{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:07:10Z","timestamp":1768478830234,"version":"3.49.0"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leducq Foundation and the European Research Council","award":["ZMOD 694455"],"award-info":[{"award-number":["ZMOD 694455"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a well-established genetic model to study cardiovascular development and function; however, analysis of cardiovascular phenotypes in adult specimens is particularly challenging as they are opaque.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Here, we optimized and combined multiple imaging techniques including echocardiography, magnetic resonance imaging, and micro-computed tomography to identify and analyse cardiovascular phenotypes in adult zebrafish. Using alk5a\/tgfbr1a mutants as a case study, we observed morphological and functional cardiovascular defects that were undetected with conventional approaches. Correlation analysis of multiple parameters revealed an association between haemodynamic defects and structural alterations of the heart, as observed clinically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report a new, comprehensive, and sensitive platform to identify otherwise indiscernible cardiovascular phenotypes in adult zebrafish.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cvr\/cvab310","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T15:58:18Z","timestamp":1633017498000},"page":"2665-2687","source":"Crossref","is-referenced-by-count":8,"title":["Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-2232","authenticated-orcid":false,"given":"Anabela","family":"Bensimon-Brito","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"},{"name":"DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main , Bad Nauheim , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-7985","authenticated-orcid":false,"given":"Giulia L M","family":"Boezio","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"},{"name":"DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main , Bad Nauheim , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-8810","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Cardeira-da-Silva","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"},{"name":"DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main , Bad Nauheim , Germany"}]},{"given":"Astrid","family":"Wietelmann","sequence":"additional","affiliation":[{"name":"Scientific Service Group MRI and \u00b5-CT, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-0428","authenticated-orcid":false,"given":"Srinath","family":"Ramkumar","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"},{"name":"DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main , Bad Nauheim , Germany"},{"name":"Department of Life Sciences, Goethe University Frankfurt am Main , Frankfurt , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-1844","authenticated-orcid":false,"given":"Pia R","family":"Lundegaard","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Cardiology, Department of Cardiology, Vascular, Pulmonary and Infectious Diseases, University Hospital of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Biomedical Sciences, University of Copenhagen , Copenhagen , Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-5338","authenticated-orcid":false,"given":"Christian S M","family":"Helker","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"}]},{"given":"Radhan","family":"Ramadass","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"}]},{"given":"Janett","family":"Piesker","sequence":"additional","affiliation":[{"name":"Scientific Service Group Microscopy, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"}]},{"given":"Arno","family":"Nauerth","sequence":"additional","affiliation":[{"name":"Bruker Biospin MRI GmbH , Ettlingen , Germany"}]},{"given":"Clemens","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kerckhoff-Klinik , Bad Nauheim , Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-0026","authenticated-orcid":false,"given":"Didier Y R","family":"Stainier","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research , Bad Nauheim , Germany"},{"name":"DZHK German Centre for Cardiovascular Research, Partner Site Rhine-Main , Bad Nauheim , Germany"}]}],"member":"286","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"2022092120261114300_cvab310-B1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/eurheartj\/ehs397","article-title":"Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases","volume":"34","author":"Rapezzi","year":"2013","journal-title":"Eur Heart J"},{"key":"2022092120261114300_cvab310-B2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tcm.2003.12.006","article-title":"Studying cardiac arrhythmias in the mouse\u2013a reasonable model for probing mechanisms?","volume":"14","author":"Nerbonne","year":"2004","journal-title":"Trends Cardiovasc Med"},{"key":"2022092120261114300_cvab310-B3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pharmthera.2013.10.007","article-title":"Small