{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:32:32Z","timestamp":1772659952545,"version":"3.50.1"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["CVON2014-40"],"award-info":[{"award-number":["CVON2014-40"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union Commission\u2019s Seventh Framework programme","award":["N\u00b0 305507 (HOMAGE)"],"award-info":[{"award-number":["N\u00b0 305507 (HOMAGE)"]}]},{"name":"European Union Commission\u2019s Seventh Framework programme","award":["N\u00b0 602904 (FIBROTARGETS)"],"award-info":[{"award-number":["N\u00b0 602904 (FIBROTARGETS)"]}]},{"name":"European Union Commission\u2019s Seventh Framework programme","award":["FP7-Health-2013-Innovations-1"],"award-info":[{"award-number":["FP7-Health-2013-Innovations-1"]}]},{"name":"European Union Commission\u2019s Seventh Framework programme","award":["N\u00b0 602156 (HECATOS)"],"award-info":[{"award-number":["N\u00b0 602156 (HECATOS)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1093\/cvr\/cvy147","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T15:10:56Z","timestamp":1528902656000},"page":"1273-1280","source":"Crossref","is-referenced-by-count":90,"title":["Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology"],"prefix":"10.1093","volume":"114","author":[{"given":"Jolanda","family":"van der Velden","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands"},{"name":"Netherlands Heart Institute, Utrecht, The Netherlands"}]},{"given":"Carlo G","family":"Tocchetti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, Naples, NA, Italy"}]},{"given":"Gilda","family":"Varricchi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, Naples, NA, Italy"}]},{"given":"Anna","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Federico II University, Naples, NA, Italy"},{"name":"Department of Cardiology, Maastricht University Medical Center & CARIM, Maastricht University, Maastricht, The Netherlands"}]},{"given":"Vasco","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Physiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands"}]},{"given":"Denise","family":"Hilfiker-Kleiner","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Department of Cardiology and Angiology, Medical School Hannover, Germany"}]},{"given":"Nazha","family":"Hamdani","sequence":"additional","affiliation":[{"name":"Department of Systems Physiology, Ruhr University Bochum, Bochum, Germany"}]},{"given":"Adelino F","family":"Leite-Moreira","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, Cardiovascular Research Centre, University of Porto, Porto, Portugal"}]},{"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[{"name":"The James Black Centre & King's British Heart Foundation Centre, King's College, University of London, London, UK"}]},{"given":"Ines","family":"Falc\u00e3o-Pires","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculty of Medicine, Cardiovascular Research Centre, University of Porto, Porto, Portugal"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"},{"name":"REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany"}]},{"given":"Dana K","family":"Dawson","sequence":"additional","affiliation":[{"name":"School of Medicine & Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK"}]},{"given":"Jean-Luc","family":"Balligand","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics, Institut de Recherche Experimentale et Clinique (IREC), and Clinique Universitaire Saint-Luc, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}]},{"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[{"name":"Netherlands Heart Institute, Utrecht, The Netherlands"},{"name":"Department of Cardiology, Maastricht University Medical Center & CARIM, Maastricht University, Maastricht, The Netherlands"},{"name":"Department of Cardiovascular Sciences, Leuven University, Leuven, Belgium"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"key\n\t\t\t\t20180720091906_cvy147-B1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/cvr\/cvx022","article-title":"Metabolic cardiomyopathies\u2014fighting the next epidemic","volume":"113","author":"Maack","year":"2017","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","article-title":"New perspectives on the prevalence of hypertrophic cardiomyopathy","volume":"65","author":"Semsarian","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0735-1097(03)00941-0","article-title":"American College of Cardiology\/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines","volume":"42","author":"Maron","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B4","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1056\/NEJM198911163212005","article-title":"Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1","volume":"321","author":"Jarcho","year":"1989","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B5","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90274-I","article-title":"A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation","volume":"62","author":"Geisterfer-Lowrance","year":"1990","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/cvr\/cvv025","article-title":"Genetic advances in sarcomeric cardiomyopathies: state of the art","volume":"105","author":"Ho","year":"2015","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/01.RES.82.1.106","article-title":"A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity","volume":"82","author":"Bottinelli","year":"1998","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B8","doi-asserted-by":"crossref","first-page":"C200","DOI":"10.1152\/ajpcell.1998.275.1.C200","article-title":"Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy","volume":"275","author":"Morimoto","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B9","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1006\/jmcc.2001.1473","article-title":"Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy","volume":"33","author":"Takahashi-Yanaga","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1073\/pnas.022628899","article-title":"Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy","volume":"99","author":"Morimoto","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B11","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCRESAHA.107.156380","article-title":"Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments","volume":"101","author":"Robinson","year":"2007","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/CIRCHEARTFAILURE.111.963702","article-title":"Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function","volume":"5","author":"van Dijk","year":"2012","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B13","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1074\/jbc.M006746200","article-title":"Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation","volume":"276","author":"Miller","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1161\/CIRCRESAHA.111.300436","article-title":"Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations","volume":"112","author":"Sequeira","year":"2013","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B15","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1113\/jphysiol.2014.274571","article-title":"Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation","volume":"592","author":"Witjas-Paalberends","year":"2014","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B16","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1172\/JCI1940","article-title":"Diastolic