{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:38:11Z","timestamp":1768887491850,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FCT\/MCTES","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}]},{"name":"North Portugal Regional Coordination and Development Commission","award":["Norte-01-0145-FEDER-000024"],"award-info":[{"award-number":["Norte-01-0145-FEDER-000024"]}]},{"name":"FCT\/MCTES","award":["PTDC\/MEC-CAR\/31322\/2017"],"award-info":[{"award-number":["PTDC\/MEC-CAR\/31322\/2017"]}]},{"name":"FEDER\/COMPETE 2020","award":["POCI-01-0145-FEDER-031322"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031322"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>DNA damage and inflammation are common in end-stage renal disease (ESRD). Our aim was to evaluate the levels of circulating cell-free DNA (cfDNA) and the relationship with inflammation, anaemia, oxidative stress and haemostatic disturbances in ESRD patients on dialysis. By performing a 1-year follow-up study, we also aimed to evaluate the predictive value of cfDNA for the outcome of ESRD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 289 ESRD patients on dialysis were enrolled in the study: we evaluated cfDNA, haemogram, serum iron, hepcidin, inflammatory and oxidative stress markers, and haemostasis. Events and causes of deaths were recorded throughout the follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ESRD patients, as compared with controls, presented significantly higher levels of cfDNA, hepcidin, and inflammatory and oxidative stress markers, and significantly lower values of iron and anaemia-related haemogram parameters. The all-cause mortality rate was 9.7%; compared with alive patients, deceased patients (n\u2009=\u200928) were older and presented significantly higher values of inflammatory markers and of cfDNA, which was almost 2-fold higher. Furthermore, cfDNA was the best predictor of all-cause mortality and cardiovascular mortality in ESRD patients, in both unadjusted and adjusted models for basic confounding factors in dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show cfDNA to be a valuable predictive marker of prognosis in ESRD patients on dialysis treatment; high levels of cfDNA were associated with a poor outcome.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ckj\/sfaa115","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T03:31:10Z","timestamp":1589427070000},"page":"1371-1378","source":"Crossref","is-referenced-by-count":16,"title":["Cell-free DNA as a marker for the outcome of end-stage renal disease patients on haemodialysis"],"prefix":"10.1093","volume":"14","author":[{"given":"Susana","family":"Coimbra","sequence":"first","affiliation":[{"name":"UCIBIO\/REQUIMTE, Porto, Portugal"},{"name":"CESPU, Institute of Research and Advanced 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