{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:05:55Z","timestamp":1773446755894,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"DOI":"10.1093\/cvr\/cvv015","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T06:08:03Z","timestamp":1422079683000},"page":"279-291","source":"Crossref","is-referenced-by-count":113,"title":["Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis"],"prefix":"10.1093","volume":"105","author":[{"given":"Xingbo","family":"Xu","sequence":"first","affiliation":[]},{"given":"Xiaoying","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Bj\u00f6rn","family":"Tampe","sequence":"additional","affiliation":[]},{"given":"Gunsmaa","family":"Nyamsuren","sequence":"additional","affiliation":[]},{"given":"Xiaopeng","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Lars S.","family":"Maier","sequence":"additional","affiliation":[]},{"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Zeisberg","sequence":"additional","affiliation":[]},{"given":"Gerd","family":"Hasenfuss","sequence":"additional","affiliation":[]},{"given":"Elisabeth M.","family":"Zeisberg","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"key\n\t\t\t\t20170518140004_CVV015C1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2567.2006.02336.x","article-title":"Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan","year":"2006","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170518140004_CVV015C2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00944780","article-title":"Progression of heart failure: a role for interstitial fibrosis","volume":"147","author":"Sabbah","year":"1995","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170518140004_CVV015C3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","article-title":"Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders","volume":"179","author":"Piera-Velazquez","year":"2011","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.77.1.1","article-title":"Molecular regulation of atrioventricular valvuloseptal morphogenesis","volume":"77","author":"Eisenberg","year":"1995","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1165\/rcmb.2009-0031OC","article-title":"Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis","volume":"43","author":"Hashimoto","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature12207","article-title":"EndMT contributes to the onset and progression of cerebral cavernous malformations","volume":"498","author":"Maddaluno","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518140004_CVV015C7","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1016\/j.ajpath.2011.07.042","article-title":"Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis","volume":"179","author":"Rieder","year":"2011","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C8","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1158\/0008-5472.CAN-07-3127","article-title":"Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts","volume":"67","author":"Zeisberg","year":"2007","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C9","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1681\/ASN.2008050513","article-title":"Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition","volume":"19","author":"Zeisberg","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C10","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170518140004_CVV015C11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","article-title":"Cancer epigenetics: from mechanism to therapy","volume":"150","author":"Dawson","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518140004_CVV015C12","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1101\/gad.1232504","article-title":"Epigenetics and cancer","volume":"18","author":"Lund","year":"2004","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170518140004_CVV015C13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/BOR.0b013e32835b13e1","article-title":"Epigenetic regulation of wound healing and fibrosis","volume":"25","author":"Mann","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C14","doi-asserted-by":"crossref","first-page":"iv72","DOI":"10.1093\/ndt\/gft025","article-title":"Contribution of genetics and epigenetics to progression of kidney fibrosis","volume":"29","author":"Tampe","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"key\n\t\t\t\t20170518140004_CVV015C15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.trsl.2014.03.011","article-title":"Epigenetics of idiopathic pulmonary fibrosis","volume":"165","author":"Yang","year":"2015","journal-title":"Transl Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C16","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.scr.2013.07.006","article-title":"Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells","volume":"11","author":"Tan","year":"2013","journal-title":"Stem Cell Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1681\/ASN.2013070723","article-title":"Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis","volume":"25","author":"Tampe","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4161\/epi.1.3.3327","article-title":"Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector","volume":"1","author":"Klug","year":"2006","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20170518140004_CVV015C19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nm.2135","article-title":"Methylation determines fibroblast activation and fibrogenesis in the kidney","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170518140004_CVV015C20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.cell.2011.08.042","article-title":"DNA demethylation dynamics","volume":"146","author":"Bhutani","year":"2011","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518140004_CVV015C21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2013.12.019","article-title":"Reversing DNA methylation: mechanisms, genomics, and biological functions","volume":"156","author":"Wu","year":"2014","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170518140004_CVV015C22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/path.4120","article-title":"The role of promoter hypermethylation in fibroblast activation and fibrogenesis","volume":"229","author":"Zeisberg","year":"2013","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170518140004_CVV015C23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tox.2011.10.011","article-title":"MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats","volume":"290","author":"Tao","year":"2011","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170518140004_CVV015C24","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.7314\/APJCP.2013.14.11.6261","article-title":"Hypermethylation and clinicopathological significance of RASAL1 gene in gastric cancer","volume":"14","author":"Chen","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"key\n\t\t\t\t20170518140004_CVV015C25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3892\/or.2012.1920","article-title":"Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells","volume":"28","author":"Qiao","year":"2012","journal-title":"Oncol Rep"},{"key":"key\n\t\t\t\t20170518140004_CVV015C26","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1093\/nar\/gkr572","article-title":"ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif","volume":"39","author":"Morikawa","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C27","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1172\/JCI70230","article-title":"Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting","volume":"123","author":"Westenskow","year":"2013","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518140004_CVV015C28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000141146.95728.da","article-title":"Heart valve development: endothelial cell signaling and differentiation","volume":"95","author":"Armstrong","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518140004_CVV015C29","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1242\/dev.125.22.4359","article-title":"Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart","volume":"125","author":"Lakkis","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170518140004_CVV015C30","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bbrc.2014.03.014","article-title":"Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-beta-induced phosphorylation of ERK","volume":"446","author":"Wylie-Sears","year":"2014","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/105\/3\/279\/17195623\/cvv015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T14:51:39Z","timestamp":1651071099000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvv015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,23]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,1,23]]},"published-print":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvv015","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,23]]}}}