and large animal models in cardiac contraction research: advantages and disadvantages","volume":"141","author":"Milani-Nejad","year":"2014","journal-title":"Pharmacol Ther"},{"key":"2022092120261114300_cvab310-B4","doi-asserted-by":"crossref","first-page":"497841","DOI":"10.1155\/2011\/497841","article-title":"Animal models of cardiovascular diseases","volume":"2011","author":"Zaragoza","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"2022092120261114300_cvab310-B5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/35047564","article-title":"Zebrafish genetics and vertebrate heart formation","volume":"2","author":"Stainier","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2022092120261114300_cvab310-B6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/cvr\/cvr098","article-title":"Zebrafish as a model to study cardiac development and human cardiac disease","volume":"91","author":"Bakkers","year":"2011","journal-title":"Cardiovasc Res"},{"key":"2022092120261114300_cvab310-B7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-genet-110711-155646","article-title":"Uncovering the molecular and cellular mechanisms of heart development using the zebrafish","volume":"46","author":"StaudtStainier","year":"2012","journal-title":"Annu Rev Genet"},{"key":"2022092120261114300_cvab310-B8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1242\/dev.123.1.285","article-title":"Mutations affecting the formation and function of the cardiovascular system in the zebra\ufb01sh embryo","volume":"123","author":"Stainier","year":"1996","journal-title":"Development"},{"key":"2022092120261114300_cvab310-B9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tcb.2005.12.001","article-title":"In vivo cell biology: following the zebrafish trend","volume":"16","author":"Beis","year":"2006","journal-title":"Trends Cell Biol"},{"key":"2022092120261114300_cvab310-B10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nmeth.3037","article-title":"High-resolution reconstruction of the beating zebrafish heart","volume":"11","author":"Mickoleit","year":"2014","journal-title":"Nat Methods"},{"key":"2022092120261114300_cvab310-B11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCRESAHA.119.315992","article-title":"Nfatc1 promotes interstitial cell formation during cardiac valve development in zebrafish","volume":"126","author":"Gunawan","year":"2020","journal-title":"Circ Res"},{"key":"2022092120261114300_cvab310-B12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yjmcc.2009.08.034","article-title":"Adult zebrafish heart as a model for human heart? An electrophysiological study","volume":"48","author":"Nemtsas","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"2022092120261114300_cvab310-B13","doi-asserted-by":"crossref","first-page":"H1152","DOI":"10.1152\/ajpheart.00870.2002","article-title":"Functional and morphological evidence for a ventricular conduction system in zebrafish and Xenopus hearts","volume":"284","author":"Sedmera","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022092120261114300_cvab310-B14","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1242\/jeb.01620","article-title":"Cardiac performance in the zebrafish breakdance mutant","volume":"208","author":"Kopp","year":"2005","journal-title":"J Exp Biol"},{"key":"2022092120261114300_cvab310-B15","doi-asserted-by":"crossref","first-page":"H269","DOI":"10.1152\/ajpheart.00960.2005","article-title":"In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation","volume":"291","author":"Milan","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2022092120261114300_cvab310-B16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pbiomolbio.2018.06.008","article-title":"Ionic basis of cardiac electrophysiology in zebrafish compared to human hearts","volume":"138","author":"Ravens","year":"2018","journal-title":"Prog Biophys Mol Biol"},{"key":"2022092120261114300_cvab310-B17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pbiomolbio.2009.01.011","article-title":"Zebrafish genetic models for arrhythmia","volume":"98","author":"Milan","year":"2008","journal-title":"Prog Biophys Mol Biol"},{"key":"2022092120261114300_cvab310-B18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/19336950.2015.1121335","article-title":"Zebrafish heart as a model for human cardiac electrophysiology","volume":"10","author":"VornanenHassinen","year":"2016","journal-title":"Channels (Austin)"},{"key":"2022092120261114300_cvab310-B19","doi-asserted-by":"crossref","first-page":"e0232457","DOI":"10.1371\/journal.pone.0232457","article-title":"Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish","volume":"15","author":"Yan","year":"2020","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/scitranslmed.3008008","article-title":"Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy","volume":"6","author":"Asimaki","year":"2014","journal-title":"Sci Transl