{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:36:30Z","timestamp":1756312590737,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["102538"],"award-info":[{"award-number":["102538"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with kidney failure have a higher cancer risk compared with the age-matched general population. However, the outcomes of incident dialysis patients with a prior cancer history are unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using Australia and New Zealand Dialysis and Transplant Registry data (2000\u20132019), the outcomes and survival probabilities of incident dialysis patients with prior cancers and having experienced a cancer recurrence or having developed a new cancer after dialysis commencement were described.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 4912 patients with prior cancers before dialysis commencement, 323 (7%) and 343 (7%) patients experienced cancer recurrence or developed new cancers after dialysis initiation, respectively. The median time from dialysis commencement to cancer recurrence was 1.2 years [interquartile range (IQR) 0.5\u20132.8] and was 2.0 years (IQR 0.7\u20134.0) for new cancer occurrence. Of those with cancer recurrence, 80% presented with metastatic disease and one in two patients died from cancer, with a median time from cancer recurrence to death of 0.5 years (IQR 0.2\u20131.7). Of those who developed new cancer, urinary tract and respiratory cancers were the most frequent cancer types, with a median time from new cancer diagnosis to death of 1.3 years (IQR 0.4\u20133.1). The 3-year survival probabilities on dialysis following cancer recurrence and new cancer were 19% [95% confidence interval (CI) 15\u201324] and 41% (35\u201347), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among incident dialysis patients with a prior cancer history, 14% experienced cancer recurrence or developed a new cancer. Patients who experienced cancer recurrence or developed new cancer have poor outcomes, with \u02c250% surviving beyond 3 years. These findings suggest the need to have a greater understanding of the characteristics, cancer screening, treatment responses and reasons for commencing dialysis in patients with kidney failure and prior cancer history, which may help in the shared clinical decision-making process when considering dialysis for these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfac124","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T14:24:16Z","timestamp":1654179856000},"page":"1770-1781","source":"Crossref","is-referenced-by-count":5,"title":["The incidence of cancer recurrence and new cancer following commencement of dialysis"],"prefix":"10.1093","volume":"15","author":[{"given":"Wai H","family":"Lim","sequence":"first","affiliation":[{"name":"Medical School, University of Western Australia , Perth , Western Australia, Australia"},{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital , Perth , Western Australia, Australia"}]},{"given":"Esther","family":"Ooi","sequence":"additional","affiliation":[{"name":"Medical School, University of Western Australia , Perth , Western Australia, Australia"},{"name":"School of Biomedical Sciences, University of Western Australia , Perth , Western Australia, Australia"}]},{"given":"Aashi","family":"Pankaj","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia , Perth , Western Australia, Australia"}]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health, Sydney University , Sydney, New South Wales, Australia"}]},{"given":"Yingxin","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health, Sydney University , Sydney, New South Wales, Australia"},{"name":"Faculty of Science, School of Mathematics and Science, University of Sydney , Sydney, New South Wales, Australia"}]},{"given":"David W","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital , Woolloongabba, Queensland , Australia"},{"name":"Australasian Kidney Trials Network, University of Queensland , Queensland , Australia"},{"name":"Translational Research Institute , Brisbane, Queensland , Australia"}]},{"given":"Carmel M","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital , Woolloongabba, Queensland , Australia"},{"name":"Australasian Kidney Trials Network, University of Queensland , Queensland , Australia"},{"name":"Translational Research Institute , Brisbane, Queensland , Australia"}]},{"given":"Andrea K","family":"Viecelli","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Princess Alexandra Hospital , Woolloongabba, Queensland , Australia"},{"name":"Australasian Kidney Trials Network, University of Queensland , Queensland , Australia"}]},{"given":"Helen","family":"Pilmore","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Auckland City Hospital , Auckland , New Zealand"},{"name":"Department of Medicine, Auckland University , Auckland , New Zealand"}]},{"given":"Matthew A","family":"Roberts","sequence":"additional","affiliation":[{"name":"Eastern Health Clinical School, Monash University , Melbourne, Victoria , Australia"}]},{"given":"Christopher E","family":"Davies","sequence":"additional","affiliation":[{"name":"Australia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute , Adelaide, South Australia, Australia"},{"name":"Adelaide Medical School, University of Adelaide , Adelaide, South Australia, Australia"}]},{"given":"Anoushka","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Royal Perth Hospital , Perth , Westen Australia, Australia"}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health, Sydney University , Sydney, New South Wales, Australia"},{"name":"Centre for Kidney Research, Children's Hospital at Westmead , Sydney, New South Wales, Australia"},{"name":"Department of Renal Medicine and National Pancreas Transplant Unit, Westmead Hospital , Sydney, New South Wales, Australia"}]}],"member":"286","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"2022082216173842300_bib1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1681\/ASN.2015040373","article-title":"Variation in cancer incidence among patients with ESRD during kidney function and nonfunction intervals","volume":"27","author":"Yanik","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2022082216173842300_bib2","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1001\/jama.2011.1592","article-title":"Spectrum of cancer 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