{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:44:29Z","timestamp":1771379069580,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Portuguese Foundation for Science and Technology"},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["UID\/IC\/00051\/2013"],"award-info":[{"award-number":["UID\/IC\/00051\/2013"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["COMPETE_2020"],"award-info":[{"award-number":["COMPETE_2020"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"POCI","award":["FCOMP-01-0124-FEDER-028695"],"award-info":[{"award-number":["FCOMP-01-0124-FEDER-028695"]}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NETDIAMOND","award":["POCI-01-0145-FEDER-016385"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016385"]}]},{"name":"DOCnet","award":["NORTE-01-0145-FEDER-000003"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000003"]}]},{"name":"DOCnet","award":["NORTE_2020"],"award-info":[{"award-number":["NORTE_2020"]}]},{"name":"DOCnet","award":["PORTUGAL_2020"],"award-info":[{"award-number":["PORTUGAL_2020"]}]},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["SFRH\/BD\/87714\/2012"],"award-info":[{"award-number":["SFRH\/BD\/87714\/2012"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["SFRH\/BD\/96403\/2013"],"award-info":[{"award-number":["SFRH\/BD\/96403\/2013"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulmonary arterial hypertension (PAH) is a devastating disease and treatment options are limited. Urocortin-2 (Ucn-2) has shown promising therapeutic effects in experimental and clinical left ventricular heart failure (HF). Our aim was to analyse the expression of Ucn-2 in human and experimental PAH, and to investigate the effects of human Ucn-2 (hUcn-2) administration in rats with monocrotaline (MCT)-induced pulmonary hypertension (PH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Tissue samples were collected from patients with and without PAH and from rats with MCT-induced PH. hUcn-2 (5 \u03bcg\/kg, bi-daily, i.p., for 10 days) or vehicle was administered to male wistar rats subjected to MCT injection or to pulmonary artery banding (PAB) to induce right ventricular (RV) overload without PAH. Expression of Ucn-2 and its receptor was increased in the RV of patients and rats with PAH. hUcn-2 treatment reduced PAH in MCT rats, resulting in decreased morbidity, improved exercise capacity and attenuated pulmonary arterial and RV remodelling and dysfunction. Additionally, RV gene expression of hypertrophy and failure signalling pathways were attenuated. hUcn-2 treatment also attenuated PAB-induced RV hypertrophy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ucn-2 levels are altered in human and experimental PAH. hUcn-2 treatment attenuates PAH and RV dysfunction in MCT-induced PH, has direct anti-remodelling effects on the pressure-overloaded RV, and improves pulmonary vascular function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvy076","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T20:10:06Z","timestamp":1521749406000},"page":"1165-1177","source":"Crossref","is-referenced-by-count":24,"title":["Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension"],"prefix":"10.1093","volume":"114","author":[{"given":"Rui","family":"Ad\u00e3o","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Pedro","family":"Mendes-Ferreira","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Diana","family":"Santos-Ribeiro","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Carolina","family":"Maia-Rocha","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Lu\u00eds D","family":"Pimentel","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Cl\u00e1udia","family":"Monteiro-Pinto","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Eamon P","family":"Mulvaney","sequence":"first","affiliation":[{"name":"UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin,Ireland"}]},{"given":"Helen M","family":"Reid","sequence":"first","affiliation":[{"name":"UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin,Ireland"}]},{"given":"B Therese","family":"Kinsella","sequence":"first","affiliation":[{"name":"UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin,Ireland"}]},{"given":"Fran\u00e7ois","family":"Potus","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Laval University, Quebec City, Canada"}]},{"given":"Sandra","family":"Breuils-Bonnet","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Laval University, Quebec City, Canada"}]},{"given":"Miriam T","family":"Rademaker","sequence":"first","affiliation":[{"name":"Department of Medicine, Christchurch Heart Institute, University of Otago-Christchurch, Christchurch, New Zealand"}]},{"given":"Steeve","family":"Provencher","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Laval University, Quebec City, Canada"}]},{"given":"S\u00e9bastien","family":"Bonnet","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Laval University, Quebec City, Canada"}]},{"given":"Adelino F","family":"Leite-Moreira","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Carmen","family":"Br\u00e1s-Silva","sequence":"first","affiliation":[{"name":"Department of Surgery and Physiology, Cardiovascular Research and Development Center - UnIC, Faculty of Medicine, University of Porto, Al. Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Faculty of Nutrition and Food Sciences, University of Porto, 4200-319 Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"2020030521245876200_cvy076-B1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Galie","year":"2016","journal-title":"Eur Heart J"},{"key":"2020030521245876200_cvy076-B2","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1172\/JCI60658","article-title":"Molecular pathogenesis 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