Med"},{"key":"2022092120261114300_cvab310-B21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/CIRCGENETICS.114.000702","article-title":"Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish","volume":"8","author":"Shih","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"2022092120261114300_cvab310-B22","doi-asserted-by":"crossref","first-page":"24115","DOI":"10.1073\/pnas.1913905116","article-title":"Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model","volume":"116","author":"Collins","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022092120261114300_cvab310-B23","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1242\/dev.139246","article-title":"Exon- and contraction-dependent functions of titin in sarcomere assembly","volume":"143","author":"Shih","year":"2016","journal-title":"Development"},{"key":"2022092120261114300_cvab310-B24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCRESAHA.112.300603","article-title":"Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening","volume":"112","author":"Ding","year":"2013","journal-title":"Circ Res"},{"key":"2022092120261114300_cvab310-B25","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1038\/s41467-018-06618-y","article-title":"Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation","volume":"9","author":"Ahlberg","year":"2018","journal-title":"Nat Commun"},{"key":"2022092120261114300_cvab310-B26","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"2022092120261114300_cvab310-B27","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nprot.2012.025","article-title":"Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish","volume":"7","author":"Gonzalez-Rosa","year":"2012","journal-title":"Nat Protoc"},{"key":"2022092120261114300_cvab310-B28","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ydbio.2020.12.004","article-title":"Is zebrafish heart regeneration \u201ccomplete\u201d? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts","volume":"471","author":"Bertozzi","year":"2021","journal-title":"Dev Biol"},{"key":"2022092120261114300_cvab310-B29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/physrev.00038.2016","article-title":"Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease","volume":"97","author":"Gut","year":"2017","journal-title":"Physiol Rev"},{"key":"2022092120261114300_cvab310-B30","doi-asserted-by":"crossref","first-page":"e44898","DOI":"10.7554\/eLife.44898","article-title":"Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography","volume":"8","author":"Ding","year":"2019","journal-title":"Elife"},{"key":"2022092120261114300_cvab310-B31","doi-asserted-by":"crossref","first-page":"e0122665","DOI":"10.1371\/journal.pone.0122665","article-title":"Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury","volume":"10","author":"Hein","year":"2015","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mri.2016.10.013","article-title":"Rapid and recoverable in vivo magnetic resonance imaging of the adult zebrafish at 7T","volume":"37","author":"Merrifield","year":"2017","journal-title":"Magn Reson Imaging"},{"key":"2022092120261114300_cvab310-B33","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/s41598-017-03050-y","article-title":"High-resolution magnetic resonance imaging of the regenerating adult zebrafish heart","volume":"7","author":"Koth","year":"2017","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B34","doi-asserted-by":"crossref","first-page":"e26014","DOI":"10.7554\/eLife.26014","article-title":"MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system","volume":"6","author":"Hur","year":"2017","journal-title":"Elife"},{"key":"2022092120261114300_cvab310-B35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pbiomolbio.2018.05.013","article-title":"Phenotyping cardiomyopathy in adult zebrafish","volume":"138","author":"Dvornikov","year":"2018","journal-title":"Prog Biophys Mol Biol"},{"key":"2022092120261114300_cvab310-B36","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.cell.2012.03.001","article-title":"Genetics of human cardiovascular disease","volume":"148","author":"Kathiresan","year":"2012","journal-title":"Cell"},{"key":"2022092120261114300_cvab310-B37","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00439-013-1331-2","article-title":"Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease","volume":"132","author":"Cooper","year":"2013","journal-title":"Hum Genet"},{"key":"2022092120261114300_cvab310-B38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12968-017-0327-9","article-title":"Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort","volume":"19","author":"Petersen","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022092120261114300_cvab310-B39","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jcmg.2018.06.003","article-title":"Multi-modality imaging in the assessment of cardiovascular toxicity in the cancer patient","volume":"11","author":"Plana","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/ehjci\/jev337","article-title":"Normal values of left ventricular mass and