00f6dtling","year":"2005","journal-title":"Research Policy"},{"key":"key\n\t\t\t\t20180607084731_CIT0057","article-title":"Exogenous sources of regional industrial change: attraction and absorption of non-local knowledge for new path development","author":"Trippl","year":"2017","journal-title":"Progress in Human Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0058","first-page":"413","article-title":"Innovation networks and local and regional development policy","volume-title":"Handbook of Local and Regional Development","author":"Vale","year":"2011"},{"key":"key\n\t\t\t\t20180607084731_CIT0059","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1080\/00343404.2011.644237","article-title":"Knowledge networks and processes of anchoring in Portuguese biotechnology","volume":"47","author":"Vale","year":"2013","journal-title":"Regional Studies"},{"key":"key\n\t\t\t\t20180607084731_CIT0060","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/00130095.2016.1146076","article-title":"Universities, public research, and evolutionary economic geography","volume":"92","author":"Vallance","year":"2016","journal-title":"Economic Geography"},{"key":"key\n\t\t\t\t20180607084731_CIT0061","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.rser.2012.11.011","article-title":"The development of solar PV in the Netherlands: a case of survival in unfriendly contexts","volume":"19","author":"Verhees","year":"2013","journal-title":"Renewable and Sustainable Energy Reviews"},{"key":"key\n\t\t\t\t20180607084731_CIT0062","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4018\/978-1-59904-720-1.ch012","article-title":"Urban competitiveness in the knowledge economy: evolution paths of the Portuguese metropolises","volume-title":"Knowledge Based Urban Development","author":"van Winden","year":"2008"},{"key":"key\n\t\t\t\t20180607084731_CIT0063","doi-asserted-by":"crossref","DOI":"10.1080\/00130095.2018.1444989","article-title":"Industrial diversification in Europe: the differentiated role of relatedness","author":"Xiao","year":"2018"}],"container-title":["Cambridge Journal of Regions, Economy and Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cjres\/article-pdf\/11\/2\/275\/25019014\/rsy009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:18:45Z","timestamp":1603970325000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cjres\/article\/11\/2\/275\/4975539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,4,18]]},"published-print":{"date-parts":[[2018,6,7]]}},"URL":"https:\/\/doi.org\/10.1093\/cjres\/rsy009","relation":{},"ISSN":["1752-1378","1752-1386"],"issn-type":[{"value":"1752-1378","type":"print"},{"value":"1752-1386","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,4,18]]}}}