dysfunction and altered energetics in the alphaMHC403\/+ mouse model of familial hypertrophic cardiomyopathy","volume":"101","author":"Spindler","year":"1998","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B17","doi-asserted-by":"crossref","first-page":"H2112","DOI":"10.1152\/ajpheart.00571.2005","article-title":"Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation","volume":"289","author":"Chandra","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/cvr\/cvu127","article-title":"Gene-specific increase in energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations","volume":"103","author":"Witjas-Paalberends","year":"2014","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B19","doi-asserted-by":"crossref","first-page":"e005407.","DOI":"10.1161\/JAHA.116.005407","article-title":"Pathogenesis of hypertrophic cardiomyopathy is mutation rather than disease specific: a comparison of the cardiac troponin T E163R and R92Q mouse models","volume":"6","author":"Ferrantini","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B20","doi-asserted-by":"crossref","first-page":"e0180064.","DOI":"10.1371\/journal.pone.0180064","article-title":"MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy","volume":"12","author":"McNamara","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B21","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/eurjhf\/hfr135","article-title":"Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction","volume":"13","author":"Timmer","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B22","doi-asserted-by":"crossref","first-page":"e005604.","DOI":"10.1161\/CIRCIMAGING.116.005604","article-title":"Disease stage-dependent changes in cardiac contractile performance and oxygen utilization underlie reduced myocardial efficiency in human inherited hypertrophic cardiomyopathy","volume":"10","author":"G\u00fc\u00e7l\u00fc","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-9525(03)00081-7","article-title":"Hypertrophic cardiomyopathy: a paradigm for myocardial energy depletion","volume":"19","author":"Ashrafian","year":"2003","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.112.134932","article-title":"Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy","volume":"127","author":"Coppini","year":"2013","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B25","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/S0735-1097(02)03009-7","article-title":"Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy","volume":"41","author":"Crilley","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B26","first-page":"H1030","article-title":"Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts","volume":"269","author":"Hamman","year":"1995","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/01.CIR.96.4.1313","article-title":"Failure to maintain a low ADP concentration impairs diastolic function in hypertrophied rat hearts","volume":"96","author":"Tian","year":"1997","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B28","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1161\/hc3901.095933","article-title":"Chronic phosphocreatine depletion by the creatine analogue \u03b2-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction","volume":"104","author":"Horn","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B29","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1529\/biophysj.107.107557","article-title":"R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts","volume":"93","author":"He","year":"2007","journal-title":"Biophys J"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI119220","article-title":"Role of MgADP in the development of diastolic dysfunction in the intact beating rat heart","volume":"99","author":"Tian","year":"1997","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B31","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1113\/JP270354","article-title":"Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness","volume":"593","author":"Sequeira","year":"2015","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B32","doi-asserted-by":"crossref","first-page":"E7003","DOI":"10.1073\/pnas.1513843112","article-title":"ADP-stimulated contraction: a predictor of thin-filament activation in cardiac disease","volume":"112","author":"Sequeira","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B33","article-title":"Hypertrophic cardiomyopathy: a vicious cycle triggered by sarcomere mutations and secondary disease hits","author":"Wijnker","year":"2018","journal-title":"Antiox Redox Signal"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B34","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1006\/jmcc.2002.2082","article-title":"Cardiac energy metabolism homeostasis: role of cytosolic calcium","volume":"34","author":"Balaban","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.RES.0000232546.92777.05","article-title":"Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes","volume":"99","author":"Maack","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B36","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2015.07.008","article-title":"Reversal of mitochondrial transhydrogenase causes oxidative stress in heart failure","volume":"22","author":"Nickel","year":"2015","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jacc.2011.05.018","article-title":"Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations","volume":"58","author":"Olivotto","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.yjmcc.2011.08.028","article-title":"The coronary circulation and blood flow in left ventricular hypertrophy","volume":"52","author":"Camici","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B39","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1161\/CIRCULATIONAHA.106.657023","article-title":"Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging","volume":"115","author":"Petersen","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/cvr\/cvv024","article-title":"Defining phenotypes and disease progression in sarcomeric cardiomyopathies: contemporary role of clinical investigations","volume":"105","author":"Olivotto","year":"2015","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B41","doi-asserted-by":"crossref","first-page":"49.","DOI":"10.1186\/s12968-014-0049-1","article-title":"Coronary microvascular ischemia in hypertrophic cardiomyopathy\u2014a pixel-wise quantitative cardiovascular magnetic resonance perfusion study","volume":"16","author":"Ismail","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B42","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jacc.2016.07.751","article-title":"Mechanisms