cardiac chamber volumes assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study","volume":"17","author":"Fuchs","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B41","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCIMAGING.113.000498","article-title":"Use of cardiac magnetic resonance and echocardiography in population-based studies","volume":"6","author":"Marwick","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B42","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.1038\/s41598-017-09152-x","article-title":"Automated segmentation of light-sheet fluorescent imaging to characterize experimental doxorubicin-induced cardiac injury and repair","volume":"7","author":"Packard","year":"2017","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B43","doi-asserted-by":"crossref","first-page":"A96.2","DOI":"10.1136\/heartjnl-2015-308066.170","article-title":"170 In vivo cardiac magnetic resonance imaging of adult zebrafish","volume":"101","author":"Merrifield","year":"2015","journal-title":"Heart"},{"key":"2022092120261114300_cvab310-B44","first-page":"1387","article-title":"Development of cardiac MRI for studying zebrafish models of cardiovascular disease","volume":"21","author":"Merrifield","year":"2013","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"2022092120261114300_cvab310-B45","doi-asserted-by":"crossref","first-page":"16531","DOI":"10.1038\/s41598-018-34848-z","article-title":"Quantitative morphometric analysis of adult teleost fish by X-ray computed tomography","volume":"8","author":"Weinhardt","year":"2018","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B46","first-page":"20","article-title":"Soft tissue discrimination with contrast agents using micro-CT scanning","volume":"144","author":"Descamps","year":"2014","journal-title":"Belg J Zool"},{"key":"2022092120261114300_cvab310-B47","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0301-5629(02)00564-1","article-title":"Assessment of zebrafish cardiac performance using Doppler echocardiography and power angiography","volume":"28","author":"Ho","year":"2002","journal-title":"Ultrasound Med Biol"},{"key":"2022092120261114300_cvab310-B48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ultrasmedbio.2007.07.002","article-title":"In vivo cardiac imaging of adult zebrafish using high frequencyultrasound (45\u201375 MHz)","volume":"34","author":"Sun","year":"2008","journal-title":"Ultrasound Med Biol"},{"key":"2022092120261114300_cvab310-B49","doi-asserted-by":"crossref","first-page":"e53748","DOI":"10.1371\/journal.pone.0053748","article-title":"Hypoxia\/reoxygenation cardiac injury and regeneration in zebrafish adult heart","volume":"8","author":"Parente","year":"2013","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B50","doi-asserted-by":"crossref","first-page":"e115604","DOI":"10.1371\/journal.pone.0115604","article-title":"Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish","volume":"9","author":"Gonz\u00e1lez-Rosa","year":"2014","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B51","doi-asserted-by":"crossref","first-page":"e0145163","DOI":"10.1371\/journal.pone.0145163","article-title":"Functional assessment of cardiac responses of adult zebrafish (Danio rerio) to acute and chronic temperature change using high-resolution echocardiography","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2015.07.025","article-title":"Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart","volume":"414","author":"Wilson","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"2022092120261114300_cvab310-B53","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/zeb.2016.1274","article-title":"Use of coronary ultrasound imaging to evaluate ventricular function in adult zebrafish","volume":"13","author":"Ernens","year":"2016","journal-title":"Zebrafish"},{"key":"2022092120261114300_cvab310-B54","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fbioe.2019.00096","article-title":"Adaptation of a mice Doppler echocardiography platform to measure cardiac flow velocities for embryonic chicken and adult zebrafish","volume":"7","author":"Benslimane","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"2022092120261114300_cvab310-B55","first-page":"63","article-title":"Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models","volume":"10","author":"Wang","year":"2017","journal-title":"Dis Model Mech"},{"key":"2022092120261114300_cvab310-B56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/zeb.2014.1026","article-title":"High-resolution tissue Doppler imaging of the zebrafish heart during its regeneration","volume":"12","author":"Huang","year":"2015","journal-title":"Zebrafish"},{"key":"2022092120261114300_cvab310-B57","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117732","article-title":"Evaluation of cardiac dysfunction in adult zebrafish using high frequency echocardiography","volume":"253","author":"Fang","year":"2020","journal-title":"Life