{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:40:33Z","timestamp":1777002033397,"version":"3.51.4"},"reference-count":244,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Heart failure\u2014either with reduced or preserved ejection fraction (HFrEF\/HFpEF)\u2014is a clinical syndrome of multifactorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body\u2019s needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.<\/jats:p>","DOI":"10.1093\/cvr\/cvab009","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T14:46:47Z","timestamp":1610117207000},"page":"2416-2433","source":"Crossref","is-referenced-by-count":49,"title":["Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-1960","authenticated-orcid":false,"given":"Michele","family":"Ciccarelli","sequence":"first","affiliation":[{"name":"University of Salerno, Department of Medicine, Surgery and Dentistry, Via S. Allende 1, 84081, Baronissi (Salerno),","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-4469","authenticated-orcid":false,"given":"Dana","family":"Dawson","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, University of Aberdeen , Aberdeen AB25 2DZ,","place":["UK"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-3782","authenticated-orcid":false,"given":"In\u00eas","family":"Falcao-Pires","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 , Porto,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-7225","authenticated-orcid":false,"given":"Mauro","family":"Giacca","sequence":"additional","affiliation":[{"name":"King\u2019s College London , Molecular Medicine Laboratory, 125 Caldharbour Lane, London WC2R2LS,","place":["United 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Cardiovascular Diseases , Universiteitssingel 50, 6229 ER Maastricht, the","place":["Netherlands"]},{"name":"ICIN-Netherlands Heart Institute, Holland Heart House , Moreelsepark 1, 3511 EP Utrecht, the","place":["Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-6640","authenticated-orcid":false,"given":"Astrid","family":"Hooghiemstra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam , Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1118, 1081HZ, Amsterdam, The","place":["Netherlands"]},{"name":"Department of Medical Humanities, Amsterdam Public Health Research Institute , Amsterdam UMC, Location VUmc, De Boelelaan 1089a, 1081HV, Amsterdam, The","place":["Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-1738","authenticated-orcid":false,"given":"Annebet","family":"Leeuwis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam , Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1118, 1081HZ, Amsterdam, The","place":["Netherlands"]}]},{"given":"Dorien","family":"Hermkens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Meibergdreef 9, 1105AZ, Amsterdam,","place":["the Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-688X","authenticated-orcid":false,"given":"Carlo Gabriele","family":"Tocchetti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences and Interdepartmental Center of Clinical and Translational Research (CIRCET), Federico II University , Naples,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-5788","authenticated-orcid":false,"given":"Jolanda","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam 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