of myocardial ischemia in hypertrophic cardiomyopathy: insights from wave intensity analysis and magnetic resonance","volume":"68","author":"Raphael","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B43","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/eci.12544","article-title":"Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype","volume":"45","author":"G\u00fc\u00e7l\u00fc","year":"2015","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B44","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jacc.2010.05.010","article-title":"Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"56","author":"O'Hanlon","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcmg.2012.09.012","article-title":"Prognostic role of CMR in patients presenting with ventricular arrhythmias","volume":"6","author":"Dawson","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B46","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/ejhf.678","article-title":"Metabolic support for the heart: complementary therapy for heart failure?","volume":"18","author":"Heggermont","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B47","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1152\/ajpendo.00093.2009","article-title":"The Randle cycle revisited: a new head for an old hat","volume":"297","author":"Hue","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B48","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cvr\/cvr038","article-title":"Modulating fatty acid oxidation in heart failure","volume":"90","author":"Lionetti","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B49","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1096\/fj.04-2263com","article-title":"Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart","volume":"18","author":"Sharma","year":"2004","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B50","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/CIRCULATIONAHA.116.024171","article-title":"Inhibition of microRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-Induced cardiac hypertrophy and dysfunction","volume":"136","author":"Heggermont","year":"2017","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B51","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/heartjnl-2013-304908","article-title":"Exercise capacity and paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"100","author":"Azarbal","year":"2014","journal-title":"Heart"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B52","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jchf.2014.11.011","article-title":"Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: a potential role for comprehensive noninvasive hemodynamic assessment","volume":"3","author":"Finocchiaro","year":"2015","journal-title":"JACC Heart Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B53","doi-asserted-by":"crossref","first-page":"11303.","DOI":"10.1038\/ncomms11303","article-title":"A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation","volume":"7","author":"Orr","year":"2016","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B54","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.amjcard.2015.12.058","article-title":"Impact of genotype on the occurrence of atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"117","author":"Bongini","year":"2016","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B55","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvt119","article-title":"Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy","volume":"99","author":"Witjas-Paalberends","year":"2013","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B56","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B57","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1172\/JCI42028","article-title":"Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires tgf-\u03b2","volume":"120","author":"Teekakirikul","year":"2010","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B58","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.201207033","article-title":"Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics","volume":"199","author":"Teekakirikul","year":"2012","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1016138813353","article-title":"Stretch-induced paracrine hypertrophic stimuli increase TGF-\u03b21 expression in cardiomyocytes","volume":"236","author":"van Wamel","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1007046105745","article-title":"Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts","volume":"208","author":"Ruwhof","year":"2000","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B61","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B62","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cardfail.2016.08.001","article-title":"Metabolic modulation by medium-chain triglycerides reduces oxidative stress and ameliorates CD36-mediated cardiac remodeling in spontaneously hypertensive rat in the initial and established stages of hypertrophy","volume":"23","author":"Saifudeen","year":"2017","journal-title":"J Cardiac Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B63","first-page":"H1425","article-title":"Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts on adrenergic stress: benefits of a medium-chain fatty acid","volume":"288","author":"Labarthe","year":"2005","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B64","first-page":"349","article-title":"Low STAT3 expression sensitizes to toxic effects of \u03b2-adrenergic receptor stimulation in peripartum cardiomyopathy","volume":"38","author":"Stapel","year":"2017","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B65","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/cvr\/cvw051","article-title":"Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression","volume":"110","author":"Byrne","year":"2016","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/01.CIR.0000026392.80723.DC","article-title":"Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure","volume":"106","author":"Razeghi","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B67","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/ehjci\/jev009","article-title":"Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study","volume":"16","author":"G\u00fc\u00e7l\u00fc","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B68","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1039\/C4MB00594E","article-title":"Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy","volume":"11","author":"Gehmlich","year":"2015","journal-title":"Mol Biosyst"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B69","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.109.934059","article-title":"Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy","volume":"122","author":"Abozguia","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B70","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/13543776.2016.1211111","article-title":"Pleiotropic mechanisms of action of perhexiline in heart failure","volume":"26","author":"George","year":"2016","journal-title":"Expert