Sci"},{"key":"2022092120261114300_cvab310-B58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"2022092120261114300_cvab310-B59","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J Med"},{"key":"2022092120261114300_cvab310-B60","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/humu.20353","article-title":"Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in Marfan syndrome-related disorders","volume":"27","author":"Matyas","year":"2006","journal-title":"Hum Mutat"},{"key":"2022092120261114300_cvab310-B61","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3390\/genes10100764","article-title":"Genotypic categorization of Loeys-Dietz syndrome based on 24 novel families and literature data","volume":"10","author":"Camerota","year":"2019","journal-title":"Genes (Basel)"},{"key":"2022092120261114300_cvab310-B62","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/gim.2018.27","article-title":"Targeted genetic analysis in a large cohort of familial and sporadic cases of aneurysm or dissection of the thoracic aorta","volume":"20","author":"Weerakkody","year":"2018","journal-title":"Genet Med"},{"key":"2022092120261114300_cvab310-B63","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1242\/dev.02087","article-title":"Cellular and molecular analyses of vascular tube and lumen formation in zebrafish","volume":"132","author":"Jin","year":"2005","journal-title":"Development"},{"key":"2022092120261114300_cvab310-B64","doi-asserted-by":"crossref","first-page":"e57603","DOI":"10.7554\/eLife.57603","article-title":"Endothelial TGF-beta signaling instructs smooth muscle cell development in the cardiac outflow tract","volume":"9","author":"Boezio","year":"2020","journal-title":"Elife"},{"key":"2022092120261114300_cvab310-B65","first-page":"2752","article-title":"Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration","volume":"142","author":"Mateus","year":"2015","journal-title":"Development"},{"key":"2022092120261114300_cvab310-B66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.matbio.2006.09.011","article-title":"Differential expression of two tropoelastin genes in zebrafish","volume":"26","author":"Miao","year":"2007","journal-title":"Matrix Biol"},{"key":"2022092120261114300_cvab310-B67","first-page":"1","volume-title":"Methods Cell Biol","author":"Laue","year":"2010"},{"key":"2022092120261114300_cvab310-B68","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/10520296009114754","article-title":"Embedding in epoxy resins for ultrathin sectioning in electron microscopy","volume":"35","author":"Richardson","year":"1960","journal-title":"Stain Technol"},{"key":"2022092120261114300_cvab310-B69","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.1038\/s41598-018-33577-7","article-title":"Development of a rapid and economic in vivo electrocardiogram platform for cardiovascular drug assay and electrophysiology research in adult zebrafish","volume":"8","author":"Lin","year":"2018","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B70","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrcardio.2014.203","article-title":"Management of acute aortic syndrome","volume":"12","author":"Clough","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"2022092120261114300_cvab310-B71","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/cs0750285","article-title":"Metabolic and cardiovascular effects of infusions of low doses of isoprenaline in man","volume":"75","author":"Mansell","year":"1988","journal-title":"Clin Sci (Lond)"},{"key":"2022092120261114300_cvab310-B72","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1161\/CIRCULATIONAHA.107.755801","article-title":"Tight heart rate control reduces secondary adverse events in patients with Type B acute aortic dissection","volume":"118","author":"Kodama","year":"2008","journal-title":"Circulation"},{"key":"2022092120261114300_cvab310-B73","first-page":"17","article-title":"Self-gated, wireless cine-MRI allows accurate and time-efficient analysis of mouse heart function when conventional ECG-and respiratory gated cine MRI fails","volume":"14","author":"Van Echteld","year":"2006","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"2022092120261114300_cvab310-B74","first-page":"1648","article-title":"Slice refocusing signal for retrospective reconstruction of CINE cardiac MR images","volume":"14","author":"Nauerth","year":"2006","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"2022092120261114300_cvab310-B75","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diff.2012.05.005","article-title":"Zebrafish models in cardiac development and congenital heart birth defects","volume":"84","author":"Tu","year":"2012","journal-title":"Differentiation"},{"key":"2022092120261114300_cvab310-B76","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/B978-0-12-386930-2.00004-5","article-title":"Zebrafish as a model of cardiac disease","volume":"124","author":"Wilkinson","year":"2014","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2022092120261114300_cvab310-B77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/B978-0-12-387036-0.00007-4","article-title":"A guide to analysis of cardiac phenotypes in the zebrafish embryo","volume":"101","author":"Miura","year":"2011","journal-title":"Methods Cell Biol"},{"key":"2022092120261114300_cvab310-B78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ctdb.2016.11.010","article-title":"Modeling syndromic congenital heart defects in zebrafish","volume":"124","author":"Grant","year":"2017","journal-title":"Curr Top Dev Biol"},{"key":"2022092120261114300_cvab310-B79","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng875","article-title":"Cardiac troponin T is essential in sarcomere assembly and cardiac contractility","volume":"31","author":"Sehnert","year":"2002","journal-title":"Nat Genet"},{"key":"2022092120261114300_cvab310-B80","doi-asserted-by":"crossref","first-page":"e002135","DOI":"10.1161\/CIRCGEN.118.002135","article-title":"A-band titin truncation in zebrafish causes dilated cardiomyopathy and hemodynamic stress intolerance","volume":"11","author":"Huttner","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"2022092120261114300_cvab310-B81","doi-asserted-by":"crossref","first-page":"e32833","DOI":"10.7554\/eLife.32833","article-title":"Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish","volume":"7","author":"Guerra","year":"2018","journal-title":"eLife"},{"key":"2022092120261114300_cvab310-B82","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5935\/0103-507X.20180055","article-title":"Non-invasive hemodynamic evaluation by Doppler echocardiography","volume":"30","author":"Gaspar","year":"2018","journal-title":"Rev Bras Ter Intensiva"},{"key":"2022092120261114300_cvab310-B83","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1113\/expphysiol.2012.068577","article-title":"High-resolution echocardiography in the assessment of cardiac physiology and disease in preclinical models","volume":"98","author":"Moran","year":"2013","journal-title":"Exp Physiol"},{"key":"2022092120261114300_cvab310-B84","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.echo.2008.07.001","article-title":"Echocardiography in translational research: of mice and men","volume":"21","author":"Scherrer-Crosbie","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"2022092120261114300_cvab310-B85","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1253\/circj.CJ-18-0027","article-title":"High-frequency echocardiography- transformative clinical and research applications in humans, mice, and zebrafish","volume":"82","author":"Wang","year":"2018","journal-title":"Circ J"},{"key":"2022092120261114300_cvab310-B86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2019.10.027","article-title":"TGF\u00df signaling promotes tissue formation during cardiac valve regeneration in adult zebrafish","volume":"52","author":"Bensimon-Brito","year":"2020","journal-title":"Dev Cell"},{"key":"2022092120261114300_cvab310-B87","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrcardio.2014.159","article-title":"Cardiac MRI: a central prognostic tool in myocardial fibrosis","volume":"12","author":"Ambale-Venkatesh","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"2022092120261114300_cvab310-B88","doi-asserted-by":"crossref","first-page":"20150655","DOI":"10.1259\/bjr.20150655","article-title":"Accelerated MRI for the assessment of cardiac function","volume":"89","author":"AxelOtazo","year":"2016","journal-title":"Br J Radiol"},{"key":"2022092120261114300_cvab310-B89","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1136\/heartjnl-2015-309077","article-title":"Cardiac MRI evaluation of myocardial disease","volume":"102","author":"Captur","year":"2016","journal-title":"Heart"},{"key":"2022092120261114300_cvab310-B90","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/heartjnl-2014-306963","article-title":"MRI in the assessment of ischaemic heart disease","volume":"102","author":"Dastidar","year":"2016","journal-title":"Heart"},{"key":"2022092120261114300_cvab310-B91","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1148\/radiol.2019191476","article-title":"Diagnosis of myocarditis at cardiac MRI: the continuing quest for improved tissue characterization","volume":"292","author":"de Roos","year":"2019","journal-title":"Radiology"},{"key":"2022092120261114300_cvab310-B92","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12968-015-0111-7","article-title":"Normal values for cardiovascular magnetic resonance in adults and children","volume":"17","author":"Kawel-Boehm","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"key":"2022092120261114300_cvab310-B93","doi-asserted-by":"crossref","first-page":"e0187596","DOI":"10.1371\/journal.pone.0187596","article-title":"Preclinical 4D-flow magnetic resonance phase contrast imaging of the murine aortic arch","volume":"12","author":"Braig","year":"2017","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B94","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1361-8415(03)00011-2","article-title":"Cardiac