Opin Ther Pat"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B71","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2012.12.014","article-title":"Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome","volume":"55","author":"Yin","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B72","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.cjca.2017.03.009","article-title":"Complex energy metabolic changes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction","volume":"33","author":"de Jong","year":"2017","journal-title":"Can J Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B73","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00726-016-2236-x","article-title":"Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms","volume":"48","author":"Zervou","year":"2016","journal-title":"Amino Acids"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B74","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.CIR.103.12.1649","article-title":"Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium","volume":"103","author":"Moniotte","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B75","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.CIR.0000139331.85766.AF","article-title":"Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization","volume":"110","author":"Dessy","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B76","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.90.8.3665","article-title":"Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3\/beta 2-adrenergic receptor","volume":"90","author":"Liggett","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B77","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI2191","article-title":"The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle","volume":"102","author":"Gauthier","year":"1998","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B78","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/CIRCULATIONAHA.113.004940","article-title":"Enhanced expression of \u03b23-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase","volume":"129","author":"Belge","year":"2014","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B79","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1006\/jmcc.2000.1216","article-title":"Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors","volume":"32","author":"Musialek","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B80","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00395-010-0084-5","article-title":"PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation","volume":"105","author":"Lee","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B81","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCRESAHA.108.184408","article-title":"Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs","volume":"104","author":"Kr\u00fcger","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B82","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCRESAHA.107.164798","article-title":"Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice","volume":"102","author":"Zhang","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B83","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/eurheartj\/ehx366","article-title":"Cardiac myocyte \u03b23-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling","volume":"39","author":"Hermida","year":"2018","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B84","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1161\/CIRCULATIONAHA.110.964619","article-title":"\u03b2(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification","volume":"122","author":"Bundgaard","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B85","doi-asserted-by":"crossref","first-page":"43951.","DOI":"10.1038\/srep43951","article-title":"MRI assessment of cardiomyopathy induced by \u03b21-adrenoreceptor autoantibodies and protection through \u03b23-adrenoreceptor overexpression","volume":"7","author":"Vanhoutte","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B86","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCULATIONAHA.104.532960","article-title":"Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol","volume":"112","author":"Dessy","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B87","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","article-title":"Activation of human brown adipose tissue by a \u03b23-adrenergic receptor agonist","volume":"21","author":"Cypess","year":"2015","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B88","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1200113","article-title":"Cardiac myosin activation: a potential therapeutic approach for systolic heart failure","volume":"331","author":"Malik","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B89","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/CIRCHEARTFAILURE.114.002152","article-title":"Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity","volume":"8","author":"Bakkehaug","year":"2015","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/JP275050","article-title":"Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament","volume":"596","author":"Kampourakis","year":"2018","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B91","doi-asserted-by":"crossref","first-page":"16571","DOI":"10.1074\/jbc.M117.776815","article-title":"A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle","volume":"292","author":"Kawas","year":"2017","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B92","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.aad3456","article-title":"A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice","volume":"351","author":"Green","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B93","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1172\/JCI64365","article-title":"MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy","volume":"123","author":"Halkein","year":"2013","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B94","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/CIRCRESAHA.114.303915","article-title":"Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure","volume":"114","author":"Kumarswamy","year":"2014","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180720091906_cvy147-B95","doi-asserted-by":"crossref","first-page":"94493","DOI":"10.1172\/jci.insight.94493","article-title":"Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models","volume":"3","author":"Vakrou","year":"2018","journal-title":"JCI Insight"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/114\/10\/1273\/25195459\/cvy147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T07:46:52Z","timestamp":1571471212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/114\/10\/1273\/5038409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":95,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,6,15]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvy147","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8,1]]},"published":{"date-parts":[[2018,6,15]]}}}