magnetic resonance imaging in small animal models of human heart failure","volume":"7","author":"Nahrendorf","year":"2003","journal-title":"Med Image Anal"},{"key":"2022092120261114300_cvab310-B95","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/1874192401004010278","article-title":"Cardiovascular magnetic resonance imaging in experimental models","volume":"4","author":"Price","year":"2010","journal-title":"Open Cardiovasc Med J"},{"key":"2022092120261114300_cvab310-B96","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/zeb.2009.0649","article-title":"In vivo magnetic resonance imaging to detect malignant melanoma in adult zebrafish","volume":"7","author":"Kabli","year":"2010","journal-title":"Zebrafish"},{"key":"2022092120261114300_cvab310-B97","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/nbm.1593","article-title":"Evaluation of infarcted murine heart function: comparison of prospectively triggered with self-gated MRI","volume":"24","author":"Bovens","year":"2011","journal-title":"NMR Biomed"},{"key":"2022092120261114300_cvab310-B98","doi-asserted-by":"crossref","first-page":"39074","DOI":"10.1038\/srep39074","article-title":"High-resolution short-exposure small-animal laboratory X-ray phase-contrast tomography","volume":"6","author":"Larsson","year":"2016","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B99","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.rcl.2018.08.011","article-title":"Computed tomography of cardiac valves: review","volume":"57","author":"Litmanovich","year":"2019","journal-title":"Radiol Clin North Am"},{"key":"2022092120261114300_cvab310-B100","doi-asserted-by":"crossref","first-page":"20180201","DOI":"10.1259\/bjr.20180201","article-title":"Computed tomography in paediatric heart disease","volume":"91","author":"Mortensen","year":"2018","journal-title":"Br J Radiol"},{"key":"2022092120261114300_cvab310-B101","first-page":"265","article-title":"Emerging clinical applications of computed tomography","volume":"8","author":"Liguori","year":"2015","journal-title":"Med Devices (Auckl)"},{"key":"2022092120261114300_cvab310-B102","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0167-7799(02)02004-8","article-title":"Micro-CT in small animal and specimen imaging","volume":"20","author":"Holdsworth","year":"2002","journal-title":"Trends Biotechnol"},{"key":"2022092120261114300_cvab310-B103","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejmp.2014.05.011","article-title":"Micro-CT of rodents: state-of-the-art and future perspectives","volume":"30","author":"Clark","year":"2014","journal-title":"Phys Med"},{"key":"2022092120261114300_cvab310-B104","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000442387","article-title":"The role of micro-CT in 3D histology imaging","volume":"83","author":"Senter-Zapata","year":"2016","journal-title":"Pathobiology"},{"key":"2022092120261114300_cvab310-B105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ehjci\/jet265","article-title":"Normal reference ranges for echocardiography: do we really need more?","volume":"15","author":"Lancellotti","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B106","first-page":"1031","article-title":"Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study","volume":"16","author":"Caballero","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B107","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ehjci\/jev217","article-title":"Cardiac morphology and function reference values derived from a large subset of healthy young Caucasian adults by magnetic resonance imaging","volume":"17","author":"Le Ven","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B108","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fcvm.2019.00173","article-title":"Single-cell RNA sequencing of the cardiovascular system: new looks for old diseases","volume":"6","author":"Chaudhry","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"2022092120261114300_cvab310-B109","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1038\/srep16625","article-title":"X-ray phase-contrast tomography for high-spatial-resolution zebrafish muscle imaging","volume":"5","author":"Vagberg","year":"2015","journal-title":"Sci Rep"},{"key":"2022092120261114300_cvab310-B110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1089\/zeb.2016.1245","article-title":"Contrast-enhanced X-ray micro-computed tomography as a versatile method for anatomical studies of adult zebrafish","volume":"13","author":"Babaei","year":"2016","journal-title":"Zebrafish"},{"key":"2022092120261114300_cvab310-B111","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2017.05.001","article-title":"Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis","volume":"101","author":"Charles","year":"2017","journal-title":"Bone"},{"key":"2022092120261114300_cvab310-B112","doi-asserted-by":"crossref","first-page":"e0177731","DOI":"10.1371\/journal.pone.0177731","article-title":"Zebrafish skeleton development: high resolution micro-CT and FIB-SEM block surface serial imaging for phenotype identification","volume":"12","author":"Silvent","year":"2017","journal-title":"PLoS One"},{"key":"2022092120261114300_cvab310-B113","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cels.2020.02.007","article-title":"Phenomics-based quantification of CRISPR-induced mosaicism in zebrafish","volume":"10","author":"Watson","year":"2020","journal-title":"Cell Syst"},{"key":"2022092120261114300_cvab310-B114","first-page":"280","article-title":"Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association. European Heart.","volume":"16","author":"Cardim","year":"2015","journal-title":"J Cardiovascular Imaging"},{"key":"2022092120261114300_cvab310-B115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ehjci\/jeu323","article-title":"The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging","volume":"16","author":"Galderisi","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2022092120261114300_cvab310-B116","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s11548-011-0657-2","article-title":"Comprehensive visualization of multimodal cardiac imaging data for assessment of coronary artery disease: first clinical results of the SMARTVis tool","volume":"7","author":"Kiri\u015fli","year":"2012","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"2022092120261114300_cvab310-B117","doi-asserted-by":"crossref","DOI":"10.1111\/ahe.12535","article-title":"Corrosion casting of the cardiovascular structure in adult zebrafish for analysis by scanning electron microscopy and X-ray microtomography","author":"De Spiegelaere","year":"2020","journal-title":"Anat Histol Embryol"},{"key":"2022092120261114300_cvab310-B118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0286-3","article-title":"Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm","volume":"51","author":"Jana","year":"2019","journal-title":"Exp Mol Med"},{"key":"2022092120261114300_cvab310-B119","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/ejcts\/ezv197","article-title":"Aortic wall thickness in patients with ascending aortic aneurysm versus acute aortic dissection","volume":"49","author":"Van Puyvelde","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022092120261114300_cvab310-B120","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/ERP-19-0049","article-title":"A review of thoracic aortic aneurysm disease","volume":"7","author":"Clift","year":"2020","journal-title":"Echo Res Pract"},{"key":"2022092120261114300_cvab310-B121","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.matbio.2019.08.005","article-title":"Rise and fall of elastic fibers from development to aging. Consequences on arterial structure-function and therapeutical perspectives","volume":"84","author":"Fhayli","year":"2019","journal-title":"Matrix Biol"},{"key":"2022092120261114300_cvab310-B122","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/CIRCULATIONAHA.108.795401","article-title":"Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications","volume":"119","author":"Tadros","year":"2009","journal-title":"Circulation"},{"key":"2022092120261114300_cvab310-B123","doi-asserted-by":"crossref","first-page":"800","DOI":"10.7326\/0003-4819-106-6-800","article-title":"Aortic root dilatation as a cause of isolated, severe aortic regurgitation. Prevalence, clinical and echocardiographic patterns, and relation to left ventricular hypertrophy and function","volume":"106","author":"Roman","year":"1987","journal-title":"Ann Intern Med"},{"key":"2022092120261114300_cvab310-B124","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/hrt.2005.074781","article-title":"Dilation of the thoracic aorta: medical and surgical management","volume":"92","author":"Nataf","year":"2006","journal-title":"Heart"},{"key":"2022092120261114300_cvab310-B125","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/ejechocard\/jeq056","article-title":"Echocardiography in aortic diseases: EAE recommendations for clinical practice","volume":"11","author":"Evangelista","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"2022092120261114300_cvab310-B126","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/ejcts\/ezv459","article-title":"Blood flow analysis of the aortic arch using computational fluid dynamics","volume":"49","author":"Numata","year":"2016","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvab310\/40509615\/cvab310.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/12\/2665\/45955300\/cvab310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/118\/12\/2665\/45955300\/cvab310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T02:47:57Z","timestamp":1725850077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/12\/2665\/6381565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":126,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,10,5]]},"published-print":{"date-parts":[[2022,9,20]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvab310","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2021,10,5]]}}}